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@article{2247549,
author = {Vaníčková, Lucie and Do, Tomáš and Vejvodová, Markéta and Horák, Vratislav and Hubálek, Martin and Emri, Gabriella and Zemánková, Kristýna and Pavelicová, Kristýna and Křížková, Soňa and Faltusová, Veronika and Pompeiano, Antonio and Vaculovičová, Markéta and Zítka, Ondřej and Vaculovič, Tomáš and Adam, Vojtěch},
article_number = {April},
doi = {http://dx.doi.org/10.1016/j.ijbiomac.2022.01.139},
keywords = {Melanoma; Mass spectrometry; MeLiM},
language = {eng},
issn = {0141-8130},
journal = {International Journal of Biological Macromolecules},
title = {Mapping of MeLiM melanoma combining ICP-MS and MALDI-MSI methods},
url = {https://doi.org/10.1016/j.ijbiomac.2022.01.139},
volume = {203},
year = {2022}
}
TY - JOUR
ID - 2247549
AU - Vaníčková, Lucie - Do, Tomáš - Vejvodová, Markéta - Horák, Vratislav - Hubálek, Martin - Emri, Gabriella - Zemánková, Kristýna - Pavelicová, Kristýna - Křížková, Soňa - Faltusová, Veronika - Pompeiano, Antonio - Vaculovičová, Markéta - Zítka, Ondřej - Vaculovič, Tomáš - Adam, Vojtěch
PY - 2022
TI - Mapping of MeLiM melanoma combining ICP-MS and MALDI-MSI methods
JF - International Journal of Biological Macromolecules
VL - 203
IS - April
SP - 583-592
EP - 583-592
PB - Elsevier
SN - 01418130
KW - Melanoma
KW - Mass spectrometry
KW - MeLiM
UR - https://doi.org/10.1016/j.ijbiomac.2022.01.139
N2 - Here we developed a powerful tool for comprehensive data collection and mapping of molecular and elemental signatures in the Melanoma-bearing Libechov Minipig (MeLiM) model. The combination of different mass spectrometric methods allowed for detail investigation of specific melanoma markers and elements and their spatial distribution in tissue sections. MALDI-MSI combined with HPLC-MS/MS analyses resulted in identification of seven specific proteins, S100A12, CD163, MMP-2, galectin-1, tenascin, resistin and PCNA that were presented in the melanoma signatures. Furthermore, the ICP-MS method allowed for spatial detection of zinc, calcium, copper, and iron elements linked with the allocation of the specific binding proteins.
ER -
VANÍČKOVÁ, Lucie, Tomáš DO, Markéta VEJVODOVÁ, Vratislav HORÁK, Martin HUBÁLEK, Gabriella EMRI, Kristýna ZEMÁNKOVÁ, Kristýna PAVELICOVÁ, Soňa KŘÍŽKOVÁ, Veronika FALTUSOVÁ, Antonio POMPEIANO, Markéta VACULOVIČOVÁ, Ondřej ZÍTKA, Tomáš VACULOVIČ and Vojtěch ADAM. Mapping of MeLiM melanoma combining ICP-MS and MALDI-MSI methods. \textit{International Journal of Biological Macromolecules}. Elsevier, 2022, vol.~203, April, p.~583-592. ISSN~0141-8130. Available from: https://dx.doi.org/10.1016/j.ijbiomac.2022.01.139.
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