White matter alterations in MR-negative temporal and frontal
lobe epilepsy using fixel-based analysis

J 2023

White matter alterations in MR-negative temporal and frontal lobe epilepsy using fixel-based analysis

BARTOŇOVÁ, Michaela, Jacques-Donald TOURNIER, Marek BARTOŇ, Pavel ŘÍHA, Lubomír VOJTÍŠEK et. al.

Basic information

Original name

White matter alterations in MR-negative temporal and frontal lobe epilepsy using fixel-based analysis

Authors

BARTOŇOVÁ, Michaela (703 Slovakia, belonging to the institution), Jacques-Donald TOURNIER (826 United Kingdom of Great Britain and Northern Ireland), Marek BARTOŇ (203 Czech Republic, belonging to the institution), Pavel ŘÍHA (203 Czech Republic, belonging to the institution), Lubomír VOJTÍŠEK (203 Czech Republic, belonging to the institution), Radek MAREČEK (203 Czech Republic, belonging to the institution), Irena DOLEŽALOVÁ (203 Czech Republic, belonging to the institution) and Ivan REKTOR (203 Czech Republic, guarantor, belonging to the institution)

Edition

Scientific Reports, Berlin, NATURE PORTFOLIO, 2023, 2045-2322

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30210 Clinical neurology

Country of publisher

Germany

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 4.600 in 2022

RIV identification code

RIV/00216224:14740/23:00130158

Organization unit

Central European Institute of Technology

DOI

http://dx.doi.org/10.1038/s41598-022-27233-4

UT WoS

000907164800057

Keywords in English

Focal Epilepsy; Temporal Lobe Epilepsy (TLE); Frontal Lobe Epilepsy (FLE); MR-negative; Fixel-Based Analysis (FBA); Fibre Density; Fibre Cross-section

Abstract

V originále

This study focuses on white matter alterations in pharmacoresistant epilepsy patients with no visible lesions in the temporal and frontal lobes on clinical MRI (i.e. MR-negative) with lesions confirmed by resective surgery. The aim of the study was to extend the knowledge about group-specific neuropathology in MR-negative epilepsy. We used the fixel-based analysis (FBA) that overcomes the limitations of traditional diffusion tensor image analysis, mainly within-voxel averaging of multiple crossing fibres. Group-wise comparisons of fixel parameters between healthy controls (N = 100) and: (1) frontal lobe epilepsy (FLE) patients (N = 9); (2) temporal lobe epilepsy (TLE) patients (N = 13) were performed. A significant decrease of the cross-section area of the fixels in the superior longitudinal fasciculus was observed in the FLE. Results in TLE reflected widespread atrophy of limbic, thalamic, and cortico-striatal connections and tracts directly connected to the temporal lobe (such as the anterior commissure, inferior fronto-occipital fasciculus, uncinate fasciculus, splenium of corpus callosum, and cingulum bundle). Alterations were also observed in extratemporal connections (brainstem connection, commissural fibres, and parts of the superior longitudinal fasciculus). To our knowledge, this is the first study to use an advanced FBA method not only on the datasets of MR-negative TLE patients, but also MR-negative FLE patients, uncovering new common tract-specific alterations on the group level.

Links

LM2018129, research and development project

Name: Národní infrastruktura pro biologické a medicínské zobrazování Czech-BioImaging

Investor: Ministry of Education, Youth and Sports of the CR

MUNI/IGA/1044/2020, interní kód MU

Name: Localization of a seizure-onset zone in patients with epilepsy: A structural connectome study (Acronym: EPICOME)

Investor: Masaryk University

NU21-04-00254, research and development project

Name: Detekce zóny počátku záchvatu u multi-lezionální epilepsie s užitím multimodálního neurozobrazování (Acronym: MultiEPI)

Investor: Ministry of Health of the CR, Detection of seizure onset zone in multi-lesional epilepsies using multimodal imaging methods, Subprogram 1 - standard

Citovat

BARTOŇOVÁ, Michaela, Jacques-Donald TOURNIER, Marek BARTOŇ, Pavel ŘÍHA, Lubomír VOJTÍŠEK, Radek MAREČEK, Irena DOLEŽALOVÁ and Ivan REKTOR. White matter alterations in MR-negative temporal and frontal lobe epilepsy using fixel-based analysis. Scientific Reports. Berlin: NATURE PORTFOLIO, 2023, vol. 13, No 1, p. 1-10. ISSN 2045-2322. Available from: https://dx.doi.org/10.1038/s41598-022-27233-4.

