Polyphenolic grape stalk and coffee extracts attenuate spinal
cord injury‑induced neuropathic pain development in ICR‑CD1
female mice

J 2022

Polyphenolic grape stalk and coffee extracts attenuate spinal cord injury‑induced neuropathic pain development in ICR‑CD1 female mice

BAGÓ MAS, Anna, Andrea KORIMOVÁ, Meritxell DEULOFEU FIGUERAS, Enrico VERDÚ, Núria FIOL et. al.

Basic information

Original name

Polyphenolic grape stalk and coffee extracts attenuate spinal cord injury‑induced neuropathic pain development in ICR‑CD1 female mice

Authors

BAGÓ MAS, Anna (724 Spain), Andrea KORIMOVÁ (703 Slovakia, belonging to the institution), Meritxell DEULOFEU FIGUERAS (724 Spain), Enrico VERDÚ (724 Spain), Núria FIOL (203 Czech Republic), Viktorie SVOBODOVÁ (203 Czech Republic, belonging to the institution), Petr DUBOVÝ (203 Czech Republic, guarantor, belonging to the institution) and Pere BOADAS-VAELLO (724 Spain)

Edition

Scientific Reports, Berlin, Nature, 2022, 2045-2322

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30103 Neurosciences

Country of publisher

United Kingdom of Great Britain and Northern Ireland

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 4.600

RIV identification code

RIV/00216224:14110/22:00127909

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.1038/s41598-022-19109-4

UT WoS

000849436000038

Keywords in English

GALLIC ACID; CHLOROGENIC ACID; INFLAMMATORY RESPONSES; CENTRAL SENSITIZATION; DORSAL-HORN; CATHEPSIN-S; EXPRESSION; MICROGLIA; FRACTALKINE; PREVALENCE

Abstract

V originále

More than half of spinal cord injury (SCI) patients develop central neuropathic pain (CNP), which is largely refractory to current treatments. Considering the preclinical evidence showing that polyphenolic compounds may exert antinociceptive effects, the present work aimed to study preventive effects on SCI-induced CNP development by repeated administration of two vegetal polyphenolic extracts: grape stalk extract (GSE) and coffee extract (CE). Thermal hyperalgesia and mechanical allodynia were evaluated at 7, 14 and 21 days postinjury. Then, gliosis, ERK phosphorylation and the expression of CCL2 and CX3CL1 chemokines and their receptors, CCR2 and CX3CR1, were analyzed in the spinal cord. Gliosis and CX3CL1/CX3CR1 expression were also analyzed in the anterior cingulate cortex (ACC) and periaqueductal gray matter (PAG) since they are supraspinal structures involved in pain perception and modulation. GSE and CE treatments modulated pain behaviors accompanied by reduced gliosis in the spinal cord and both treatments modulated neuronglia crosstalk-related biomolecules expression. Moreover, both extracts attenuated astrogliosis in the ACC and PAG as well as microgliosis in the ACC with an increased M2 subpopulation of microglial cells in the PAG. Finally, GSE and CE prevented CX3CL1/CX3CR1 upregulation in the PAG, and modulated their expression in ACC. These findings suggest that repeated administrations of either GSE or CE after SCI may be suitable pharmacologic strategies to attenuate SCI-induced CNP development by means of spinal and supraspinal neuroinflammation modulation.

Citovat

BAGÓ MAS, Anna, Andrea KORIMOVÁ, Meritxell DEULOFEU FIGUERAS, Enrico VERDÚ, Núria FIOL, Viktorie SVOBODOVÁ, Petr DUBOVÝ and Pere BOADAS-VAELLO. Polyphenolic grape stalk and coffee extracts attenuate spinal cord injury‑induced neuropathic pain development in ICR‑CD1 female mice. Scientific Reports. Berlin: Nature, 2022, vol. 12, No 1, p. 1-21. ISSN 2045-2322. Available from: https://dx.doi.org/10.1038/s41598-022-19109-4.

