Deep brain stimulation of the anterior nuclei of the thalamus
in focal epilepsy

J 2022

Deep brain stimulation of the anterior nuclei of the thalamus in focal epilepsy

DEUTSCHOVÁ, Barbora and Ivan REKTOR

Basic information

Original name

Deep brain stimulation of the anterior nuclei of the thalamus in focal epilepsy

Authors

DEUTSCHOVÁ, Barbora (203 Czech Republic, belonging to the institution) and Ivan REKTOR (203 Czech Republic, guarantor, belonging to the institution)

Edition

Clinical Neurophysiology, Clare, Elsevier Ireland, 2022, 1388-2457

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30210 Clinical neurology

Country of publisher

Ireland

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 4.700

RIV identification code

RIV/00216224:14110/22:00129377

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.1016/j.clinph.2022.09.002

UT WoS

000886064800001

Keywords in English

Anterior thalamic nuclei; Focal epilepsy; Deep brain stimulation

Abstract

V originále

Objective: To review the therapeutic effects of deep brain stimulation of the anterior nuclei of the thala-mus (ANT-DBS) and the predictors of its effectiveness, safety, and adverse effects. Methods: A comprehensive search of the medical literature (PubMed) was conducted to identify relevant articles investigating ANT-DBS therapy for epilepsy. Out of 332 references, 77 focused on focal epilepsies were reviewed. Results: The DBS effect is probably due to decreased synchronization of epileptic activity in the cortex. The potential mechanisms from cellular to brain network levels are presented. The ANT might participate actively in the network elaborating focal seizures. The effects of ANT-DBS differed in various studies; ANT-DBS was linked with a 41% seizure frequency reduction at 1 year, 69% at 5 years, and 75% at 7 years. The most frequently reported adverse effects, depression and memory impairment, were considered non -serious in the long-term follow-up view. ANT-DBS also has been used in a few cases to treat status epilep-ticus. Conclusions: We reviewed the clinical literature and identified several factors that may predict seizure outcome following DBS therapy. More large-scale trials are required since there is a need to explore stim-ulation settings, apply patient-tailored therapy, and identify the presurgical predictors of patient response. Significance: A critical review of the published literature on ANT-DBS in focal epilepsy is presented. ANT-DBS mechanisms are not fully understood; possible explanations are provided. Biomarkers of ANT-DBS effectiveness may lead to patient-tailored therapy.

Links

GA21-25953S, research and development project

Name: Subkortikální jádra a kortikální funkce z perspektivy hluboké mozkové stimulace (Acronym: DBS3D)

Investor: Czech Science Foundation, Subcortical nuclei and cortical functions – insight from the deep brain stimulation perspective

Citovat

DEUTSCHOVÁ, Barbora and Ivan REKTOR. Deep brain stimulation of the anterior nuclei of the thalamus in focal epilepsy. Clinical Neurophysiology. Clare: Elsevier Ireland, 2022, vol. 144, December 2022, p. 1-7. ISSN 1388-2457. Available from: https://dx.doi.org/10.1016/j.clinph.2022.09.002.

@article{2247593,
   author = {Deutschová, Barbora and Rektor, Ivan},
   article_location = {Clare},
   article_number = {December 2022},
   doi = {http://dx.doi.org/10.1016/j.clinph.2022.09.002},
   keywords = {Anterior thalamic nuclei; Focal epilepsy; Deep brain stimulation},
   language = {eng},
   issn = {1388-2457},
   journal = {Clinical Neurophysiology},
   title = {Deep brain stimulation of the anterior nuclei of the thalamus in focal epilepsy},
   url = {https://www.sciencedirect.com/science/article/pii/S1388245722008872?via%3Dihub},
   volume = {144},
   year = {2022}
}

TY  - JOUR
ID  - 2247593
AU  - Deutschová, Barbora - Rektor, Ivan
PY  - 2022
TI  - Deep brain stimulation of the anterior nuclei of the thalamus in focal epilepsy
JF  - Clinical Neurophysiology
VL  - 144
IS  - December 2022
SP  - 1-7
EP  - 1-7
PB  - Elsevier Ireland
SN  - 13882457
KW  - Anterior thalamic nuclei
KW  - Focal epilepsy
KW  - Deep brain stimulation
UR  - https://www.sciencedirect.com/science/article/pii/S1388245722008872?via%3Dihub
N2  - Objective: To review the therapeutic effects of deep brain stimulation of the anterior nuclei of the thala-mus (ANT-DBS) and the predictors of its effectiveness, safety, and adverse effects. Methods: A comprehensive search of the medical literature (PubMed) was conducted to identify relevant articles investigating ANT-DBS therapy for epilepsy. Out of 332 references, 77 focused on focal epilepsies were reviewed. Results: The DBS effect is probably due to decreased synchronization of epileptic activity in the cortex. The potential mechanisms from cellular to brain network levels are presented. The ANT might participate actively in the network elaborating focal seizures. The effects of ANT-DBS differed in various studies; ANT-DBS was linked with a 41% seizure frequency reduction at 1 year, 69% at 5 years, and 75% at 7 years. The most frequently reported adverse effects, depression and memory impairment, were considered non -serious in the long-term follow-up view. ANT-DBS also has been used in a few cases to treat status epilep-ticus. Conclusions: We reviewed the clinical literature and identified several factors that may predict seizure outcome following DBS therapy. More large-scale trials are required since there is a need to explore stim-ulation settings, apply patient-tailored therapy, and identify the presurgical predictors of patient response. Significance: A critical review of the published literature on ANT-DBS in focal epilepsy is presented. ANT-DBS mechanisms are not fully understood; possible explanations are provided. Biomarkers of ANT-DBS effectiveness may lead to patient-tailored therapy.
ER  -

DEUTSCHOVÁ, Barbora and Ivan REKTOR. Deep brain stimulation of the anterior nuclei of the thalamus in focal epilepsy. \textit{Clinical Neurophysiology}. Clare: Elsevier Ireland, 2022, vol.~144, December 2022, p.~1-7. ISSN~1388-2457. Available from: https://dx.doi.org/10.1016/j.clinph.2022.09.002.

Detailed Information on Publication Record