Orally Administered Probiotics in the Prevention of
Chemotherapy (± Radiotherapy)-Induced Gastrointestinal
Toxicity: A Systematic Review With Meta-Analysis of Randomized
Trials

J 2022

Orally Administered Probiotics in the Prevention of Chemotherapy (± Radiotherapy)-Induced Gastrointestinal Toxicity: A Systematic Review With Meta-Analysis of Randomized Trials

DANIS, Radoslav, Michal MEGO, Mariya ANTONOVA, Radka ŠTĚPÁNOVÁ, Adam SVOBODNÍK et. al.

Basic information

Original name

Orally Administered Probiotics in the Prevention of Chemotherapy (± Radiotherapy)-Induced Gastrointestinal Toxicity: A Systematic Review With Meta-Analysis of Randomized Trials

Authors

DANIS, Radoslav (guarantor), Michal MEGO, Mariya ANTONOVA, Radka ŠTĚPÁNOVÁ (203 Czech Republic), Adam SVOBODNÍK (203 Czech Republic), Renata HEJNOVÁ (203 Czech Republic, belonging to the institution) and Martin WAWRUCH

Edition

INTEGRATIVE CANCER THERAPIES, THOUSAND OAKS, SAGE PUBLICATIONS INC, 2022, 1534-7354

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30204 Oncology

Country of publisher

United States of America

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 2.900

RIV identification code

RIV/00216224:14110/22:00127762

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.1177/15347354221144309

UT WoS

000905190300003

Keywords (in Czech)

probiotics; cancer; chemotherapy; adverse effects; diarrhea; prevention

Keywords in English

probiotics; cancer; chemotherapy; adverse effects; diarrhea; prevention

Abstract

V originále

Background: Chemoradiotherapy-induced gastrointestinal toxicity may lead to a significant impairment of the oncological patient’s quality of life, as well as to reduced adherence to the treatment, which may have a negative impact on survival and mortality rates. Objective: The aim of this review was to investigate whether oral probiotic administration prevents chemotherapy (± radiotherapy)-induced gastrointestinal toxicity, particularly diarrhea. Methods: We searched the MEDLINE, Web of Science, and SCOPUS databases for randomized controlled trials in English published between 1990 and 2020. We conducted statistical data analyses expressing the treatment effect size as a risk ratio (RR) together with a 95% confidence interval (CI). Implications are based on trials rated as having a low risk of bias (RoB). Results: We included 8 trials (n=697 participants), from which 3 studies rated as low RoB contained primary endpoint data; the risk of developing grade 3/4 diarrhea in patients receiving probiotics was reduced by 78% compared to the control group (RR=0.22 [95% CI 0.05-1.08]; P=.06; n=114 participants). Probiotics showed preventive effects in patients treated with chemotherapy alone (RR=0.34 [0.12-0.94]; P=.04, n=121 participants) and in patients with colorectal cancer (RR=0.56 [0.34-0.92]; P=.02; n=208 participants). The reduction in the incidence of overall diarrhea was not significant. Conclusions: Probiotics failed to prove a preventive effect of statistical significance against the development of severe and overall diarrhea in cancer patients treated with chemotherapy (± radiotherapy). However, we cannot rule out that the effects of probiotics are clinically relevant, especially in certain subgroups of patients. This needs to be clarified in further well-performed studies.

Links

CZ.02.1.01/0.0/0.0/16_013/0001826, interní kód MU
(CEP code: EF16_013/0001826)

Name: CZECRIN_PRO PACIENTY - zavádění inovativních moderních terapií

Investor: Ministry of Education, Youth and Sports of the CR, Priority axis 1: Strengthening capacities for high-quality research

90128, large research infrastructures

Name: CZECRIN III

Citovat

DANIS, Radoslav, Michal MEGO, Mariya ANTONOVA, Radka ŠTĚPÁNOVÁ, Adam SVOBODNÍK, Renata HEJNOVÁ and Martin WAWRUCH. Orally Administered Probiotics in the Prevention of Chemotherapy (± Radiotherapy)-Induced Gastrointestinal Toxicity: A Systematic Review With Meta-Analysis of Randomized Trials. INTEGRATIVE CANCER THERAPIES. THOUSAND OAKS: SAGE PUBLICATIONS INC, 2022, vol. 21, January-December 2022, p. 1-13. ISSN 1534-7354. Available from: https://dx.doi.org/10.1177/15347354221144309.

