Tremor associated with similar structural networks in
Parkinson's disease and essential tremor

J 2022

Tremor associated with similar structural networks in Parkinson's disease and essential tremor

FILIP, Pavel, Kristina BURDOVA, Zdenek VALENTA, Robert JECH, Viktória KOKOŠOVÁ et. al.

Basic information

Original name

Tremor associated with similar structural networks in Parkinson's disease and essential tremor

Authors

FILIP, Pavel (703 Slovakia, guarantor), Kristina BURDOVA (203 Czech Republic), Zdenek VALENTA (203 Czech Republic), Robert JECH (203 Czech Republic), Viktória KOKOŠOVÁ (703 Slovakia, belonging to the institution), Marek BALÁŽ (703 Slovakia, belonging to the institution), Silvia MANGIA, Shalom MICHAELI, Martin BAREŠ (203 Czech Republic, belonging to the institution) and Lubomír VOJTÍŠEK (203 Czech Republic, belonging to the institution)

Edition

PARKINSONISM & RELATED DISORDERS, OXFORD, ELSEVIER SCI LTD, 2022, 1353-8020

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30210 Clinical neurology

Country of publisher

United Kingdom of Great Britain and Northern Ireland

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 4.100

RIV identification code

RIV/00216224:14110/22:00128076

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.1016/j.parkreldis.2021.12.014

UT WoS

000749847700006

Keywords in English

Tremor; Probabilistic tractography; Structural connectome; Parkinson 's disease; Essential tremor

Abstract

V originále

Introduction: Despite substantial clinical and pathophysiological differences, the characteristics of tremor in Parkinson's disease (PD) and essential tremor (ET) patients bear certain similarities. The presented study delineates tremor-related structural networks in these two disorders. Methods: 42 non-advanced PD patients (18 tremor-dominant, 24 without substantial tremor), 17 ET, and 45 healthy controls underwent high-angular resolution diffusion-weighted imaging acquisition to reconstruct their structural motor connectomes as a proxy of the anatomical interconnections between motor network regions, implementing state-of-the-art globally optimised probabilistic tractography. Results: When compared to healthy controls, ET patients exhibited higher structural connectivity in the cerebellothalamo-cortical network. Interestingly, the comparison of tremor-dominant PD patients and PD patients without tremor yielded very similar results - higher structural connectivity in tremor-dominant PD sharing multiple nodes with the tremor network detected in ET, despite the generally lower structural connectivity between basal ganglia and frontal cortex in the whole PD group when compared to healthy controls. Conclusion: The higher structural connectivity of the cerebello-thalamo-cortical network seems to be the dominant tremor driver in both PD and ET. While it appears to be the only tremor-related network in ET, its combination with large scale hypoconnectivity in the frontal cortico-subcortical network in PD may explain different clinical features of tremor in these two disorders.

Links

691110, interní kód MU

Name: Advanced MR methods for characterization of microstructural brain damage (MICROBRADAM) (Acronym: MICROBRADAM)

Investor: European Union, MSCA Marie Skłodowska-Curie Actions (Excellent Science)

90129, large research infrastructures

Name: Czech-BioImaging II

Citovat

FILIP, Pavel, Kristina BURDOVA, Zdenek VALENTA, Robert JECH, Viktória KOKOŠOVÁ, Marek BALÁŽ, Silvia MANGIA, Shalom MICHAELI, Martin BAREŠ and Lubomír VOJTÍŠEK. Tremor associated with similar structural networks in Parkinson's disease and essential tremor. PARKINSONISM & RELATED DISORDERS. OXFORD: ELSEVIER SCI LTD, 2022, vol. 95, February 2022, p. 28-34. ISSN 1353-8020. Available from: https://dx.doi.org/10.1016/j.parkreldis.2021.12.014.

@article{2247547,
   author = {Filip, Pavel and Burdova, Kristina and Valenta, Zdenek and Jech, Robert and Kokošová, Viktória and Baláž, Marek and Mangia, Silvia and Michaeli, Shalom and Bareš, Martin and Vojtíšek, Lubomír},
   article_location = {OXFORD},
   article_number = {February 2022},
   doi = {http://dx.doi.org/10.1016/j.parkreldis.2021.12.014},
   keywords = {Tremor; Probabilistic tractography; Structural connectome; Parkinson 's disease; Essential tremor},
   language = {eng},
   issn = {1353-8020},
   journal = {PARKINSONISM & RELATED DISORDERS},
   title = {Tremor associated with similar structural networks in Parkinson's disease and essential tremor},
   url = {https://www.sciencedirect.com/science/article/pii/S1353802021004697?via%3Dihub},
   volume = {95},
   year = {2022}
}

TY  - JOUR
ID  - 2247547
AU  - Filip, Pavel - Burdova, Kristina - Valenta, Zdenek - Jech, Robert - Kokošová, Viktória - Baláž, Marek - Mangia, Silvia - Michaeli, Shalom - Bareš, Martin - Vojtíšek, Lubomír
PY  - 2022
TI  - Tremor associated with similar structural networks in Parkinson's disease and essential tremor
JF  - PARKINSONISM & RELATED DISORDERS
VL  - 95
IS  - February 2022
SP  - 28-34
EP  - 28-34
PB  - ELSEVIER SCI LTD
SN  - 13538020
KW  - Tremor
KW  - Probabilistic tractography
KW  - Structural connectome
KW  - Parkinson 's disease
KW  - Essential tremor
UR  - https://www.sciencedirect.com/science/article/pii/S1353802021004697?via%3Dihub
N2  - Introduction: Despite substantial clinical and pathophysiological differences, the characteristics of tremor in Parkinson's disease (PD) and essential tremor (ET) patients bear certain similarities. The presented study delineates tremor-related structural networks in these two disorders. Methods: 42 non-advanced PD patients (18 tremor-dominant, 24 without substantial tremor), 17 ET, and 45 healthy controls underwent high-angular resolution diffusion-weighted imaging acquisition to reconstruct their structural motor connectomes as a proxy of the anatomical interconnections between motor network regions, implementing state-of-the-art globally optimised probabilistic tractography. Results: When compared to healthy controls, ET patients exhibited higher structural connectivity in the cerebellothalamo-cortical network. Interestingly, the comparison of tremor-dominant PD patients and PD patients without tremor yielded very similar results - higher structural connectivity in tremor-dominant PD sharing multiple nodes with the tremor network detected in ET, despite the generally lower structural connectivity between basal ganglia and frontal cortex in the whole PD group when compared to healthy controls. Conclusion: The higher structural connectivity of the cerebello-thalamo-cortical network seems to be the dominant tremor driver in both PD and ET. While it appears to be the only tremor-related network in ET, its combination with large scale hypoconnectivity in the frontal cortico-subcortical network in PD may explain different clinical features of tremor in these two disorders.
ER  -

FILIP, Pavel, Kristina BURDOVA, Zdenek VALENTA, Robert JECH, Viktória KOKOŠOVÁ, Marek BALÁŽ, Silvia MANGIA, Shalom MICHAELI, Martin BAREŠ and Lubomír VOJTÍŠEK. Tremor associated with similar structural networks in Parkinson's disease and essential tremor. \textit{PARKINSONISM \&{} RELATED DISORDERS}. OXFORD: ELSEVIER SCI LTD, 2022, vol.~95, February 2022, p.~28-34. ISSN~1353-8020. Available from: https://dx.doi.org/10.1016/j.parkreldis.2021.12.014.

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