Analytical strategies for chemical exposomics: exploring limits and feasibility

VITALE, Chiara Maria, Elliott James PRICE, Gary W MILLER, Arthur DAVID, Jean-Philippe ANTIGNAC, Robert BAROUKI and Jana KLÁNOVÁ. Analytical strategies for chemical exposomics: exploring limits and feasibility. Exposome. Oxford University Press, 2021, vol. 1, No 1, p. 1-18. ISSN 2635-2265. Available from: https://dx.doi.org/10.1093/exposome/osab003.

Basic information

• Original name: Analytical strategies for chemical exposomics: exploring limits and feasibility
• Authors: VITALE, Chiara Maria (380 Italy, belonging to the institution), Elliott James PRICE (826 United Kingdom of Great Britain and Northern Ireland, guarantor, belonging to the institution), Gary W MILLER, Arthur DAVID, Jean-Philippe ANTIGNAC, Robert BAROUKI and Jana KLÁNOVÁ (203 Czech Republic, belonging to the institution).
• Edition: Exposome, Oxford University Press, 2021, 2635-2265.

Other information

• Original language: English
• Type of outcome: Article in a journal
• Field of Study: 10511 Environmental sciences
• Country of publisher: United Kingdom of Great Britain and Northern Ireland
• Confidentiality degree: is not subject to a state or trade secret
• WWW: URL
• RIV identification code: RIV/00216224:14310/21:00127852
• Organization unit: Faculty of Science
• Doi: http://dx.doi.org/10.1093/exposome/osab003
• Keywords in English: trace analysis of environmental contaminants; suspect screening and non-target analysis; exposome and metabolome; SPE and passive sampling/SPME; LC-HRMS and GC-HRMS; chemicals of emerging concern
• Tags: rivok
• Tags: International impact, Reviewed

Abstract

Tackling the challenges of chemical exposomics will require the implementation of diverse analytical strategies and technological advancements. Herein, high-resolution mass spectrometry-based methods applied in current chemical exposome studies have been surveyed and are shown to be limited. Notably, liquid chromatography separations almost exclusively employ reversed-phase C18 columns using water/methanol gradients with formic acid additive, while gas chromatography is underexploited in the field at this stage. A systematic evaluation of strategies applied in related disciplines (i.e. metabolomics, proteomics, multiresidue trace analysis) was undertaken to provide practical guidance for the development of chemical exposomics. The approaches were assessed on the basis of their costs (i.e. capital expenditure, overhead and maintenance fees, expertise required, consumables) and potential benefits (i.e. improvements to sensitivity, coverage, reproducibility, throughput, ease of use) to prioritize those with promise for chemical exposomics application. Alongside a need for technological investments (e.g. advanced hardware updates), numerous low-cost strategies showed high potential benefits (e.g. different column phases, enhanced sample fractionation) and are feasible for rapid adoption.

Links

• EF16_027/0008360, research and development project: Name: Postdoc@MUNI
• EF17_043/0009632, research and development project: Name: CETOCOEN Excellence
• EF20_079/0017045, research and development project: Name: MSCAfellow4@MUNI
• LM2018121, research and development project: Name: Výzkumná infrastruktura RECETOX (Acronym: RECETOX RI)

Investor: Ministry of Education, Youth and Sports of the CR, RECETOX RI

• 874627, interní kód MU: Name: EXposome Powered tools for healthy living in urbAN SEttings (Acronym: EXPANSE)

Investor: European Union, Health, demographic change and wellbeing (Societal Challenges)