Anesthetized Guinea Pig as a Model for Drug Testing

J 2022

Anesthetized Guinea Pig as a Model for Drug Testing

BARTÁKOVÁ, Anna, Marie NOVÁKOVÁ and Tibor STRAČINA

Basic information

Original name

Anesthetized Guinea Pig as a Model for Drug Testing

Authors

BARTÁKOVÁ, Anna (203 Czech Republic, belonging to the institution), Marie NOVÁKOVÁ (203 Czech Republic, belonging to the institution) and Tibor STRAČINA (703 Slovakia, guarantor, belonging to the institution)

Edition

Physiological Research, PRAGUE, ACAD SCIENCES CZECH REPUBLIC, 2022, 0862-8408

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30105 Physiology

Country of publisher

Czech Republic

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 2.100

RIV identification code

RIV/00216224:14110/22:00128065

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.33549/physiolres.934994

UT WoS

000924861700006

Keywords in English

Adrenergic agents; Animal model; Cardiovascular system; Drug testing; Guinea pig

Abstract

V originále

Based on the World Health Organization statistics, cardiovascular diseases represent the major cause of death worldwide. Although a wide range of treatment approaches and pharmaceuticals is available, the therapy is often not effective enough and therefore health risks for the patient persist. Thus, it is still essential to test new drug candidates for the treatment of various pathophysiological conditions related to cardiovascular system. In vivo models represent indispensable part of preclinical testing of such substances. Anesthetized guinea pig as a whole-body model allows to evaluate complex reactions of cardiovascular system to tested substance. Moreover, action potential of guinea pig cardiomyocyte is quite comparable to that of human. Hence, the results from this model are then quite well translatable to clinical medicine. Aim of this paper was to summarize the methodology of this model, including its advantages and/or limitations and risks, based on the effects of two substances with adrenergic activity on the ECG parameters. The model of anesthetized guinea pig proved to be valuable and suitable for testing of drugs with cardiovascular effects.

Links

EF19_073/0016943, research and development project

Name: Interní grantová agentura Masarykovy univerzity

MUNI/IGA/1098/2020, interní kód MU

Name: Arrhythmogenic potential of TP-1 in animal model

Investor: Masaryk University

Citovat

BARTÁKOVÁ, Anna, Marie NOVÁKOVÁ and Tibor STRAČINA. Anesthetized Guinea Pig as a Model for Drug Testing. Physiological Research. PRAGUE: ACAD SCIENCES CZECH REPUBLIC, 2022, vol. 71, Supplement 2, p. "S211"-"S218", 8 pp. ISSN 0862-8408. Available from: https://dx.doi.org/10.33549/physiolres.934994.

@article{2247518,
   author = {Bartáková, Anna and Nováková, Marie and Stračina, Tibor},
   article_location = {PRAGUE},
   article_number = {Supplement 2},
   doi = {http://dx.doi.org/10.33549/physiolres.934994},
   keywords = {Adrenergic agents; Animal model; Cardiovascular system; Drug testing; Guinea pig},
   language = {eng},
   issn = {0862-8408},
   journal = {Physiological Research},
   title = {Anesthetized Guinea Pig as a Model for Drug Testing},
   url = {https://www.biomed.cas.cz/physiolres/pdf/2022/71_S211.pdf},
   volume = {71},
   year = {2022}
}

TY  - JOUR
ID  - 2247518
AU  - Bartáková, Anna - Nováková, Marie - Stračina, Tibor
PY  - 2022
TI  - Anesthetized Guinea Pig as a Model for Drug Testing
JF  - Physiological Research
VL  - 71
IS  - Supplement 2
SP  - "S211"-"S218"
EP  - "S211"-"S218"
PB  - ACAD SCIENCES CZECH REPUBLIC
SN  - 08628408
KW  - Adrenergic agents
KW  - Animal model
KW  - Cardiovascular system
KW  - Drug testing
KW  - Guinea pig
UR  - https://www.biomed.cas.cz/physiolres/pdf/2022/71_S211.pdf
N2  - Based on the World Health Organization statistics, cardiovascular diseases represent the major cause of death worldwide. Although a wide range of treatment approaches and pharmaceuticals is available, the therapy is often not effective enough and therefore health risks for the patient persist. Thus, it is still essential to test new drug candidates for the treatment of various pathophysiological conditions related to cardiovascular system. In vivo models represent indispensable part of preclinical testing of such substances. Anesthetized guinea pig as a whole-body model allows to evaluate complex reactions of cardiovascular system to tested substance. Moreover, action potential of guinea pig cardiomyocyte is quite comparable to that of human. Hence, the results from this model are then quite well translatable to clinical medicine. Aim of this paper was to summarize the methodology of this model, including its advantages and/or limitations and risks, based on the effects of two substances with adrenergic activity on the ECG parameters. The model of anesthetized guinea pig proved to be valuable and suitable for testing of drugs with cardiovascular effects.
ER  -

BARTÁKOVÁ, Anna, Marie NOVÁKOVÁ and Tibor STRAČINA. Anesthetized Guinea Pig as a Model for Drug Testing. \textit{Physiological Research}. PRAGUE: ACAD SCIENCES CZECH REPUBLIC, 2022, vol.~71, Supplement 2, p.~''S211''-''S218'', 8 pp. ISSN~0862-8408. Available from: https://dx.doi.org/10.33549/physiolres.934994.

Detailed Information on Publication Record