| DAVID, Jan, Veronika STARA, Ondrej HRADSKY, Jana TUČKOVÁ, Kateřina SLABÁ, Petr JABANDŽIEV, Lumir SASEK, Michal HUML, Iveta ZIDKOVA, Jan PAVLICEK, Alzbeta PALATOVA, Eva KLASKOVA, Karina BANSZKA, Eva TERIFAJOVA, Radim VYHNANEK, Marketa BLOOMFIELD, Sarka FINGERHUTOVA, Pavla DOLEZALOVA, Lucie PROCHAZKOVA, Gabriela CHRAMOSTOVA, Filip FENCL and Jan LEBL. Nationwide observational study of paediatric inflammatory multisystem syndrome temporally associated with SARS-CoV-2 (PIMS-TS) in the Czech Republic. European journal of pediatrics. New York: Springer, 2022, vol. 181, No 10, p. 3663-3672. ISSN 0340-6199. Available from: https://dx.doi.org/10.1007/s00431-022-04593-7. |
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@article{2249061,
author = {David, Jan and Stara, Veronika and Hradsky, Ondrej and Tučková, Jana and Slabá, Kateřina and Jabandžiev, Petr and Sasek, Lumir and Huml, Michal and Zidkova, Iveta and Pavlicek, Jan and Palatova, Alzbeta and Klaskova, Eva and Banszka, Karina and Terifajova, Eva and Vyhnanek, Radim and Bloomfield, Marketa and Fingerhutova, Sarka and Dolezalova, Pavla and Prochazkova, Lucie and Chramostova, Gabriela and Fencl, Filip and Lebl, Jan},
article_location = {New York},
article_number = {10},
doi = {http://dx.doi.org/10.1007/s00431-022-04593-7},
keywords = {MIS-C; COVID-19; Incidence; Predictors; Severe outcome; Myocardial dysfunction},
language = {eng},
issn = {0340-6199},
journal = {European journal of pediatrics},
title = {Nationwide observational study of paediatric inflammatory multisystem syndrome temporally associated with SARS-CoV-2 (PIMS-TS) in the Czech Republic},
url = {https://link.springer.com/article/10.1007/s00431-022-04593-7},
volume = {181},
year = {2022}
}
TY - JOUR
ID - 2249061
AU - David, Jan - Stara, Veronika - Hradsky, Ondrej - Tučková, Jana - Slabá, Kateřina - Jabandžiev, Petr - Sasek, Lumir - Huml, Michal - Zidkova, Iveta - Pavlicek, Jan - Palatova, Alzbeta - Klaskova, Eva - Banszka, Karina - Terifajova, Eva - Vyhnanek, Radim - Bloomfield, Marketa - Fingerhutova, Sarka - Dolezalova, Pavla - Prochazkova, Lucie - Chramostova, Gabriela - Fencl, Filip - Lebl, Jan
PY - 2022
TI - Nationwide observational study of paediatric inflammatory multisystem syndrome temporally associated with SARS-CoV-2 (PIMS-TS) in the Czech Republic
JF - European journal of pediatrics
VL - 181
IS - 10
SP - 3663-3672
EP - 3663-3672
PB - Springer
SN - 03406199
KW - MIS-C
KW - COVID-19
KW - Incidence
KW - Predictors
KW - Severe outcome
KW - Myocardial dysfunction
UR - https://link.springer.com/article/10.1007/s00431-022-04593-7
N2 - The worldwide outbreak of the novel 2019 coronavirus disease (COVID-19) has led to recognition of a new immunopathological condition: paediatric inflammatory multisystem syndrome (PIMS-TS). The Czech Republic (CZ) suffered from one of the highest incidences of individuals who tested positive during pandemic waves. The aim of this study was to analyse epidemiological, clinical, and laboratory characteristics of all cases of paediatric inflammatory multisystem syndrome (PIMS-TS) in the Czech Republic (CZ) and their predictors of severe course. We performed a retrospective-prospective nationwide observational study based on patients hospitalised with PIMS-TS in CZ between 1 November 2020 and 31 May 2021. The anonymised data of patients were abstracted from medical record review. Using the inclusion criteria according to World Health Organization definition, 207 patients with PIMS-TS were enrolled in this study. The incidence of PIMS-TS out of all SARS-CoV-2-positive children was 0.9:1,000. The estimated delay between the occurrence of PIMS-TS and the COVID-19 pandemic wave was 3 weeks. The significant initial predictors of myocardial dysfunction included mainly cardiovascular signs (hypotension, oedema, oliguria/anuria, and prolonged capillary refill). During follow-up, most patients (98.8%) had normal cardiac function, with no residual findings. No fatal cases were reported. Conclusions: A 3-week interval in combination with incidence of COVID-19 could help increase pre-test probability of PIMS-TS during pandemic waves in the suspected cases. Although the parameters of the models do not allow one to completely divide patients into high and low risk groups, knowing the most important predictors surely could help clinical management.
ER -
DAVID, Jan, Veronika STARA, Ondrej HRADSKY, Jana TUČKOVÁ, Kateřina SLABÁ, Petr JABANDŽIEV, Lumir SASEK, Michal HUML, Iveta ZIDKOVA, Jan PAVLICEK, Alzbeta PALATOVA, Eva KLASKOVA, Karina BANSZKA, Eva TERIFAJOVA, Radim VYHNANEK, Marketa BLOOMFIELD, Sarka FINGERHUTOVA, Pavla DOLEZALOVA, Lucie PROCHAZKOVA, Gabriela CHRAMOSTOVA, Filip FENCL and Jan LEBL. Nationwide observational study of paediatric inflammatory multisystem syndrome temporally associated with SARS-CoV-2 (PIMS-TS) in the Czech Republic. \textit{European journal of pediatrics}. New York: Springer, 2022, vol.~181, No~10, p.~3663-3672. ISSN~0340-6199. Available from: https://dx.doi.org/10.1007/s00431-022-04593-7.
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