J 2022

Malignant complications of celiac disease: a case series and review of the literature

PACKOVÁ, Barbora, Pavel KOHOUT, Milan DASTYCH, Jitka PROKEŠOVÁ, Tomáš GROLICH et. al.

Basic information

Original name

Malignant complications of celiac disease: a case series and review of the literature

Authors

PACKOVÁ, Barbora (203 Czech Republic, belonging to the institution), Pavel KOHOUT (203 Czech Republic), Milan DASTYCH (203 Czech Republic, belonging to the institution), Jitka PROKEŠOVÁ (203 Czech Republic, belonging to the institution), Tomáš GROLICH (203 Czech Republic, belonging to the institution) and Radek KROUPA (203 Czech Republic, belonging to the institution)

Edition

Journal of Medical Case Reports, London, BMC, 2022, 1752-1947

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30219 Gastroenterology and hepatology

Country of publisher

United States of America

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

Impact factor

Impact factor: 1.000

RIV identification code

RIV/00216224:14110/22:00128049

Organization unit

Faculty of Medicine

DOI

UT WoS

000897934500001

Keywords in English

Celiac disease; Malignancy; Complication; Lymphoma; Carcinoma; Case report

Tags

Tags

International impact, Reviewed
Změněno: 20/1/2023 12:00, Mgr. Tereza Miškechová

Abstract

V originále

Abstract Background: Celiac disease is an immune-mediated enteropathy triggered by gluten in genetically susceptible individuals. Diagnosis is based on evaluating specifc autoantibodies and histopathologic fndings of duodenal biopsy specimens. The only therapy for celiac disease is a gluten-free diet. Celiac disease can be complicated by malnutrition, other autoimmune diseases, refractoriness to treatment, and gastrointestinal tumors. This article presents seven cases of malignancies in patients with celiac disease. Its objective is to raise awareness of the malignant complications of celiac disease, leading to earlier diagnosis and improved outcomes. Case presentation: Seven cases of malignant complications of celiac disease occurred among 190 patients followed at the Department of Internal Medicine and Gastroenterology, University Hospital Brno from 2014 to 2021. We describe these cases and the presentation, diagnostic process, course, management, and outcomes for each, along with proposed potential risk factors of malignant complications. There was one Caucasian man who was 70 years old and six Caucasian women who were 36, 46, 48, 55, 73, and 82 years old in our cohort. Of the seven cases of malignancies in our cohort, four patients were diagnosed with small bowel adenocarcinoma, one with difuse large B-cell lymphoma, one with carcinoma of the tongue, and one with colorectal carcinoma. Conclusions: Malignancies occurred in 3.7% of patients followed up for celiac disease. Awareness of the malignant complications of celiac disease, risk factors, presentation, and disease course could lead to earlier diagnosis and improved outcomes.