| NOVOTNÝ, Tomáš, Robert STAFFA, Josef TOMANDL, Tomáš KŘIVKA, Peter KRUŽLIAK, Marie TOMANDLOVÁ, Ondřej SLABÝ, Jan ŠPONIAR, Martin CAPRNDA, Ludovit GASPAR, Luis RODRIGO, Ioana MOZOS, Luboš KUBÍČEK, Ernest BIROS, Robert VLACHOVSKÝ, Lenka RADOVÁ and Anna KONIECZNA. Procalcitonin kinetics following abdominal aortic surgery and its value for postoperative intestinal ischaemia detection. Vascular. London: Sage Publications Inc, 2023, vol. 31, No 6, p. 1061-1068. ISSN 1708-5381. Available from: https://dx.doi.org/10.1177/17085381221102812. |
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@article{2249046,
author = {Novotný, Tomáš and Staffa, Robert and Tomandl, Josef and Křivka, Tomáš and Kružliak, Peter and Tomandlová, Marie and Slabý, Ondřej and Šponiar, Jan and Caprnda, Martin and Gaspar, Ludovit and Rodrigo, Luis and Mozos, Ioana and Kubíček, Luboš and Biros, Ernest and Vlachovský, Robert and Radová, Lenka and Konieczna, Anna},
article_location = {London},
article_number = {6},
doi = {http://dx.doi.org/10.1177/17085381221102812},
keywords = {Procalcitonin; abdominal aortic aneurysm; aortoiliac occlusive disease; intestinal ischaemia; complications},
language = {eng},
issn = {1708-5381},
journal = {Vascular},
title = {Procalcitonin kinetics following abdominal aortic surgery and its value for postoperative intestinal ischaemia detection},
url = {https://journals.sagepub.com/doi/10.1177/17085381221102812},
volume = {31},
year = {2023}
}
TY - JOUR
ID - 2249046
AU - Novotný, Tomáš - Staffa, Robert - Tomandl, Josef - Křivka, Tomáš - Kružliak, Peter - Tomandlová, Marie - Slabý, Ondřej - Šponiar, Jan - Caprnda, Martin - Gaspar, Ludovit - Rodrigo, Luis - Mozos, Ioana - Kubíček, Luboš - Biros, Ernest - Vlachovský, Robert - Radová, Lenka - Konieczna, Anna
PY - 2023
TI - Procalcitonin kinetics following abdominal aortic surgery and its value for postoperative intestinal ischaemia detection
JF - Vascular
VL - 31
IS - 6
SP - 1061-1068
EP - 1061-1068
PB - Sage Publications Inc
SN - 17085381
KW - Procalcitonin
KW - abdominal aortic aneurysm
KW - aortoiliac occlusive disease
KW - intestinal ischaemia
KW - complications
UR - https://journals.sagepub.com/doi/10.1177/17085381221102812
N2 - Objective The purpose of our study was to describe perioperative kinetics of procalcitonin (PCT) in patients undergoing aortic surgery, to compare the kinetics in the open abdominal aortic aneurysm (AAA) repair and aortobifemoral bypass for aortoiliac occlusive disease (AIOD), and to evaluate the ability of PCT to detect intestinal ischaemia. Methods A prospective non-randomized observational cohort study in 80 patients (62 men and 18 women) undergoing elective aortic surgery was performed. Serum PCT was measured at baseline and defined intraoperative and postoperative timepoints up to postoperative day 7. MRI contrast-enhanced imaging was used to detect intestinal ischaemia. Results The comparison of the AAA and AIOD cohort did not show any significant difference in PCT levels. Patients with intestinal ischaemia had higher serum PCT at multiple timepoints postoperatively. The most accurate timepoints for early diagnosis were postoperative day 3, followed by 24 h after declamping of the vascular reconstruction, and postoperative day 7. The sensitivity and negative predictive values were 100% in all mentioned timepoints. However, event at the best timepoint the specificity was 89% and the positive predictive value 43%. Conclusions Procalcitonin levels in the postoperative period at proper timepoints might help to detect postoperative intestinal ischaemia. The limitation of this marker is its low specificity for intestinal ischaemia and low positive predictive value. The highest value of this marker is that it can rule out this complication because normal PCT levels mean that intestinal ischaemia is very unlikely.
ER -
NOVOTNÝ, Tomáš, Robert STAFFA, Josef TOMANDL, Tomáš KŘIVKA, Peter KRUŽLIAK, Marie TOMANDLOVÁ, Ondřej SLABÝ, Jan ŠPONIAR, Martin CAPRNDA, Ludovit GASPAR, Luis RODRIGO, Ioana MOZOS, Luboš KUBÍČEK, Ernest BIROS, Robert VLACHOVSKÝ, Lenka RADOVÁ and Anna KONIECZNA. Procalcitonin kinetics following abdominal aortic surgery and its value for postoperative intestinal ischaemia detection. \textit{Vascular}. London: Sage Publications Inc, 2023, vol.~31, No~6, p.~1061-1068. ISSN~1708-5381. Available from: https://dx.doi.org/10.1177/17085381221102812.
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