| POLOCZKOVÁ, Hana, Jan KREJČÍ, Petr HUDE, Eva OZÁBALOVÁ, Július GODAVA, Tomáš HONEK, Víta ŽAMPACHOVÁ, Iva SVOBODOVÁ, Tomáš FREIBERGER and Lenka ŠPINAROVÁ. Effect of immunosuppressive therapy in inflammatory cardiomyopathy: data from The Czech Inflammatory Cardiomyopathy Immunosuppressive Trial. Bratislava Medical Journal - Bratislavské lekárske listy. BRATISLAVA: Univerzita Komenského, 2022, vol. 123, No 1, p. 37-43. ISSN 0006-9248. Available from: https://dx.doi.org/10.4149/BLL_2022_006. |
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@article{2247018,
author = {Poloczková, Hana and Krejčí, Jan and Hude, Petr and Ozábalová, Eva and Godava, Július and Honek, Tomáš and Žampachová, Víta and Svobodová, Iva and Freiberger, Tomáš and Špinarová, Lenka},
article_location = {BRATISLAVA},
article_number = {1},
doi = {http://dx.doi.org/10.4149/BLL_2022_006},
keywords = {myocarditis; inflammatory cardiomyopathy; endomyocardial biopsy; immunosuppressive therapy},
language = {eng},
issn = {0006-9248},
journal = {Bratislava Medical Journal - Bratislavské lekárske listy},
title = {Effect of immunosuppressive therapy in inflammatory cardiomyopathy: data from The Czech Inflammatory Cardiomyopathy Immunosuppressive Trial},
url = {http://www.elis.sk/index.php?page=shop.product_details&flypage=flypage.tpl&product_id=7503&category_id=179&option=com_virtuemart&vmcchk=1&Itemid=1},
volume = {123},
year = {2022}
}
TY - JOUR
ID - 2247018
AU - Poloczková, Hana - Krejčí, Jan - Hude, Petr - Ozábalová, Eva - Godava, Július - Honek, Tomáš - Žampachová, Víta - Svobodová, Iva - Freiberger, Tomáš - Špinarová, Lenka
PY - 2022
TI - Effect of immunosuppressive therapy in inflammatory cardiomyopathy: data from The Czech Inflammatory Cardiomyopathy Immunosuppressive Trial
JF - Bratislava Medical Journal - Bratislavské lekárske listy
VL - 123
IS - 1
SP - 37-43
EP - 37-43
PB - Univerzita Komenského
SN - 00069248
KW - myocarditis
KW - inflammatory cardiomyopathy
KW - endomyocardial biopsy
KW - immunosuppressive therapy
UR - http://www.elis.sk/index.php?page=shop.product_details&flypage=flypage.tpl&product_id=7503&category_id=179&option=com_virtuemart&vmcchk=1&Itemid=1
N2 - INTRODUCTION: The indications for specific treatment in the cases of inflammatory cardiomyopathy are based on limited data from several small clinical trials. AIM: A comparison of the effect of two dose regimens of combined immunosuppressive therapy by adding them to conventional heart failure therapy and comparing them with conventional heart failure therapy alone in patients with inflammatory cardiomyopathy. METHODS AND STUDY POPULATION: We enrolled 20 patients; mean age 46.10 +/- 7.33 years, duration of symptoms <6 months, LVEF <= 40 %, NYHA class II-IV, with biopsy-proven myocarditis. Patients were randomly separated into groups treated with immunosuppressive therapy in addition to conventional heart failure therapy or to a group treated with conventional heart failure therapy alone. Clinical and echocardiographic parameters were evaluated. RESULTS: The baseline values of LVEF in the group of immunosuppressive therapy (LVEF 22.3 +/- 4.7 %) were similar to those in the group treated with conventional heart failure therapy (LVEF 21.7 +/- 4.7 %; p=0.757). After twelve months there was no statistically significant difference in LVEF between the two studied groups (LVEF 33.7 +/- 9.5 % for the immunosuppressive therapy group and 41.3 +/- 13.0 % for the conventional therapy group; p=0.175). CONCLUSION: In our study population, we proved no positive effect of combined immunosuppressive therapy on the left ventricular function over 12 months. The main limitation of the study is the small number of enrolled patients.
ER -
POLOCZKOVÁ, Hana, Jan KREJČÍ, Petr HUDE, Eva OZÁBALOVÁ, Július GODAVA, Tomáš HONEK, Víta ŽAMPACHOVÁ, Iva SVOBODOVÁ, Tomáš FREIBERGER and Lenka ŠPINAROVÁ. Effect of immunosuppressive therapy in inflammatory cardiomyopathy: data from The Czech Inflammatory Cardiomyopathy Immunosuppressive Trial. \textit{Bratislava Medical Journal - Bratislavské lekárske listy}. BRATISLAVA: Univerzita Komenského, 2022, vol.~123, No~1, p.~37-43. ISSN~0006-9248. Available from: https://dx.doi.org/10.4149/BLL\_{}2022\_{}006.
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