SLONKOVÁ, Veronika, Anna VAŠKŮ and Vladimír VAŠKŮ. Polymorphisms in some proinflammatory genes (TNF alpha and beta, IL-1 beta, IL-6, ADAM17) in severe chronic venous disease. JEADV - journal of the European Academy of Dermatology and Venereology. England: BLACKWELL PUBLISHING, 2023, vol. 37, No 3, p. 590-597. ISSN 0926-9959. Available from: https://dx.doi.org/10.1111/jdv.18770.
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Basic information
Original name Polymorphisms in some proinflammatory genes (TNF alpha and beta, IL-1 beta, IL-6, ADAM17) in severe chronic venous disease
Authors SLONKOVÁ, Veronika (203 Czech Republic, belonging to the institution), Anna VAŠKŮ (203 Czech Republic, guarantor, belonging to the institution) and Vladimír VAŠKŮ (203 Czech Republic, belonging to the institution).
Edition JEADV - journal of the European Academy of Dermatology and Venereology, England, BLACKWELL PUBLISHING, 2023, 0926-9959.
Other information
Original language English
Type of outcome Article in a journal
Field of Study 30216 Dermatology and venereal diseases
Country of publisher United States of America
Confidentiality degree is not subject to a state or trade secret
WWW URL
Impact factor Impact factor: 9.200 in 2022
RIV identification code RIV/00216224:14110/23:00130206
Organization unit Faculty of Medicine
Doi http://dx.doi.org/10.1111/jdv.18770
UT WoS 000897650900001
Keywords in English polymorphisms; proinflammatory genes; severe chronic venous disease
Tags 14110125, 14110518, rivok
Tags International impact, Reviewed
Changed by Changed by: Mgr. Tereza Miškechová, učo 341652. Changed: 26/1/2024 10:39.
Abstract
BackgroundChronic venous disease (CVD) is a common disorder of lower extremities. ObjectivesThe study was scheduled to investigate the relationship between polymorphisms in major proinflammatory genes TNF alpha (-238 A/G; -308 A/G), TNF beta (NcoI), IL-1 beta (+3953 T/C); IL-6 (-174 G/C; -596 G/C) and ADAM17 (3 ' TACE) and CVD risk. Genotype-phenotype study was calculated to test possible association between examined genotypes and phenotypes of CVD. MethodsFinally, 150 CVD patients and 227 control subjects were enrolled to the study.Genotypes in proinflammatory gene polymorphisms were identified from isolated DNA by PCR method and restriction analysis. ResultsSignificant differences in genotype distribution/allelic frequencies in TNF beta gene, IL-1 beta gene and in ADAM17 gene polymorphisms were found between CVD women and control ones. In the genotype-phenotype study, identified genotypes were associated with arterial hypertension (ADAM17, IL-6-men), ischaemic heart disease (TNF alpha and beta genes), diabetes mellitus (ADAM17-women, TNF beta-men), age of CVD onset (TNF alpha and IL-6), ulceration (ADAM17), duration of ulceration (ADAM17), ulceration recurrence (ADAM17-women), home care necessity (TNF alpha), varices surgery (TNF alpha), erysipelas development (ADAM17-men) and tumour development (TNF alpha). ConclusionStudying of these polymorphisms associations can help us better identify patients at higher risk of developing severe CVD.
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