J 2023

Procalcitonin kinetics following abdominal aortic surgery and its value for postoperative intestinal ischaemia detection

NOVOTNÝ, Tomáš, Robert STAFFA, Josef TOMANDL, Tomáš KŘIVKA, Peter KRUŽLIAK et. al.

Basic information

Original name

Procalcitonin kinetics following abdominal aortic surgery and its value for postoperative intestinal ischaemia detection

Authors

NOVOTNÝ, Tomáš (203 Czech Republic, guarantor, belonging to the institution), Robert STAFFA (203 Czech Republic, belonging to the institution), Josef TOMANDL (203 Czech Republic, belonging to the institution), Tomáš KŘIVKA (203 Czech Republic, belonging to the institution), Peter KRUŽLIAK (703 Slovakia, belonging to the institution), Marie TOMANDLOVÁ (203 Czech Republic, belonging to the institution), Ondřej SLABÝ (203 Czech Republic, belonging to the institution), Jan ŠPONIAR (203 Czech Republic, belonging to the institution), Martin CAPRNDA, Ludovit GASPAR, Luis RODRIGO, Ioana MOZOS, Luboš KUBÍČEK (203 Czech Republic, belonging to the institution), Ernest BIROŠ (703 Slovakia, belonging to the institution), Robert VLACHOVSKÝ (203 Czech Republic, belonging to the institution), Lenka RADOVÁ (203 Czech Republic, belonging to the institution) and Anna KONIECZNA (203 Czech Republic, belonging to the institution)

Edition

Vascular, London, Sage Publications Inc, 2023, 1708-5381

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30201 Cardiac and Cardiovascular systems

Country of publisher

United Kingdom of Great Britain and Northern Ireland

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 1.100 in 2022

RIV identification code

RIV/00216224:14110/23:00134622

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.1177/17085381221102812

UT WoS

000805273500001

Keywords in English

Procalcitonin; abdominal aortic aneurysm; aortoiliac occlusive disease; intestinal ischaemia; complications

Tags

14110119, 14110121, 14110512, 14110513, podil, rivok

Tags

International impact, Reviewed
Změněno: 9/12/2024 09:00, Mgr. Tereza Miškechová

Abstract

V originále

Objective The purpose of our study was to describe perioperative kinetics of procalcitonin (PCT) in patients undergoing aortic surgery, to compare the kinetics in the open abdominal aortic aneurysm (AAA) repair and aortobifemoral bypass for aortoiliac occlusive disease (AIOD), and to evaluate the ability of PCT to detect intestinal ischaemia. Methods A prospective non-randomized observational cohort study in 80 patients (62 men and 18 women) undergoing elective aortic surgery was performed. Serum PCT was measured at baseline and defined intraoperative and postoperative timepoints up to postoperative day 7. MRI contrast-enhanced imaging was used to detect intestinal ischaemia. Results The comparison of the AAA and AIOD cohort did not show any significant difference in PCT levels. Patients with intestinal ischaemia had higher serum PCT at multiple timepoints postoperatively. The most accurate timepoints for early diagnosis were postoperative day 3, followed by 24 h after declamping of the vascular reconstruction, and postoperative day 7. The sensitivity and negative predictive values were 100% in all mentioned timepoints. However, event at the best timepoint the specificity was 89% and the positive predictive value 43%. Conclusions Procalcitonin levels in the postoperative period at proper timepoints might help to detect postoperative intestinal ischaemia. The limitation of this marker is its low specificity for intestinal ischaemia and low positive predictive value. The highest value of this marker is that it can rule out this complication because normal PCT levels mean that intestinal ischaemia is very unlikely.

Links

NV17-29701A, research and development project
Name: Ischémií modifikovaný albumin a cirkulující mikroRNA jako nové technologie k monitorování tkáňové ischémie po cévních rekonstrukcích na břišní aortě
Displayed: 24/12/2024 21:54