Polymorphism rs7079 in miR-31/-584 Binding Site in Angiotensinogen Gene Associates with Earlier Onset of Coronary Artery Disease in Central European Population

NOVÁK, Jan, Soňa MACEKOVÁ, Renata HÉŽOVÁ, Jan MÁCHAL, Filip ZLÁMAL, Ota HLINOMAZ, Michal REZEK, Miroslav SOUČEK, Anna VAŠKŮ, Ondřej SLABÝ and Julie DOBROVOLNÁ. Polymorphism rs7079 in miR-31/-584 Binding Site in Angiotensinogen Gene Associates with Earlier Onset of Coronary Artery Disease in Central European Population. Genes. BASEL: MDPI, 2022, vol. 13, No 11, p. 1-9. ISSN 2073-4425. Available from: https://dx.doi.org/10.3390/genes13111981.

Basic information

• Original name: Polymorphism rs7079 in miR-31/-584 Binding Site in Angiotensinogen Gene Associates with Earlier Onset of Coronary Artery Disease in Central European Population
• Authors: NOVÁK, Jan (203 Czech Republic, guarantor, belonging to the institution), Soňa MACEKOVÁ (703 Slovakia, belonging to the institution), Renata HÉŽOVÁ (203 Czech Republic, belonging to the institution), Jan MÁCHAL (203 Czech Republic, belonging to the institution), Filip ZLÁMAL (203 Czech Republic, belonging to the institution), Ota HLINOMAZ (203 Czech Republic, belonging to the institution), Michal REZEK (203 Czech Republic, belonging to the institution), Miroslav SOUČEK (203 Czech Republic, belonging to the institution), Anna VAŠKŮ (203 Czech Republic, belonging to the institution), Ondřej SLABÝ (203 Czech Republic, belonging to the institution) and Julie DOBROVOLNÁ (203 Czech Republic, belonging to the institution).
• Edition: Genes, BASEL, MDPI, 2022, 2073-4425.

Other information

• Original language: English
• Type of outcome: Article in a journal
• Field of Study: 30201 Cardiac and Cardiovascular systems
• Country of publisher: Switzerland
• Confidentiality degree: is not subject to a state or trade secret
• WWW: URL
• Impact factor: Impact factor: 3.500
• RIV identification code: RIV/00216224:14110/22:00128159
• Organization unit: Faculty of Medicine
• Doi: http://dx.doi.org/10.3390/genes13111981
• UT WoS: 000881251800001
• Keywords in English: rs7079; angiotensinogen; restenosis; age; coronary artery disease
• Tags: 14110115, 14110116, 14110513, 14110515, 14110518, podil, rivok
• Tags: International impact, Reviewed

Abstract

Angiotensinogen (AGT) represents a key component of the renin-angiotensin-aldosterone system (RAAS). Polymorphisms in the 3' untranslated region (3'UTR) of the AGT gene may alter miRNA binding and cause disbalance in the RAAS. Within this study, we evaluated the possible association of AGT +11525C/A (rs7079) with the clinical characteristics of patients with coronary artery diseases (CAD). Selective coronarography was performed in 652 consecutive CAD patients. Clinical characteristics of the patients, together with peripheral blood samples for DNA isolation, were collected. The genotyping of rs7079 polymorphism was performed with TaqMan (R) SNP Genotyping Assays. We observed that patients with the CC genotype were referred for coronarography at a younger age compared to those with the AA+CA genotypes (CC vs. AA+CA: 59.1 +/- 9.64 vs. 60.91 +/- 9.5 (years), p = 0.045). Moreover, according to the logistic regression model, patients with the CC genotype presented more often with restenosis than those with the CA genotype (p = 0.0081). In conclusion, CC homozygotes for rs7079 present with CAD symptoms at a younger age compared with those with the AA+CA genotype, and they are more prone to present with restenosis compared with heterozygotes.

Links

• MUNI/A/1156/2021, interní kód MU: Name: Diferenciální diagnostika a odhad prognózy vnitřních nemocí 5 (Acronym: DIDIPRON 5)

Investor: Masaryk University