@article{2245741,
   author = {Bagó Mas, Anna and Korimová, Andrea and Deulofeu Figueras, Meritxell and Verdú, Enrico and Fiol, Núria and Svobodová, Viktorie and Dubový, Petr and BoadasandVaello, Pere},
   article_location = {Berlin},
   article_number = {1},
   doi = {http://dx.doi.org/10.1038/s41598-022-19109-4},
   keywords = {GALLIC ACID; CHLOROGENIC ACID; INFLAMMATORY RESPONSES; CENTRAL SENSITIZATION; DORSAL-HORN; CATHEPSIN-S; EXPRESSION; MICROGLIA; FRACTALKINE; PREVALENCE},
   language = {eng},
   issn = {2045-2322},
   journal = {Scientific Reports},
   title = {Polyphenolic grape stalk and coffee extracts attenuate spinal cord injury‑induced neuropathic pain development in ICR‑CD1 female mice},
   url = {https://www.webofscience.com/wos/woscc/full-record/WOS:000849436000038},
   volume = {12},
   year = {2022}
}

TY  - JOUR
ID  - 2245741
AU  - Bagó Mas, Anna - Korimová, Andrea - Deulofeu Figueras, Meritxell - Verdú, Enrico - Fiol, Núria - Svobodová, Viktorie - Dubový, Petr - Boadas-Vaello, Pere
PY  - 2022
TI  - Polyphenolic grape stalk and coffee extracts attenuate spinal cord injury‑induced neuropathic pain development in ICR‑CD1 female mice
JF  - Scientific Reports
VL  - 12
IS  - 1
SP  - 1-21
EP  - 1-21
PB  - Nature
SN  - 20452322
KW  - GALLIC ACID
KW  - CHLOROGENIC ACID
KW  - INFLAMMATORY RESPONSES
KW  - CENTRAL SENSITIZATION
KW  - DORSAL-HORN
KW  - CATHEPSIN-S
KW  - EXPRESSION
KW  - MICROGLIA
KW  - FRACTALKINE
KW  - PREVALENCE
UR  - https://www.webofscience.com/wos/woscc/full-record/WOS:000849436000038
N2  - More than half of spinal cord injury (SCI) patients develop central neuropathic pain (CNP), which is largely refractory to current treatments. Considering the preclinical evidence showing that polyphenolic compounds may exert antinociceptive effects, the present work aimed to study preventive effects on SCI-induced CNP development by repeated administration of two vegetal polyphenolic extracts: grape stalk extract (GSE) and coffee extract (CE). Thermal hyperalgesia and mechanical allodynia were evaluated at 7, 14 and 21 days postinjury. Then, gliosis, ERK phosphorylation and the expression of CCL2 and CX3CL1 chemokines and their receptors, CCR2 and CX3CR1, were analyzed in the spinal cord. Gliosis and CX3CL1/CX3CR1 expression were also analyzed in the anterior cingulate cortex (ACC) and periaqueductal gray matter (PAG) since they are supraspinal structures involved in pain perception and modulation. GSE and CE treatments modulated pain behaviors accompanied by reduced gliosis in the spinal cord and both treatments modulated neuronglia crosstalk-related biomolecules expression. Moreover, both extracts attenuated astrogliosis in the ACC and PAG as well as microgliosis in the ACC with an increased M2 subpopulation of microglial cells in the PAG. Finally, GSE and CE prevented CX3CL1/CX3CR1 upregulation in the PAG, and modulated their expression in ACC. These findings suggest that repeated administrations of either GSE or CE after SCI may be suitable pharmacologic strategies to attenuate SCI-induced CNP development by means of spinal and supraspinal neuroinflammation modulation.
ER  -

BAGÓ MAS, Anna, Andrea KORIMOVÁ, Meritxell DEULOFEU FIGUERAS, Enrico VERDÚ, Núria FIOL, Viktorie SVOBODOVÁ, Petr DUBOVÝ and Pere BOADAS-VAELLO. Polyphenolic grape stalk and coffee extracts attenuate spinal cord injury‑induced neuropathic pain development in ICR‑CD1 female mice. \textit{Scientific Reports}. Berlin: Nature, 2022, vol.~12, No~1, p.~1-21. ISSN~2045-2322. Available from: https://dx.doi.org/10.1038/s41598-022-19109-4.

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