J 2022

Onemocnění asociované s imunoglobulinem IgG4. Klinické příznaky, diferenciální diagnostika a recentní mezinárodní diagnostická kritéria

ADAM, Zdeněk, David ZEMAN, Aleš ČERMÁK, Milan DASTYCH, Martina DOUBKOVÁ et. al.

Basic information

Original name

Onemocnění asociované s imunoglobulinem IgG4. Klinické příznaky, diferenciální diagnostika a recentní mezinárodní diagnostická kritéria

Name (in English)

IgG4-related disease. Clinical manifestation differential diagnosis and recent International Diagnostic Criteria for IgG4-related disease

Authors

ADAM, Zdeněk (203 Czech Republic, guarantor, belonging to the institution), David ZEMAN (203 Czech Republic), Aleš ČERMÁK (203 Czech Republic, belonging to the institution), Milan DASTYCH (203 Czech Republic, belonging to the institution), Martina DOUBKOVÁ (203 Czech Republic, belonging to the institution), Teodor HORVÁTH (203 Czech Republic, belonging to the institution), Šárka SKORKOVSKÁ (203 Czech Republic, belonging to the institution), Zuzana ADAMOVÁ (203 Czech Republic), Zdeněk ŘEHÁK (203 Czech Republic), Renata KOUKALOVÁ (203 Czech Republic), Luděk POUR (203 Czech Republic, belonging to the institution), Martin ŠTORK (203 Czech Republic, belonging to the institution), Marta KREJČÍ (203 Czech Republic, belonging to the institution), Viera SANDECKÁ (703 Slovakia, belonging to the institution), Sabina ŠEVČÍKOVÁ (203 Czech Republic, belonging to the institution) and Zdeněk KRÁL (203 Czech Republic, belonging to the institution)

Edition

Vnitřní lékařství, Praha, Česká lékařská společnost J. E. Purkyně, 2022, 0042-773X

Other information

Language

Czech

Type of outcome

Článek v odborném periodiku

Field of Study

30203 Respiratory systems

Country of publisher

Czech Republic

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

RIV identification code

RIV/00216224:14110/22:00128166

Organization unit

Faculty of Medicine

Keywords (in Czech)

IgG4 immunoglobulin subclass; IgG4 related disease

Keywords in English

IgG4 immunoglobulin subclass; IgG4 related disease

Tags

Tags

Reviewed
Změněno: 8/2/2023 14:41, Mgr. Tereza Miškechová

Abstract

V originále

Immunoglobulin G4-related disease (IgG4-RD) is a rare systemic fibro-inflammatory disorder. Autoimmune pancreatitis is the most frequent manifestation of IgG4-RD. However, IgG4-RD can affect any organ such as salivary glands, orbits, retroperito-neum, prostate and many others. Recent research enabled a clear clinical and histopathological description of IgG4-RD and in 2019 four Clinical phenotypes of IgG4-related disease were described. Diagnosis is based on morphological examination with typical findings of lymphoplasmocellular inflammation, storiform fibrosis and obliterative phlebitis in IgG4-RD biopsies and the tissue invading plasma cells largely produce IgG4. Elevated serum IgG4 levels are found in many but not all patients. New diagnostic criteria for IgG4-RD have been published recently in 2019 and 2021. This review summarizes current knowledge on pathophysiology, clinical manifestations, diagnosis and differential diagnosis of IgG4-RD from the point of view 2022 and in next article brings overview of the IgG4-RD therapy. © 2022, SOLEN s.r.o.. All rights reserved.

In English

Immunoglobulin G4-related disease (IgG4-RD) is a rare systemic fibro-inflammatory disorder. Autoimmune pancreatitis is the most frequent manifestation of IgG4-RD. However, IgG4-RD can affect any organ such as salivary glands, orbits, retroperito-neum, prostate and many others. Recent research enabled a clear clinical and histopathological description of IgG4-RD and in 2019 four Clinical phenotypes of IgG4-related disease were described. Diagnosis is based on morphological examination with typical findings of lymphoplasmocellular inflammation, storiform fibrosis and obliterative phlebitis in IgG4-RD biopsies and the tissue invading plasma cells largely produce IgG4. Elevated serum IgG4 levels are found in many but not all patients. New diagnostic criteria for IgG4-RD have been published recently in 2019 and 2021. This review summarizes current knowledge on pathophysiology, clinical manifestations, diagnosis and differential diagnosis of IgG4-RD from the point of view 2022 and in next article brings overview of the IgG4-RD therapy. © 2022, SOLEN s.r.o.. All rights reserved.