| PARUCH, Kamil, Benoit Jean-Pierre CARBAIN, Štěpán HAVEL, Vít VŠIANSKÝ, Fedor NIKULENKOV and Lumír KREJČÍ. ヌクレアーゼの阻害剤としての置換プロパンアミド (Substituted propanamides as inhibitors of nucleases). 2022. |
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| Basic information | |
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| Original name | ヌクレアーゼの阻害剤としての置換プロパンアミド |
| Name (in English) | Substituted propanamides as inhibitors of nucleases |
| Authors | PARUCH, Kamil (203 Czech Republic, guarantor, belonging to the institution), Benoit Jean-Pierre CARBAIN (250 France, belonging to the institution), Štěpán HAVEL (203 Czech Republic, belonging to the institution), Vít VŠIANSKÝ (203 Czech Republic, belonging to the institution), Fedor NIKULENKOV (203 Czech Republic, belonging to the institution) and Lumír KREJČÍ (203 Czech Republic, belonging to the institution). |
| Edition | Number: JP7148999, Publisher: Japan Patent office, Place of publication: Kasumigaseki, Chiyoda-ku Tokyo, Owner's name: Masarykova univerzita, 2022. |
| Other information | |
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| Original language | Japanese |
| Type of outcome | Patent |
| Field of Study | 10401 Organic chemistry |
| Country of publisher | Japan |
| Confidentiality degree | is not subject to a state or trade secret |
| WWW | URL |
| RIV identification code | RIV/00216224:14310/22:00127610 |
| Organization unit | Faculty of Science |
| Keywords in English | DNA; propanamide; nuclease |
| Changed by | Changed by: Mgr. Marie Šípková, DiS., učo 437722. Changed: 22/3/2023 11:20. |
| Abstract |
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| 本発明は、構造式（１）によって表される化合物を提供する： 【化１】 式中、 Ｒ１、Ｒ２、Ｒ３、Ｒ４、Ｒ５、Ｒ６は、特許請求の範囲で定義されている通りである。当該化合物は、ヌクレアーゼの阻害剤であり、特に、増殖性疾患、神経変性疾患、および他のゲノム不安定性関連疾患の治療方法および／または予防方法において、有用である。 |
| Abstract (in English) |
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| The invention provides compounds represented by the structural formula (1): wherein R1, R2, R3, R4, R5, R6 are as defined in the claims. The compounds are inhibitors of nucleases, and are useful in particular in a method of treatment and/or prevention of proliferative diseases, neurodegenerative diseases, and other genomic instability associated diseases. |
| Links | |
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| EF16_025/0007381, research and development project | Name: Preklinická progrese nových organických sloučenin s cílenou biologickou aktivitou |
| LM2018130, research and development project | Name: Národní infrastruktura chemické biologie (Acronym: CZ-OPENSCREEN) |
| Investor: Ministry of Education, Youth and Sports of the CR | |
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