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@article{2245764,
author = {Soler‐Martínez, Roger and Deulofeu Figueras, Meritxell and Bagó Mas, Anna and Dubový, Petr and Verdú, Enrique and Fiol, Núria and BoadasandVaello, Pere},
article_location = {Basel},
article_number = {11},
doi = {http://dx.doi.org/10.3390/biology11111617},
keywords = {neuropathic pain; spinal cord injury; polyphenols; coffee extract; chlorogenic acid; neochlorogenic acid; 4-O-caffeoylquinic acid; gliosis},
language = {eng},
issn = {2079-7737},
journal = {Biology},
title = {Central Neuropathic Pain Development Modulation Using Coffee Extract Major Polyphenolic Compounds in Spinal‐Cord‐Injured Female Mice},
url = {https://www.mdpi.com/2079-7737/11/11/1617},
volume = {11},
year = {2022}
}
TY - JOUR
ID - 2245764
AU - Soler‐Martínez, Roger - Deulofeu Figueras, Meritxell - Bagó Mas, Anna - Dubový, Petr - Verdú, Enrique - Fiol, Núria - Boadas-Vaello, Pere
PY - 2022
TI - Central Neuropathic Pain Development Modulation Using Coffee Extract Major Polyphenolic Compounds in Spinal‐Cord‐Injured Female Mice
JF - Biology
VL - 11
IS - 11
SP - 1-19
EP - 1-19
PB - MDPI
SN - 20797737
KW - neuropathic pain
KW - spinal cord injury
KW - polyphenols
KW - coffee extract
KW - chlorogenic acid
KW - neochlorogenic acid
KW - 4-O-caffeoylquinic acid
KW - gliosis
UR - https://www.mdpi.com/2079-7737/11/11/1617
N2 - It was recently shown that coffee polyphenolic extract exerts preventive effects on central neuropathic pain development, but it is unknown whether its beneficial effects are associated with only one of its major polyphenolic compounds or if the whole extract is needed to exert such effects. The main objective of this study was to determine whether the separate administration of major polyphenols from coffee extract exerts preventive effects on the development of central neuropathic pain in mice compared with the effects of the whole coffee extract. Thus, spinal‐cord‐injured female ICR‐CD1 mice were daily treated with either coffee extract or its major polyphenolic compounds during the first week, and reflexive and nonreflexive pain responses were evaluated within the acute phase of spinal cord injury. In addition, the injury‐induced gliosis and dorsal horn sprouting were evaluated with immunohistochemistry. The results showed that the coffee extract prevented spinal cord injury‐induced neuropathic pain, whereas its major polyphenolic compounds resulted in reflexive pain response attenuation. Both preventive and attenuation effects were associated with gliosis and afferent fiber sprouting modulation. Overall, the results suggested that coffee extract effects may be associated with potential synergistic mechanisms exerted by its major polyphenolic compounds and not by the sole effect of only one of them.
ER -
SOLER‐MARTÍNEZ, Roger, Meritxell DEULOFEU FIGUERAS, Anna BAGÓ MAS, Petr DUBOVÝ, Enrique VERDÚ, Núria FIOL and Pere BOADAS-VAELLO. Central Neuropathic Pain Development Modulation Using Coffee Extract Major Polyphenolic Compounds in Spinal‐Cord‐Injured Female Mice. \textit{Biology}. Basel: MDPI, 2022, vol.~11, No~11, p.~1-19. ISSN~2079-7737. Available from: https://dx.doi.org/10.3390/biology11111617.
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