Immune system disorders in the early post-injury period in
patients after severe brain injury from the perspective of the
severity of the injury

J 2023

Immune system disorders in the early post-injury period in patients after severe brain injury from the perspective of the severity of the injury

MRLIAN, Andrej, Martin SMRČKA, Vilém JURÁŇ, Ondřej NAVRÁTIL, Eduard NEUMAN et. al.

Basic information

Original name

Immune system disorders in the early post-injury period in patients after severe brain injury from the perspective of the severity of the injury

Authors

MRLIAN, Andrej (703 Slovakia, guarantor, belonging to the institution), Martin SMRČKA (203 Czech Republic, belonging to the institution), Vilém JURÁŇ (203 Czech Republic, belonging to the institution), Ondřej NAVRÁTIL (203 Czech Republic, belonging to the institution), Eduard NEUMAN (203 Czech Republic, belonging to the institution) and Kamil ĎURIŠ (203 Czech Republic, belonging to the institution)

Edition

NEUROLOGICAL SCIENCES, Milan, Springer, 2023, 1590-1874

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30210 Clinical neurology

Country of publisher

Italy

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 3.300 in 2022

RIV identification code

RIV/00216224:14110/23:00130201

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.1007/s10072-022-06482-1

UT WoS

000881545900001

Keywords in English

Brain trauma; Immune system disorders

Abstract

V originále

Background Brain injuries are the most common cause of death in productive age. Besides the extent of the injury, other systemic factors can also affect the outcome. Patients suffering from severe brain injury often experience extracranial inflammatory complications during the early period of treatment. Here, we investigate the changes in immunity in patients with brain injury. Methods 121 patients and 92 healthy controls were included in the research. Blood samples were collected on admission and analyzed by flow cytometry and biochemical methods. Multiple clusters of differentiation (CD) and antibody levels were investigated. The results were compared between patients and controls. In addition, results of two classes of severity (Glasgow Coma Scale, GCS, of 3-5 vs. 6-8) were also compared. Results Parameters of humoral immunity in patients immediately after admission were significantly lower than those from healthy donors, with the exception of IgE elevated as much as to resemble allergic reaction (p < 0.01). Of cellular parameters, only natural killer (NK) cluster CD56 + was elevated (p < 0.01). Extracranial infectious complications were more common in patients with GCS 3-5. Conclusions Strong immune system disorders were observed in patients after severe brain injury, which may contribute to the worse outcome in such patients.

Citovat

MRLIAN, Andrej, Martin SMRČKA, Vilém JURÁŇ, Ondřej NAVRÁTIL, Eduard NEUMAN and Kamil ĎURIŠ. Immune system disorders in the early post-injury period in patients after severe brain injury from the perspective of the severity of the injury. NEUROLOGICAL SCIENCES. Milan: Springer, 2023, vol. 44, No 3, p. 1031-1038. ISSN 1590-1874. Available from: https://dx.doi.org/10.1007/s10072-022-06482-1.

@article{2248011,
   author = {Mrlian, Andrej and Smrčka, Martin and Juráň, Vilém and Navrátil, Ondřej and Neuman, Eduard and Ďuriš, Kamil},
   article_location = {Milan},
   article_number = {3},
   doi = {http://dx.doi.org/10.1007/s10072-022-06482-1},
   keywords = {Brain trauma; Immune system disorders},
   language = {eng},
   issn = {1590-1874},
   journal = {NEUROLOGICAL SCIENCES},
   title = {Immune system disorders in the early post-injury period in patients after severe brain injury from the perspective of the severity of the injury},
   url = {https://link.springer.com/article/10.1007/s10072-022-06482-1},
   volume = {44},
   year = {2023}
}

TY  - JOUR
ID  - 2248011
AU  - Mrlian, Andrej - Smrčka, Martin - Juráň, Vilém - Navrátil, Ondřej - Neuman, Eduard - Ďuriš, Kamil
PY  - 2023
TI  - Immune system disorders in the early post-injury period in patients after severe brain injury from the perspective of the severity of the injury
JF  - NEUROLOGICAL SCIENCES
VL  - 44
IS  - 3
SP  - 1031-1038
EP  - 1031-1038
PB  - Springer
SN  - 15901874
KW  - Brain trauma
KW  - Immune system disorders
UR  - https://link.springer.com/article/10.1007/s10072-022-06482-1
N2  - Background Brain injuries are the most common cause of death in productive age. Besides the extent of the injury, other systemic factors can also affect the outcome. Patients suffering from severe brain injury often experience extracranial inflammatory complications during the early period of treatment. Here, we investigate the changes in immunity in patients with brain injury. Methods 121 patients and 92 healthy controls were included in the research. Blood samples were collected on admission and analyzed by flow cytometry and biochemical methods. Multiple clusters of differentiation (CD) and antibody levels were investigated. The results were compared between patients and controls. In addition, results of two classes of severity (Glasgow Coma Scale, GCS, of 3-5 vs. 6-8) were also compared. Results Parameters of humoral immunity in patients immediately after admission were significantly lower than those from healthy donors, with the exception of IgE elevated as much as to resemble allergic reaction (p < 0.01). Of cellular parameters, only natural killer (NK) cluster CD56 + was elevated (p < 0.01). Extracranial infectious complications were more common in patients with GCS 3-5. Conclusions Strong immune system disorders were observed in patients after severe brain injury, which may contribute to the worse outcome in such patients.
ER  -

MRLIAN, Andrej, Martin SMRČKA, Vilém JURÁŇ, Ondřej NAVRÁTIL, Eduard NEUMAN and Kamil ĎURIŠ. Immune system disorders in the early post-injury period in patients after severe brain injury from the perspective of the severity of the injury. \textit{NEUROLOGICAL SCIENCES}. Milan: Springer, 2023, vol.~44, No~3, p.~1031-1038. ISSN~1590-1874. Available from: https://dx.doi.org/10.1007/s10072-022-06482-1.

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