@article{2244038,
   author = {Danis, Radoslav and Mego, Michal and Antonova, Mariya and Štěpánová, Radka and Svobodník, Adam and Hejnová, Renata and Wawruch, Martin},
   article_location = {THOUSAND OAKS},
   article_number = {January-December 2022},
   doi = {http://dx.doi.org/10.1177/15347354221144309},
   keywords = {probiotics; cancer; chemotherapy; adverse effects; diarrhea; prevention},
   language = {eng},
   issn = {1534-7354},
   journal = {INTEGRATIVE CANCER THERAPIES},
   title = {Orally Administered Probiotics in the Prevention of Chemotherapy (± Radiotherapy)-Induced Gastrointestinal Toxicity: A Systematic Review With Meta-Analysis of Randomized Trials},
   url = {https://journals.sagepub.com/doi/10.1177/15347354221144309},
   volume = {21},
   year = {2022}
}

TY  - JOUR
ID  - 2244038
AU  - Danis, Radoslav - Mego, Michal - Antonova, Mariya - Štěpánová, Radka - Svobodník, Adam - Hejnová, Renata - Wawruch, Martin
PY  - 2022
TI  - Orally Administered Probiotics in the Prevention of Chemotherapy (± Radiotherapy)-Induced Gastrointestinal Toxicity: A Systematic Review With Meta-Analysis of Randomized Trials
JF  - INTEGRATIVE CANCER THERAPIES
VL  - 21
IS  - January-December 2022
SP  - 1-13
EP  - 1-13
PB  - SAGE PUBLICATIONS INC
SN  - 15347354
KW  - probiotics
KW  - cancer
KW  - chemotherapy
KW  - adverse effects
KW  - diarrhea
KW  - prevention
UR  - https://journals.sagepub.com/doi/10.1177/15347354221144309
N2  - Background: Chemoradiotherapy-induced gastrointestinal toxicity may lead to a significant impairment of the oncological patient’s quality of life, as well as to reduced adherence to the treatment, which may have a negative impact on survival and mortality rates. Objective: The aim of this review was to investigate whether oral probiotic administration prevents chemotherapy (± radiotherapy)-induced gastrointestinal toxicity, particularly diarrhea. Methods: We searched the MEDLINE, Web of Science, and SCOPUS databases for randomized controlled trials in English published between 1990 and 2020. We conducted statistical data analyses expressing the treatment effect size as a risk ratio (RR) together with a 95% confidence interval (CI). Implications are based on trials rated as having a low risk of bias (RoB). Results: We included 8 trials (n=697 participants), from which 3 studies rated as low RoB contained primary endpoint data; the risk of developing grade 3/4 diarrhea in patients receiving probiotics was reduced by 78% compared to the control group (RR=0.22 [95% CI 0.05-1.08]; P=.06; n=114 participants). Probiotics showed preventive effects in patients treated with chemotherapy alone (RR=0.34 [0.12-0.94]; P=.04, n=121 participants) and in patients with colorectal cancer (RR=0.56 [0.34-0.92]; P=.02; n=208 participants). The reduction in the incidence of overall diarrhea was not significant. Conclusions: Probiotics failed to prove a preventive effect of statistical significance against the development of severe and overall diarrhea in cancer patients treated with chemotherapy (± radiotherapy). However, we cannot rule out that the effects of probiotics are clinically relevant, especially in certain subgroups of patients. This needs to be clarified in further well-performed studies.
ER  -

DANIS, Radoslav, Michal MEGO, Mariya ANTONOVA, Radka ŠTĚPÁNOVÁ, Adam SVOBODNÍK, Renata HEJNOVÁ and Martin WAWRUCH. Orally Administered Probiotics in the Prevention of Chemotherapy (± Radiotherapy)-Induced Gastrointestinal Toxicity: A Systematic Review With Meta-Analysis of Randomized Trials. \textit{INTEGRATIVE CANCER THERAPIES}. THOUSAND OAKS: SAGE PUBLICATIONS INC, 2022, vol.~21, January-December 2022, p.~1-13. ISSN~1534-7354. Available from: https://dx.doi.org/10.1177/15347354221144309.

Detailed Information on Publication Record