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@article{2245781,
author = {Gál, Peter and Brábek, Jan and Holub, Michal and Jakoubek, Milan and Šedo, Aleksi and Lacina, Lukáš and Strnadová, Karolina and Dubový, Petr and Hornychová, Helena and Ryška, Aleš and Smetana jr., Karel},
article_location = {NEW YORK},
article_number = {5},
doi = {http://dx.doi.org/10.1007/s00418-022-02140-x},
keywords = {Wound healing; Granulation tissue; Peripheral nerve injury; Rheumatoid arthritis; Cancer stroma; SARSCoV- 2; Myofibroblast; IL-6; Inflammation},
language = {eng},
issn = {0948-6143},
journal = {Histochemistry and Cell Biology},
title = {Autoimmunity, cancer and COVID‑19 abnormally activate wound healing pathways: critical role of inflammation},
url = {https://link.springer.com/article/10.1007/s00418-022-02140-x},
volume = {158},
year = {2022}
}
TY - JOUR
ID - 2245781
AU - Gál, Peter - Brábek, Jan - Holub, Michal - Jakoubek, Milan - Šedo, Aleksi - Lacina, Lukáš - Strnadová, Karolina - Dubový, Petr - Hornychová, Helena - Ryška, Aleš - Smetana jr., Karel
PY - 2022
TI - Autoimmunity, cancer and COVID‑19 abnormally activate wound healing pathways: critical role of inflammation
JF - Histochemistry and Cell Biology
VL - 158
IS - 5
SP - 415-434
EP - 415-434
PB - SPRINGER
SN - 09486143
KW - Wound healing
KW - Granulation tissue
KW - Peripheral nerve injury
KW - Rheumatoid arthritis
KW - Cancer stroma
KW - SARSCoV- 2
KW - Myofibroblast
KW - IL-6
KW - Inflammation
UR - https://link.springer.com/article/10.1007/s00418-022-02140-x
N2 - Recent evidence indicates that targeting IL-6 provides broad therapeutic approaches to several diseases. In patients with cancer, autoimmune diseases, severe respiratory infections [e.g. coronavirus disease 2019 (COVID-19)] and wound healing, IL-6 plays a critical role in modulating the systemic and local microenvironment. Elevated serum levels of IL-6 interfere with the systemic immune response and are associated with disease progression and prognosis. As already noted, monoclonal antibodies blocking either IL-6 or binding of IL-6 to receptors have been used/tested successfully in the treatment of rheumatoid arthritis, many cancer types, and COVID-19. Therefore, in the present review, we compare the impact of IL-6 and anti-IL-6 therapy to demonstrate common (pathological) features of the studied diseases such as formation of granulation tissue with the presence of myofibroblasts and deposition of new extracellular matrix. We also discuss abnormal activation of other wound-healing-related pathways that have been implicated in autoimmune disorders, cancer or COVID-19.
ER -
GÁL, Peter, Jan BRÁBEK, Michal HOLUB, Milan JAKOUBEK, Aleksi ŠEDO, Lukáš LACINA, Karolina STRNADOVÁ, Petr DUBOVÝ, Helena HORNYCHOVÁ, Aleš RYŠKA and Karel SMETANA JR. Autoimmunity, cancer and COVID‑19 abnormally activate wound healing pathways: critical role of inflammation. \textit{Histochemistry and Cell Biology}. NEW YORK: SPRINGER, 2022, vol.~158, No~5, p.~415-434. ISSN~0948-6143. Available from: https://dx.doi.org/10.1007/s00418-022-02140-x.
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