| SPIŠAKOVÁ, Viktória, Lukáš HEJTMÁNEK and Jakub HYNŠT. Nextflow in Bioinformatics: Executors Performance Comparison Using Genomics Data. FUTURE GENERATION COMPUTER SYSTEMS-THE INTERNATIONAL JOURNAL OF ESCIENCE. NETHERLANDS: ELSEVIER, 2023, vol. 142, May 2023, p. 328-339. ISSN 0167-739X. Available from: https://dx.doi.org/10.1016/j.future.2023.01.009. |
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@article{2246279,
author = {Spišaková, Viktória and Hejtmánek, Lukáš and Hynšt, Jakub},
article_location = {NETHERLANDS},
article_number = {May 2023},
doi = {http://dx.doi.org/10.1016/j.future.2023.01.009},
keywords = {Kubernetes;HPC;Cloud;Performance comparison;Genomics;Nextflow;Big data},
language = {eng},
issn = {0167-739X},
journal = {FUTURE GENERATION COMPUTER SYSTEMS-THE INTERNATIONAL JOURNAL OF ESCIENCE},
title = {Nextflow in Bioinformatics: Executors Performance Comparison Using Genomics Data},
url = {https://www.sciencedirect.com/journal/future-generation-computer-systems/special-issue/10KV6BLSVBL},
volume = {142},
year = {2023}
}
TY - JOUR
ID - 2246279
AU - Spišaková, Viktória - Hejtmánek, Lukáš - Hynšt, Jakub
PY - 2023
TI - Nextflow in Bioinformatics: Executors Performance Comparison Using Genomics Data
JF - FUTURE GENERATION COMPUTER SYSTEMS-THE INTERNATIONAL JOURNAL OF ESCIENCE
VL - 142
IS - May 2023
SP - 328-339
EP - 328-339
PB - ELSEVIER
SN - 0167739X
KW - Kubernetes;HPC;Cloud;Performance comparison;Genomics;Nextflow;Big data
UR - https://www.sciencedirect.com/journal/future-generation-computer-systems/special-issue/10KV6BLSVBL
N2 - Processing big data is a computationally demanding task which has usually been fulfilled by HPC batch systems. These complex systems pose a challenge to scientists due to their cumbersome nature and changing environment. The scientists often lack deeper informatics understanding and experiment reproducibility is increasingly becoming a hard request on the research validity. A new computational paradigm — containers — are meant to contain all dependencies and persist the state which help reproducibility. They have gained a lot of popularity in the informatics community but HPC community remains skeptical and doubts that container platforms are appropriate for demanding tasks or that such infrastructure can reach significant performance. In this paper, we observe the performance of various infrastructure types (HPC, Kubernetes, local) on a Sarek Nextflow bioinformatics workflow with real life genomics data of various sizes. We analyze obtained workload trace and discuss pros and cons of utilized infrastructures. We also show some approaches perform better in terms of available resources but others are more suitable for diversified workflows. Based on the results, we provide recommendations for life science groups which plan to analyze data in large scale.
ER -
SPIŠAKOVÁ, Viktória, Lukáš HEJTMÁNEK and Jakub HYNŠT. Nextflow in Bioinformatics: Executors Performance Comparison Using Genomics Data. \textit{FUTURE GENERATION COMPUTER SYSTEMS-THE INTERNATIONAL JOURNAL OF ESCIENCE}. NETHERLANDS: ELSEVIER, 2023, vol.~142, May 2023, p.~328-339. ISSN~0167-739X. Available from: https://dx.doi.org/10.1016/j.future.2023.01.009.
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