Detailed Information on Publication Record
2022
Intra-subject stability of different expressions of spatial QRS-T angle and their relationship to heart rate
ANDRŠOVÁ, Irena, Katerina HNATKOVA, Ondřej TOMAN, Martina ŠIŠÁKOVÁ, Peter SMETANA et. al.Basic information
Original name
Intra-subject stability of different expressions of spatial QRS-T angle and their relationship to heart rate
Authors
ANDRŠOVÁ, Irena (203 Czech Republic, belonging to the institution), Katerina HNATKOVA (203 Czech Republic, guarantor), Ondřej TOMAN (203 Czech Republic, belonging to the institution), Martina ŠIŠÁKOVÁ (203 Czech Republic, belonging to the institution), Peter SMETANA, Katharina M. HUSTER, Petra BARTHEL, Tomáš NOVOTNÝ (203 Czech Republic, belonging to the institution), Georg SCHMIDT and Marek MALÍK (203 Czech Republic, belonging to the institution)
Edition
Frontiers in Physiology, Lausanne, FRONTIERS MEDIA SA, 2022, 1664-042X
Other information
Language
English
Type of outcome
Článek v odborném periodiku
Field of Study
30201 Cardiac and Cardiovascular systems
Country of publisher
Switzerland
Confidentiality degree
není předmětem státního či obchodního tajemství
References:
Impact factor
Impact factor: 4.000
RIV identification code
RIV/00216224:14110/22:00128071
Organization unit
Faculty of Medicine
UT WoS
000874799100001
Keywords in English
healthy volunteers; long-term ECG; ECG measurements; spatial QRS-T angle; heart rate; heart rate hysteresis; polynomial regression; sex differences
Tags
International impact, Reviewed
Změněno: 18/1/2023 09:37, Mgr. Tereza Miškechová
Abstract
V originále
Three-dimensional angle between the QRS complex and T wave vectors is a known powerful cardiovascular risk predictor. Nevertheless, several physiological properties of the angle are unknown or poorly understood. These include, among others, intra-subject profiles and stability of the angle relationship to heart rate, characteristics of angle/heart-rate hysteresis, and the changes of these characteristics with different modes of QRS-T angle calculation. These characteristics were investigated in long-term 12-lead Holter recordings of 523 healthy volunteers (259 females). Three different algorithmic methods for the angle computation were based on maximal vector magnitude of QRS and T wave loops, areas under the QRS complex and T wave curvatures in orthogonal leads, and weighted integration of all QRS and T wave vectors moving around the respective 3-dimensional loops. These methods were applied to orthogonal leads derived either by a uniform conversion matrix or by singular value decomposition (SVD) of the original 12-lead ECG, giving 6 possible ways of expressing the angle. Heart rate hysteresis was assessed using the exponential decay models. All these methods were used to measure the angle in 659,313 representative waveforms of individual 10-s ECG samples and in 7,350,733 individual beats contained in the same 10-s samples. With all measurement methods, the measured angles fitted second-degree polynomial regressions to the underlying heart rate. Independent of the measurement method, the angles were found significantly narrower in females (p < 0.00001) with the differences to males between 10 degrees and 20 degrees, suggesting that in future risk-assessment studies, different angle dichotomies are needed for both sexes. The integrative method combined with SVD leads showed the highest intra-subject reproducibility (p < 0.00001). No reproducible delay between heart rate changes and QRS-T angle changes was found. This was interpreted as a suggestion that the measurement of QRS-T angle might offer direct assessment of cardiac autonomic responsiveness at the ventricular level.
Links
| MUNI/A/1450/2021, interní kód MU |
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