Anesthetized Guinea Pig as a Model for Drug Testing

BARTÁKOVÁ, Anna, Marie NOVÁKOVÁ and Tibor STRAČINA. Anesthetized Guinea Pig as a Model for Drug Testing. Physiological Research. PRAGUE: ACAD SCIENCES CZECH REPUBLIC, 2022, vol. 71, Supplement 2, p. "S211"-"S218", 8 pp. ISSN 0862-8408. Available from: https://dx.doi.org/10.33549/physiolres.934994.

Basic information

• Original name: Anesthetized Guinea Pig as a Model for Drug Testing
• Authors: BARTÁKOVÁ, Anna (203 Czech Republic, belonging to the institution), Marie NOVÁKOVÁ (203 Czech Republic, belonging to the institution) and Tibor STRAČINA (703 Slovakia, guarantor, belonging to the institution).
• Edition: Physiological Research, PRAGUE, ACAD SCIENCES CZECH REPUBLIC, 2022, 0862-8408.

Other information

• Original language: English
• Type of outcome: Article in a journal
• Field of Study: 30105 Physiology
• Country of publisher: Czech Republic
• Confidentiality degree: is not subject to a state or trade secret
• WWW: URL
• Impact factor: Impact factor: 2.100
• RIV identification code: RIV/00216224:14110/22:00128065
• Organization unit: Faculty of Medicine
• Doi: http://dx.doi.org/10.33549/physiolres.934994
• UT WoS: 000924861700006
• Keywords in English: Adrenergic agents; Animal model; Cardiovascular system; Drug testing; Guinea pig
• Tags: 14110515, rivok
• Tags: International impact, Reviewed

Abstract

Based on the World Health Organization statistics, cardiovascular diseases represent the major cause of death worldwide. Although a wide range of treatment approaches and pharmaceuticals is available, the therapy is often not effective enough and therefore health risks for the patient persist. Thus, it is still essential to test new drug candidates for the treatment of various pathophysiological conditions related to cardiovascular system. In vivo models represent indispensable part of preclinical testing of such substances. Anesthetized guinea pig as a whole-body model allows to evaluate complex reactions of cardiovascular system to tested substance. Moreover, action potential of guinea pig cardiomyocyte is quite comparable to that of human. Hence, the results from this model are then quite well translatable to clinical medicine. Aim of this paper was to summarize the methodology of this model, including its advantages and/or limitations and risks, based on the effects of two substances with adrenergic activity on the ECG parameters. The model of anesthetized guinea pig proved to be valuable and suitable for testing of drugs with cardiovascular effects.

Links

• EF19_073/0016943, research and development project: Name: Interní grantová agentura Masarykovy univerzity
• MUNI/IGA/1098/2020, interní kód MU: Name: Arrhythmogenic potential of TP-1 in animal model

Investor: Masaryk University