Flavonoids exert potential in the management of hypertensive
disorders in pregnancy

J 2022

Flavonoids exert potential in the management of hypertensive disorders in pregnancy

MAZURAKOVA, Alena, Lenka KOKLESOVA, Marek SAMEC, Erik KUDELA, Jana SIVAKOVA et. al.

Basic information

Original name

Flavonoids exert potential in the management of hypertensive disorders in pregnancy

Authors

MAZURAKOVA, Alena, Lenka KOKLESOVA, Marek SAMEC, Erik KUDELA, Jana SIVAKOVA, Terezia PRIBULOVA, Martin Jozef PEC, Martin PEC, Martin KELLO, Dietrich BUSSELBERG, Olga GOLUBNITSCHAJA, Ludovit GASPAR, Martin CAPRNDA, Mariusz ADAMEK, Robert PROSECKÝ (203 Czech Republic, belonging to the institution), Elmira EMINOVA, Denis BARANENKO, Peter KRUŽLIAK (703 Slovakia, guarantor, belonging to the institution), Peter KUBATKA and Kamil BIRINGER

Edition

PREGNANCY HYPERTENSION-AN INTERNATIONAL JOURNAL OF WOMENS CARDIOVASCULAR HEALTH, OXFORD, ELSEVIER SCI LTD, 2022, 2210-7789

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30201 Cardiac and Cardiovascular systems

Country of publisher

United Kingdom of Great Britain and Northern Ireland

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 2.200

RIV identification code

RIV/00216224:14110/22:00128207

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.1016/j.preghy.2022.06.007

UT WoS

000835961500002

Keywords in English

Flavonoids; Hypertensive disorders; Pregnancy; Preeclampsia

Abstract

V originále

Hypertensive disorders in pregnancy represent severe complications of pregnancy, which, if not treated, can result in serious health consequences for the mother and the child. Flavonoids are bioactive secondary metabolites commonly found in fruits, vegetables, green tea, whole grains, and medicinal plants. Flavonoids exert potent protective efficacy in experimental models of hypertensive disorders in pregnancy, especially preeclampsia, demonstrated through their capacity to modulate inflammatory responses, oxidative stress, and vascular dysfunction. In addition to their potential as therapeutics, flavonoids or flavonoid-rich food could be helpful to decrease the risk of hypertensive disorders in pregnancy when included in the diet pattern before and during pregnancy. However, the clinical evaluation of the potential capacity of flavonoids in hypertensive disorders in pregnancy is insufficient. Due to promising results from experimental studies, we highlight the need for the evaluation of flavonoids also in an appropriate clinical setting, which can be, together with proper preventive strategies, helpful in the overall management of hypertensive disorders in pregnancy.

Citovat

MAZURAKOVA, Alena, Lenka KOKLESOVA, Marek SAMEC, Erik KUDELA, Jana SIVAKOVA, Terezia PRIBULOVA, Martin Jozef PEC, Martin PEC, Martin KELLO, Dietrich BUSSELBERG, Olga GOLUBNITSCHAJA, Ludovit GASPAR, Martin CAPRNDA, Mariusz ADAMEK, Robert PROSECKÝ, Elmira EMINOVA, Denis BARANENKO, Peter KRUŽLIAK, Peter KUBATKA and Kamil BIRINGER. Flavonoids exert potential in the management of hypertensive disorders in pregnancy. PREGNANCY HYPERTENSION-AN INTERNATIONAL JOURNAL OF WOMENS CARDIOVASCULAR HEALTH. OXFORD: ELSEVIER SCI LTD, 2022, vol. 29, August 2022, p. 72-85. ISSN 2210-7789. Available from: https://dx.doi.org/10.1016/j.preghy.2022.06.007.

