Long-term home parenteral nutrition and profile of amino acids
in serum and their loss in urine

J 2023

Long-term home parenteral nutrition and profile of amino acids in serum and their loss in urine

DASTYCH, Milan, Michal ŠENKYŘÍK, Alena MIKUŠKOVÁ and Milan DASTYCH

Basic information

Original name

Long-term home parenteral nutrition and profile of amino acids in serum and their loss in urine

Authors

DASTYCH, Milan (203 Czech Republic, belonging to the institution), Michal ŠENKYŘÍK (203 Czech Republic, belonging to the institution), Alena MIKUŠKOVÁ (203 Czech Republic) and Milan DASTYCH (203 Czech Republic, guarantor, belonging to the institution)

Edition

British Journal of Nutrition, CAMBRIDGE, Cambridge University Press, 2023, 0007-1145

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30308 Nutrition, Dietetics

Country of publisher

United Kingdom of Great Britain and Northern Ireland

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 3.600 in 2022

RIV identification code

RIV/00216224:14110/23:00130207

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.1017/S0007114522002008

UT WoS

000850370000001

Keywords in English

Home parenteral nutrition; Essential amino acids; Ion exchange chromatography; Quality of life

Abstract

V originále

Amino acids are an essential part of parenteral nutrition. This study aimed to determine the serum profile of amino acids and their loss in urine in patients with long-term home parenteral nutrition (HPN) during 12 h of infusion in comparison with similar parameters in the remaining 12 has well as in healthy participants. We enrolled forty-five patients with long-term HPN for 6-75 (median, 33) months. The indication for HPN was short bowel syndrome secondary to radical resection of the small intestine following complications of Crohn's disease. HPN was administered via two-chamber all-in-one bags prepared in a hospital pharmacy overnight for 12 h each day. The average dose of amino acids, carbohydrates and fats administered was 1.5, 3.4 and 0.68 g/kg per d, respectively, at an infusion rate of 0.11, 0.28 and 0.06 g/kg per h, respectively. The levels of essential amino acids in the serum of the patients were not significantly different from those in healthy individuals; however, of the non-essential amino acids, cystine and glutamine levels were lower and glycine and ornithine levels were higher in the patients (P < 0.05). Excretion of amino acids in the urine during 12 h of infusion at an infusion rate of 0.11 g/kg per h was 301 mg, while it was 104 mg during the remaining 12 h (P < 0.0001). Our patients on long-term HPN had a normal serum profile of essential amino acids. The total urinary excretion of amino acids during 12 h of infusion accounted for only 0.34 % (0-23-0.46) of the administered dose.

Citovat

DASTYCH, Milan, Michal ŠENKYŘÍK, Alena MIKUŠKOVÁ and Milan DASTYCH. Long-term home parenteral nutrition and profile of amino acids in serum and their loss in urine. British Journal of Nutrition. CAMBRIDGE: Cambridge University Press, 2023, vol. 129, No 9, p. 1537-1542. ISSN 0007-1145. Available from: https://dx.doi.org/10.1017/S0007114522002008.

@article{2248076,
   author = {Dastych, Milan and Šenkyřík, Michal and Mikušková, Alena and Dastych, Milan},
   article_location = {CAMBRIDGE},
   article_number = {9},
   doi = {http://dx.doi.org/10.1017/S0007114522002008},
   keywords = {Home parenteral nutrition; Essential amino acids; Ion exchange chromatography; Quality of life},
   language = {eng},
   issn = {0007-1145},
   journal = {British Journal of Nutrition},
   title = {Long-term home parenteral nutrition and profile of amino acids in serum and their loss in urine},
   url = {https://www.cambridge.org/core/journals/british-journal-of-nutrition/article/longterm-home-parenteral-nutrition-and-profile-of-amino-acids-in-serum-and-their-loss-in-urine/F9AE53803D7AA9C4D5C24F1314EE51BF},
   volume = {129},
   year = {2023}
}

TY  - JOUR
ID  - 2248076
AU  - Dastych, Milan - Šenkyřík, Michal - Mikušková, Alena - Dastych, Milan
PY  - 2023
TI  - Long-term home parenteral nutrition and profile of amino acids in serum and their loss in urine
JF  - British Journal of Nutrition
VL  - 129
IS  - 9
SP  - 1537-1542
EP  - 1537-1542
PB  - Cambridge University Press
SN  - 00071145
KW  - Home parenteral nutrition
KW  - Essential amino acids
KW  - Ion exchange chromatography
KW  - Quality of life
UR  - https://www.cambridge.org/core/journals/british-journal-of-nutrition/article/longterm-home-parenteral-nutrition-and-profile-of-amino-acids-in-serum-and-their-loss-in-urine/F9AE53803D7AA9C4D5C24F1314EE51BF
N2  - Amino acids are an essential part of parenteral nutrition. This study aimed to determine the serum profile of amino acids and their loss in urine in patients with long-term home parenteral nutrition (HPN) during 12 h of infusion in comparison with similar parameters in the remaining 12 has well as in healthy participants. We enrolled forty-five patients with long-term HPN for 6-75 (median, 33) months. The indication for HPN was short bowel syndrome secondary to radical resection of the small intestine following complications of Crohn's disease. HPN was administered via two-chamber all-in-one bags prepared in a hospital pharmacy overnight for 12 h each day. The average dose of amino acids, carbohydrates and fats administered was 1.5, 3.4 and 0.68 g/kg per d, respectively, at an infusion rate of 0.11, 0.28 and 0.06 g/kg per h, respectively. The levels of essential amino acids in the serum of the patients were not significantly different from those in healthy individuals; however, of the non-essential amino acids, cystine and glutamine levels were lower and glycine and ornithine levels were higher in the patients (P < 0.05). Excretion of amino acids in the urine during 12 h of infusion at an infusion rate of 0.11 g/kg per h was 301 mg, while it was 104 mg during the remaining 12 h (P < 0.0001). Our patients on long-term HPN had a normal serum profile of essential amino acids. The total urinary excretion of amino acids during 12 h of infusion accounted for only 0.34 % (0-23-0.46) of the administered dose.
ER  -

DASTYCH, Milan, Michal ŠENKYŘÍK, Alena MIKUŠKOVÁ and Milan DASTYCH. Long-term home parenteral nutrition and profile of amino acids in serum and their loss in urine. \textit{British Journal of Nutrition}. CAMBRIDGE: Cambridge University Press, 2023, vol.~129, No~9, p.~1537-1542. ISSN~0007-1145. Available from: https://dx.doi.org/10.1017/S0007114522002008.

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