@article{2244942,
   author = {Bartoňová, Michaela and Tournier, JacquesandDonald and Bartoň, Marek and Říha, Pavel and Vojtíšek, Lubomír and Mareček, Radek and Doležalová, Irena and Rektor, Ivan},
   article_location = {Berlin},
   article_number = {1},
   doi = {http://dx.doi.org/10.1038/s41598-022-27233-4},
   keywords = {Focal Epilepsy; Temporal Lobe Epilepsy (TLE); Frontal Lobe Epilepsy (FLE); MR-negative; Fixel-Based Analysis (FBA); Fibre Density; Fibre Cross-section},
   language = {eng},
   issn = {2045-2322},
   journal = {Scientific Reports},
   title = {White matter alterations in MR-negative temporal and frontal lobe epilepsy using fixel-based analysis},
   url = {https://www.nature.com/articles/s41598-022-27233-4},
   volume = {13},
   year = {2023}
}

TY  - JOUR
ID  - 2244942
AU  - Bartoňová, Michaela - Tournier, Jacques-Donald - Bartoň, Marek - Říha, Pavel - Vojtíšek, Lubomír - Mareček, Radek - Doležalová, Irena - Rektor, Ivan
PY  - 2023
TI  - White matter alterations in MR-negative temporal and frontal lobe epilepsy using fixel-based analysis
JF  - Scientific Reports
VL  - 13
IS  - 1
SP  - 1-10
EP  - 1-10
PB  - NATURE PORTFOLIO
SN  - 20452322
KW  - Focal Epilepsy
KW  - Temporal Lobe Epilepsy (TLE)
KW  - Frontal Lobe Epilepsy (FLE)
KW  - MR-negative
KW  - Fixel-Based Analysis (FBA)
KW  - Fibre Density
KW  - Fibre Cross-section
UR  - https://www.nature.com/articles/s41598-022-27233-4
N2  - This study focuses on white matter alterations in pharmacoresistant epilepsy patients with no visible lesions in the temporal and frontal lobes on clinical MRI (i.e. MR-negative) with lesions confirmed by resective surgery. The aim of the study was to extend the knowledge about group-specific neuropathology in MR-negative epilepsy. We used the fixel-based analysis (FBA) that overcomes the limitations of traditional diffusion tensor image analysis, mainly within-voxel averaging of multiple crossing fibres. Group-wise comparisons of fixel parameters between healthy controls (N = 100) and: (1) frontal lobe epilepsy (FLE) patients (N = 9); (2) temporal lobe epilepsy (TLE) patients (N = 13) were performed. A significant decrease of the cross-section area of the fixels in the superior longitudinal fasciculus was observed in the FLE. Results in TLE reflected widespread atrophy of limbic, thalamic, and cortico-striatal connections and tracts directly connected to the temporal lobe (such as the anterior commissure, inferior fronto-occipital fasciculus, uncinate fasciculus, splenium of corpus callosum, and cingulum bundle). Alterations were also observed in extratemporal connections (brainstem connection, commissural fibres, and parts of the superior longitudinal fasciculus). To our knowledge, this is the first study to use an advanced FBA method not only on the datasets of MR-negative TLE patients, but also MR-negative FLE patients, uncovering new common tract-specific alterations on the group level.
ER  -

BARTOŇOVÁ, Michaela, Jacques-Donald TOURNIER, Marek BARTOŇ, Pavel ŘÍHA, Lubomír VOJTÍŠEK, Radek MAREČEK, Irena DOLEŽALOVÁ and Ivan REKTOR. White matter alterations in MR-negative temporal and frontal lobe epilepsy using fixel-based analysis. \textit{Scientific Reports}. Berlin: NATURE PORTFOLIO, 2023, vol.~13, No~1, p.~1-10. ISSN~2045-2322. Available from: https://dx.doi.org/10.1038/s41598-022-27233-4.

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