Detailed Information on Publication Record
2022
Iron Deficiency in Patients with Advanced Heart Failure
BAKOŠOVÁ, Mária, Jan KREJČÍ, Július GODAVA, Eva OZÁBALOVÁ, Hana POLOCZKOVÁ et. al.Basic information
Original name
Iron Deficiency in Patients with Advanced Heart Failure
Name in Czech
Deficit železa u pacientů s pokročilým srdečním selháním
Authors
BAKOŠOVÁ, Mária (703 Slovakia, belonging to the institution), Jan KREJČÍ (203 Czech Republic, guarantor, belonging to the institution), Július GODAVA (703 Slovakia), Eva OZÁBALOVÁ (203 Czech Republic), Hana POLOCZKOVÁ (203 Czech Republic, belonging to the institution), Tomáš HONEK (203 Czech Republic), Petr HUDE (203 Czech Republic), Jan MÁCHAL (203 Czech Republic, belonging to the institution), Helena BEDÁŇOVÁ (203 Czech Republic), Petr NĚMEC (203 Czech Republic, belonging to the institution) and Lenka ŠPINAROVÁ (203 Czech Republic, belonging to the institution)
Edition
Medicina, Basel, MDPI, 2022, 1010-660X
Other information
Language
English
Type of outcome
Článek v odborném periodiku
Field of Study
30201 Cardiac and Cardiovascular systems
Country of publisher
Switzerland
Confidentiality degree
není předmětem státního či obchodního tajemství
Impact factor
Impact factor: 2.600
RIV identification code
RIV/00216224:14110/22:00128200
Organization unit
Faculty of Medicine
UT WoS
000882105800001
Keywords (in Czech)
deficit železa; pokročilé srdeční selhání; ferritin, saturace transferinu
Keywords in English
iron deficiency; anaemia; advanced heart failure; ferritin; transferrin saturation
Tags
International impact, Reviewed
Změněno: 24/1/2023 13:25, Mgr. Tereza Miškechová
Abstract
V originále
Background and Objectives: Iron deficiency (ID) is a common comorbidity in patients with heart failure. It is associated with reduced physical performance, frequent hospitalisations for heart failure decompensation, and high cardiovascular and overall mortality. The aim was to determine the prevalence of ID in patients with advanced heart failure on the waiting list for heart transplantation. Methods and Materials: We included 52 patients placed on the waiting list for heart transplantation in 2021 at our centre. The cohort included seven patients with LVAD (left ventricle assist device) as a bridge to transplantation implanted before the time of results collection. In addition to standard tests, the parameters of iron metabolism were monitored. ID was defined as a ferritin value <100 mu g/L, or 100-299 mu g/L if transferrin saturation (T-sat) is Results: ID was present in 79% of all subjects, but only in 35% of these patients anaemia was expressed. In the group without LVAD, ID was present in 82%, a median (lower-upper quartile) of ferritin level was 95.4 (62.2-152.1) mu g/mL and mean T-sat was 0.18 +/- 0.09. In LVAD group, ID was present in 57%, ferritin level was 268 (106-368) mu g/mL and mean T-sat was 0.14 +/- 0.04. Haemoglobin concentration was the same in patients with or without ID (133 +/- 16) vs. (133 +/- 23). ID was not associated with anaemia defined with regard to patient's gender. In 40.5% of cases, iron deficiency was accompanied by chronic renal insufficiency, compared to 12.5% of the patients without ID. In the patients with LVAD, ID was present in four out of seven patients, but the group was too small for reliable statistical testing due to low statistical power. Conclusions: ID was present in the majority of patients with advanced heart failure and was not always accompanied by anaemia and renal insufficiency. Research on optimal markers for the diagnosis of iron deficiency, especially for specific groups of patients with heart failure, is still ongoing.
Links
| MUNI/A/1462/2021, interní kód MU |
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