Detailed Information on Publication Record
2022
Central Neuropathic Pain Development Modulation Using Coffee Extract Major Polyphenolic Compounds in Spinal‐Cord‐Injured Female Mice
SOLER‐MARTÍNEZ, Roger, Meritxell DEULOFEU FIGUERAS, Anna BAGÓ MAS, Petr DUBOVÝ, Enrique VERDÚ et. al.Basic information
Original name
Central Neuropathic Pain Development Modulation Using Coffee Extract Major Polyphenolic Compounds in Spinal‐Cord‐Injured Female Mice
Authors
SOLER‐MARTÍNEZ, Roger (724 Spain), Meritxell DEULOFEU FIGUERAS (724 Spain), Anna BAGÓ MAS (724 Spain), Petr DUBOVÝ (203 Czech Republic, guarantor, belonging to the institution), Enrique VERDÚ (724 Spain), Núria FIOL (724 Spain) and Pere BOADAS-VAELLO (724 Spain)
Edition
Biology, Basel, MDPI, 2022, 2079-7737
Other information
Language
English
Type of outcome
Článek v odborném periodiku
Field of Study
30103 Neurosciences
Country of publisher
Switzerland
Confidentiality degree
není předmětem státního či obchodního tajemství
References:
Impact factor
Impact factor: 4.200
RIV identification code
RIV/00216224:14110/22:00127914
Organization unit
Faculty of Medicine
UT WoS
000894690700001
Keywords in English
neuropathic pain; spinal cord injury; polyphenols; coffee extract; chlorogenic acid; neochlorogenic acid; 4-O-caffeoylquinic acid; gliosis
Tags
International impact, Reviewed
Změněno: 14/3/2023 08:17, Mgr. Tereza Miškechová
Abstract
V originále
It was recently shown that coffee polyphenolic extract exerts preventive effects on central neuropathic pain development, but it is unknown whether its beneficial effects are associated with only one of its major polyphenolic compounds or if the whole extract is needed to exert such effects. The main objective of this study was to determine whether the separate administration of major polyphenols from coffee extract exerts preventive effects on the development of central neuropathic pain in mice compared with the effects of the whole coffee extract. Thus, spinal‐cord‐injured female ICR‐CD1 mice were daily treated with either coffee extract or its major polyphenolic compounds during the first week, and reflexive and nonreflexive pain responses were evaluated within the acute phase of spinal cord injury. In addition, the injury‐induced gliosis and dorsal horn sprouting were evaluated with immunohistochemistry. The results showed that the coffee extract prevented spinal cord injury‐induced neuropathic pain, whereas its major polyphenolic compounds resulted in reflexive pain response attenuation. Both preventive and attenuation effects were associated with gliosis and afferent fiber sprouting modulation. Overall, the results suggested that coffee extract effects may be associated with potential synergistic mechanisms exerted by its major polyphenolic compounds and not by the sole effect of only one of them.