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@article{2243765,
author = {Michálek, Ondřej and Walker, Andrew A. and Šedo, Ondrej and Zdráhal, Zbyněk and King, Glenn F. and Pekár, Stanislav},
article_location = {ENGLAND},
article_number = {1},
doi = {http://dx.doi.org/10.1038/s41598-022-24694-5},
keywords = {white-tailed spiders; Prey-specialised spiders; spiders; Lampona},
language = {eng},
issn = {2045-2322},
journal = {SCIENTIFIC REPORTS},
title = {Composition and toxicity of venom produced by araneophagous white-tailed spiders (Lamponidae: Lampona sp.)},
url = {https://doi.org/10.1038/s41598-022-24694-5},
volume = {12},
year = {2022}
}
TY - JOUR
ID - 2243765
AU - Michálek, Ondřej - Walker, Andrew A. - Šedo, Ondrej - Zdráhal, Zbyněk - King, Glenn F. - Pekár, Stanislav
PY - 2022
TI - Composition and toxicity of venom produced by araneophagous white-tailed spiders (Lamponidae: Lampona sp.)
JF - SCIENTIFIC REPORTS
VL - 12
IS - 1
SP - "21597"
EP - "21597"
PB - NATURE PORTFOLIO
SN - 20452322
KW - white-tailed spiders
KW - Prey-specialised spiders
KW - spiders
KW - Lampona
UR - https://doi.org/10.1038/s41598-022-24694-5
N2 - Prey-specialised spiders are adapted to capture specific prey items, including dangerous prey. The venoms of specialists are often prey-specific and less complex than those of generalists, but their venom composition has not been studied in detail. Here, we investigated the venom of the prey-specialised white-tailed spiders (Lamponidae: Lampona), which utilise specialised morphological and behavioural adaptations to capture spider prey. We analysed the venom composition using proteo-transcriptomics and taxon-specific toxicity using venom bioassays. Our analysis identified 208 putative toxin sequences, comprising 103 peptides < 10 kDa and 105 proteins > 10 kDa. Most peptides belonged to one of two families characterised by scaffolds containing eight or ten cysteine residues. Toxin-like proteins showed similarity to galectins, leucine-rich repeat proteins, trypsins and neprilysins. The venom of Lampona was shown to be more potent against the preferred spider prey than against alternative cricket prey. In contrast, the venom of a related generalist was similarly potent against both prey types. These data provide insights into the molecular adaptations of venoms produced by prey-specialised spiders.
ER -
MICHÁLEK, Ondřej, Andrew A. WALKER, Ondrej ŠEDO, Zbyněk ZDRÁHAL, Glenn F. KING and Stanislav PEKÁR. Composition and toxicity of venom produced by araneophagous white-tailed spiders (Lamponidae: Lampona sp.). \textit{SCIENTIFIC REPORTS}. ENGLAND: NATURE PORTFOLIO, 2022, vol.~12, No~1, p.~''21597'', 13 pp. ISSN~2045-2322. Available from: https://dx.doi.org/10.1038/s41598-022-24694-5.
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