@article{2249048,
   author = {Mazurakova, Alena and Koklesova, Lenka and Samec, Marek and Kudela, Erik and Sivakova, Jana and Pribulova, Terezia and Pec, Martin Jozef and Pec, Martin and Kello, Martin and Busselberg, Dietrich and Golubnitschaja, Olga and Gaspar, Ludovit and Caprnda, Martin and Adamek, Mariusz and Prosecký, Robert and Eminova, Elmira and Baranenko, Denis and Kružliak, Peter and Kubatka, Peter and Biringer, Kamil},
   article_location = {OXFORD},
   article_number = {August 2022},
   doi = {http://dx.doi.org/10.1016/j.preghy.2022.06.007},
   keywords = {Flavonoids; Hypertensive disorders; Pregnancy; Preeclampsia},
   language = {eng},
   issn = {2210-7789},
   journal = {PREGNANCY HYPERTENSION-AN INTERNATIONAL JOURNAL OF WOMENS CARDIOVASCULAR HEALTH},
   title = {Flavonoids exert potential in the management of hypertensive disorders in pregnancy},
   url = {https://www.sciencedirect.com/science/article/pii/S2210778922000642?via%3Dihub},
   volume = {29},
   year = {2022}
}

TY  - JOUR
ID  - 2249048
AU  - Mazurakova, Alena - Koklesova, Lenka - Samec, Marek - Kudela, Erik - Sivakova, Jana - Pribulova, Terezia - Pec, Martin Jozef - Pec, Martin - Kello, Martin - Busselberg, Dietrich - Golubnitschaja, Olga - Gaspar, Ludovit - Caprnda, Martin - Adamek, Mariusz - Prosecký, Robert - Eminova, Elmira - Baranenko, Denis - Kružliak, Peter - Kubatka, Peter - Biringer, Kamil
PY  - 2022
TI  - Flavonoids exert potential in the management of hypertensive disorders in pregnancy
JF  - PREGNANCY HYPERTENSION-AN INTERNATIONAL JOURNAL OF WOMENS CARDIOVASCULAR HEALTH
VL  - 29
IS  - August 2022
SP  - 72-85
EP  - 72-85
PB  - ELSEVIER SCI LTD
SN  - 22107789
KW  - Flavonoids
KW  - Hypertensive disorders
KW  - Pregnancy
KW  - Preeclampsia
UR  - https://www.sciencedirect.com/science/article/pii/S2210778922000642?via%3Dihub
N2  - Hypertensive disorders in pregnancy represent severe complications of pregnancy, which, if not treated, can result in serious health consequences for the mother and the child. Flavonoids are bioactive secondary metabolites commonly found in fruits, vegetables, green tea, whole grains, and medicinal plants. Flavonoids exert potent protective efficacy in experimental models of hypertensive disorders in pregnancy, especially preeclampsia, demonstrated through their capacity to modulate inflammatory responses, oxidative stress, and vascular dysfunction. In addition to their potential as therapeutics, flavonoids or flavonoid-rich food could be helpful to decrease the risk of hypertensive disorders in pregnancy when included in the diet pattern before and during pregnancy. However, the clinical evaluation of the potential capacity of flavonoids in hypertensive disorders in pregnancy is insufficient. Due to promising results from experimental studies, we highlight the need for the evaluation of flavonoids also in an appropriate clinical setting, which can be, together with proper preventive strategies, helpful in the overall management of hypertensive disorders in pregnancy.
ER  -

MAZURAKOVA, Alena, Lenka KOKLESOVA, Marek SAMEC, Erik KUDELA, Jana SIVAKOVA, Terezia PRIBULOVA, Martin Jozef PEC, Martin PEC, Martin KELLO, Dietrich BUSSELBERG, Olga GOLUBNITSCHAJA, Ludovit GASPAR, Martin CAPRNDA, Mariusz ADAMEK, Robert PROSECKÝ, Elmira EMINOVA, Denis BARANENKO, Peter KRUŽLIAK, Peter KUBATKA and Kamil BIRINGER. Flavonoids exert potential in the management of hypertensive disorders in pregnancy. \textit{PREGNANCY HYPERTENSION-AN INTERNATIONAL JOURNAL OF WOMENS CARDIOVASCULAR HEALTH}. OXFORD: ELSEVIER SCI LTD, 2022, vol.~29, August 2022, p.~72-85. ISSN~2210-7789. Available from: https://dx.doi.org/10.1016/j.preghy.2022.06.007.

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