Signaling pathways in cutaneous wound healing

KRIŽANOVÁ, Oľga, Adela PENESOVA, Jozef SOKOL, Alica HOKYNKOVÁ, Amir SAMADIAN and Petr BABULA. Signaling pathways in cutaneous wound healing. Frontiers in Physiology. Lausanne: FRONTIERS MEDIA SA, 2022, vol. 13, November 2022, p. 1-11. ISSN 1664-042X. Available from: https://dx.doi.org/10.3389/fphys.2022.1030851.

Basic information

• Original name: Signaling pathways in cutaneous wound healing
• Authors: KRIŽANOVÁ, Oľga (703 Slovakia, belonging to the institution), Adela PENESOVA, Jozef SOKOL, Alica HOKYNKOVÁ (703 Slovakia, belonging to the institution), Amir SAMADIAN (364 Islamic Republic of Iran, belonging to the institution) and Petr BABULA (203 Czech Republic, guarantor, belonging to the institution).
• Edition: Frontiers in Physiology, Lausanne, FRONTIERS MEDIA SA, 2022, 1664-042X.

Other information

• Original language: English
• Type of outcome: Article in a journal
• Field of Study: 30105 Physiology
• Country of publisher: Switzerland
• Confidentiality degree: is not subject to a state or trade secret
• WWW: URL
• Impact factor: Impact factor: 4.000
• RIV identification code: RIV/00216224:14110/22:00129728
• Organization unit: Faculty of Medicine
• Doi: http://dx.doi.org/10.3389/fphys.2022.1030851
• UT WoS: 000895789500001
• Keywords in English: wound healing; gasotransmitters; calcium; hydrogen peroxide; diabetes mellitus
• Tags: 14110229, 14110515, rivok
• Tags: International impact, Reviewed

Abstract

Wound healing is a very complex process, where variety of different pathways is activated, depending on the phase of healing. Improper or interrupted healing might result in development of chronic wounds. Therefore, novel approaches based on detailed knowledge of signalling pathways that are activated during acute or chronic cutaneous wound healing enables quicker and more effective healing. This review outlined new possibilities of cutaneous wound healing by modulation of some signalling molecules, e.g., gasotransmitters, or calcium. Special focus is given to gasotransmitters, since these bioactive signalling molecules that can freely diffuse into the cell and exert antioxidative effects. Calcium is an important booster of immune system and it can significantly contribute to healing process. Special interest is given to chronic wounds caused by diabetes mellitus and overcoming problems with the inflammation.

Links

• NU21-09-00541, research and development project: Name: Role oxidativního stresu při hojení dekubitů u pacientů s míšní lézí

Investor: Ministry of Health of the CR, Subprogram 1 - standard