Detailed Information on Publication Record
2022
Prenylated flavonoids combating mycobacteria
ŠKOVRANOVÁ, Gabriela, Marie ČULENOVÁ, Lenka MOLČANOVÁ, Jakub TREML, Fabian ALPERTH et. al.Basic information
Original name
Prenylated flavonoids combating mycobacteria
Authors
ŠKOVRANOVÁ, Gabriela (703 Slovakia, belonging to the institution), Marie ČULENOVÁ (203 Czech Republic, belonging to the institution), Lenka MOLČANOVÁ (703 Slovakia, belonging to the institution), Jakub TREML (203 Czech Republic, belonging to the institution), Fabian ALPERTH (40 Austria), Franz BUCAR (40 Austria) and Alice SYCHROVÁ (203 Czech Republic, belonging to the institution)
Edition
Natural Products in Drug Discovery and Development – Advances and Perspectives: PSE Meeting September 19–22, 2022, Iasi, Romania, 2022
Other information
Language
English
Type of outcome
Prezentace na konferencích
Field of Study
30104 Pharmacology and pharmacy
Confidentiality degree
není předmětem státního či obchodního tajemství
References:
RIV identification code
RIV/00216224:14160/22:00134039
Organization unit
Faculty of Pharmacy
Keywords in English
antimicrobial activity; membrane disruption; mycobacterium; prenylated flavonoids
Změněno: 25/5/2023 15:40, JUDr. Sabina Krejčiříková
V originále
Globally, tuberculosis is one of the primary causes of death. Resistant strains of Mycobacterium tuberculosis as well as other strains of mycobacteria are prompting the search for new drugs and solutions. Twelve prenylated compounds were tested against mycobacterial strains, and the microdilution method revealed a significant antibacterial effect with minimal inhibitory concentrations ranging from 2-16 µg/mL. Membrane damage and permeability disruption is one of the mechanisms of action by which prenylated flavonoids exerted ≤40% effect. The effect of the compounds on the viability of THP-1 cells differentiated into macrophages demonstrated their toxicity with respect to the concentrations used. However, prenylated phenolics represent potential model structures for the development of new antituberculosis drugs.
In Czech
Tuberkulóza celosvetovo patrí medzi primárne príčiny smrti. Rezistentné kmene Mycobacterium tuberculosis ako aj iné kmene mykobaktérií nabádajú k hľadaniu nových liečiv a riešení. Dvanásť prenylovaných zlúčenín bolo testovaných voči mykobakteriálnym kmeňom, pričom mikrodilučná metóda odhalila významný antibakteriálny efekt s minimálnou inhibičnou koncentráciou v rozmedzí 2–16 µg/mL. Poškodenie membrány a narušenie permeability je jedným z mechanizmov účinku, ktorými prenylované flavonoidy účinkovali na ≤40%. Vplyv látok na viabilitu THP-1 buniek diferencovaných v makrofágy preukázal ich toxicitu vzhľadom k použitým koncentráciám. Prenylované fenoly však predstavujú potenciálne modelové štruktúry pre vývoj nových antituberkulotík.
Links
| GF21-38204L, research and development project |
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| MUNI/A/1279/2021, interní kód MU |
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