J 2023

Polymorphisms in some proinflammatory genes (TNF alpha and beta, IL-1 beta, IL-6, ADAM17) in severe chronic venous disease

SLONKOVÁ, Veronika, Anna VAŠKŮ and Vladimír VAŠKŮ

Basic information

Original name

Polymorphisms in some proinflammatory genes (TNF alpha and beta, IL-1 beta, IL-6, ADAM17) in severe chronic venous disease

Authors

SLONKOVÁ, Veronika (203 Czech Republic, belonging to the institution), Anna VAŠKŮ (203 Czech Republic, guarantor, belonging to the institution) and Vladimír VAŠKŮ (203 Czech Republic, belonging to the institution)

Edition

JEADV - journal of the European Academy of Dermatology and Venereology, England, BLACKWELL PUBLISHING, 2023, 0926-9959

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30216 Dermatology and venereal diseases

Country of publisher

United States of America

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

Impact factor

Impact factor: 9.200 in 2022

RIV identification code

RIV/00216224:14110/23:00130206

Organization unit

Faculty of Medicine

DOI

UT WoS

000897650900001

Keywords in English

polymorphisms; proinflammatory genes; severe chronic venous disease

Tags

Tags

International impact, Reviewed
Změněno: 26/1/2024 10:39, Mgr. Tereza Miškechová

Abstract

V originále

BackgroundChronic venous disease (CVD) is a common disorder of lower extremities. ObjectivesThe study was scheduled to investigate the relationship between polymorphisms in major proinflammatory genes TNF alpha (-238 A/G; -308 A/G), TNF beta (NcoI), IL-1 beta (+3953 T/C); IL-6 (-174 G/C; -596 G/C) and ADAM17 (3 ' TACE) and CVD risk. Genotype-phenotype study was calculated to test possible association between examined genotypes and phenotypes of CVD. MethodsFinally, 150 CVD patients and 227 control subjects were enrolled to the study.Genotypes in proinflammatory gene polymorphisms were identified from isolated DNA by PCR method and restriction analysis. ResultsSignificant differences in genotype distribution/allelic frequencies in TNF beta gene, IL-1 beta gene and in ADAM17 gene polymorphisms were found between CVD women and control ones. In the genotype-phenotype study, identified genotypes were associated with arterial hypertension (ADAM17, IL-6-men), ischaemic heart disease (TNF alpha and beta genes), diabetes mellitus (ADAM17-women, TNF beta-men), age of CVD onset (TNF alpha and IL-6), ulceration (ADAM17), duration of ulceration (ADAM17), ulceration recurrence (ADAM17-women), home care necessity (TNF alpha), varices surgery (TNF alpha), erysipelas development (ADAM17-men) and tumour development (TNF alpha). ConclusionStudying of these polymorphisms associations can help us better identify patients at higher risk of developing severe CVD.