Polymorphism rs7079 in miR-31/-584 Binding Site in
Angiotensinogen Gene Associates with Earlier Onset of Coronary
Artery Disease in Central European Population

J 2022

Polymorphism rs7079 in miR-31/-584 Binding Site in Angiotensinogen Gene Associates with Earlier Onset of Coronary Artery Disease in Central European Population

NOVÁK, Jan, Soňa MACEKOVÁ, Renata HÉŽOVÁ, Jan MÁCHAL, Filip ZLÁMAL et. al.

Basic information

Original name

Polymorphism rs7079 in miR-31/-584 Binding Site in Angiotensinogen Gene Associates with Earlier Onset of Coronary Artery Disease in Central European Population

Authors

NOVÁK, Jan (203 Czech Republic, guarantor, belonging to the institution), Soňa MACEKOVÁ (703 Slovakia, belonging to the institution), Renata HÉŽOVÁ (203 Czech Republic, belonging to the institution), Jan MÁCHAL (203 Czech Republic, belonging to the institution), Filip ZLÁMAL (203 Czech Republic, belonging to the institution), Ota HLINOMAZ (203 Czech Republic, belonging to the institution), Michal REZEK (203 Czech Republic, belonging to the institution), Miroslav SOUČEK (203 Czech Republic, belonging to the institution), Anna VAŠKŮ (203 Czech Republic, belonging to the institution), Ondřej SLABÝ (203 Czech Republic, belonging to the institution) and Julie DOBROVOLNÁ (203 Czech Republic, belonging to the institution)

Edition

Genes, BASEL, MDPI, 2022, 2073-4425

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30201 Cardiac and Cardiovascular systems

Country of publisher

Switzerland

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 3.500

RIV identification code

RIV/00216224:14110/22:00128159

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.3390/genes13111981

UT WoS

000881251800001

Keywords in English

rs7079; angiotensinogen; restenosis; age; coronary artery disease

Abstract

V originále

Angiotensinogen (AGT) represents a key component of the renin-angiotensin-aldosterone system (RAAS). Polymorphisms in the 3' untranslated region (3'UTR) of the AGT gene may alter miRNA binding and cause disbalance in the RAAS. Within this study, we evaluated the possible association of AGT +11525C/A (rs7079) with the clinical characteristics of patients with coronary artery diseases (CAD). Selective coronarography was performed in 652 consecutive CAD patients. Clinical characteristics of the patients, together with peripheral blood samples for DNA isolation, were collected. The genotyping of rs7079 polymorphism was performed with TaqMan (R) SNP Genotyping Assays. We observed that patients with the CC genotype were referred for coronarography at a younger age compared to those with the AA+CA genotypes (CC vs. AA+CA: 59.1 +/- 9.64 vs. 60.91 +/- 9.5 (years), p = 0.045). Moreover, according to the logistic regression model, patients with the CC genotype presented more often with restenosis than those with the CA genotype (p = 0.0081). In conclusion, CC homozygotes for rs7079 present with CAD symptoms at a younger age compared with those with the AA+CA genotype, and they are more prone to present with restenosis compared with heterozygotes.

Links

MUNI/A/1156/2021, interní kód MU

Name: Diferenciální diagnostika a odhad prognózy vnitřních nemocí 5 (Acronym: DIDIPRON 5)

Investor: Masaryk University

Citovat

NOVÁK, Jan, Soňa MACEKOVÁ, Renata HÉŽOVÁ, Jan MÁCHAL, Filip ZLÁMAL, Ota HLINOMAZ, Michal REZEK, Miroslav SOUČEK, Anna VAŠKŮ, Ondřej SLABÝ and Julie DOBROVOLNÁ. Polymorphism rs7079 in miR-31/-584 Binding Site in Angiotensinogen Gene Associates with Earlier Onset of Coronary Artery Disease in Central European Population. Genes. BASEL: MDPI, 2022, vol. 13, No 11, p. 1-9. ISSN 2073-4425. Available from: https://dx.doi.org/10.3390/genes13111981.

@article{2248017,
   author = {Novák, Jan and Maceková, Soňa and Héžová, Renata and Máchal, Jan and Zlámal, Filip and Hlinomaz, Ota and Rezek, Michal and Souček, Miroslav and Vašků, Anna and Slabý, Ondřej and Dobrovolná, Julie},
   article_location = {BASEL},
   article_number = {11},
   doi = {http://dx.doi.org/10.3390/genes13111981},
   keywords = {rs7079; angiotensinogen; restenosis; age; coronary artery disease},
   language = {eng},
   issn = {2073-4425},
   journal = {Genes},
   title = {Polymorphism rs7079 in miR-31/-584 Binding Site in Angiotensinogen Gene Associates with Earlier Onset of Coronary Artery Disease in Central European Population},
   url = {https://www.mdpi.com/2073-4425/13/11/1981},
   volume = {13},
   year = {2022}
}

TY  - JOUR
ID  - 2248017
AU  - Novák, Jan - Maceková, Soňa - Héžová, Renata - Máchal, Jan - Zlámal, Filip - Hlinomaz, Ota - Rezek, Michal - Souček, Miroslav - Vašků, Anna - Slabý, Ondřej - Dobrovolná, Julie
PY  - 2022
TI  - Polymorphism rs7079 in miR-31/-584 Binding Site in Angiotensinogen Gene Associates with Earlier Onset of Coronary Artery Disease in Central European Population
JF  - Genes
VL  - 13
IS  - 11
SP  - 1-9
EP  - 1-9
PB  - MDPI
SN  - 20734425
KW  - rs7079
KW  - angiotensinogen
KW  - restenosis
KW  - age
KW  - coronary artery disease
UR  - https://www.mdpi.com/2073-4425/13/11/1981
N2  - Angiotensinogen (AGT) represents a key component of the renin-angiotensin-aldosterone system (RAAS). Polymorphisms in the 3' untranslated region (3'UTR) of the AGT gene may alter miRNA binding and cause disbalance in the RAAS. Within this study, we evaluated the possible association of AGT +11525C/A (rs7079) with the clinical characteristics of patients with coronary artery diseases (CAD). Selective coronarography was performed in 652 consecutive CAD patients. Clinical characteristics of the patients, together with peripheral blood samples for DNA isolation, were collected. The genotyping of rs7079 polymorphism was performed with TaqMan (R) SNP Genotyping Assays. We observed that patients with the CC genotype were referred for coronarography at a younger age compared to those with the AA+CA genotypes (CC vs. AA+CA: 59.1 +/- 9.64 vs. 60.91 +/- 9.5 (years), p = 0.045). Moreover, according to the logistic regression model, patients with the CC genotype presented more often with restenosis than those with the CA genotype (p = 0.0081). In conclusion, CC homozygotes for rs7079 present with CAD symptoms at a younger age compared with those with the AA+CA genotype, and they are more prone to present with restenosis compared with heterozygotes.
ER  -

NOVÁK, Jan, Soňa MACEKOVÁ, Renata HÉŽOVÁ, Jan MÁCHAL, Filip ZLÁMAL, Ota HLINOMAZ, Michal REZEK, Miroslav SOUČEK, Anna VAŠKŮ, Ondřej SLABÝ and Julie DOBROVOLNÁ. Polymorphism rs7079 in miR-31/-584 Binding Site in Angiotensinogen Gene Associates with Earlier Onset of Coronary Artery Disease in Central European Population. \textit{Genes}. BASEL: MDPI, 2022, vol.~13, No~11, p.~1-9. ISSN~2073-4425. Available from: https://dx.doi.org/10.3390/genes13111981.

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