Relapsing MRI-negative myelitis associated with
myelin-oligodendrocyte glycoprotein autoantibodies: a case
report

J 2022

Relapsing MRI-negative myelitis associated with myelin-oligodendrocyte glycoprotein autoantibodies: a case report

KOLČAVA, Jan, Aneta RAJDOVÁ, Eva VLČKOVÁ, Pavel ŠTOURAČ, Josef BEDNAŘÍK et. al.

Basic information

Original name

Relapsing MRI-negative myelitis associated with myelin-oligodendrocyte glycoprotein autoantibodies: a case report

Authors

KOLČAVA, Jan (203 Czech Republic, guarantor, belonging to the institution), Aneta RAJDOVÁ (203 Czech Republic, belonging to the institution), Eva VLČKOVÁ (203 Czech Republic, belonging to the institution), Pavel ŠTOURAČ (203 Czech Republic, belonging to the institution) and Josef BEDNAŘÍK (203 Czech Republic, belonging to the institution)

Edition

BMC Neurology, London, Biomed Central Ltd. 2022, 1471-2377

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30210 Clinical neurology

Country of publisher

United Kingdom of Great Britain and Northern Ireland

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 2.600

RIV identification code

RIV/00216224:14110/22:00128221

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.1186/s12883-022-02837-5

UT WoS

000844193100001

Keywords in English

Demyelinating diseases; Myelin-oligodendrocyte glycoprotein; Evoked potentials; Magnetic resonance imaging; Case report

Abstract

V originále

Background Serum antibodies to myelin-oligodendrocyte glycoprotein (MOG) are biomarkers of MOG-IgG-associated disorder (MOGAD), a demyelinating disease distinct from both multiple sclerosis and aquaporin-4-IgG neuromyelitis optica spectrum disorder. The phenotype of MOGAD is broad and includes optic neuritis, transverse myelitis, and acute demyelinating encephalomyelitis. Myelitis is common with MOGAD and typically results in acute and severe disability, although prospects for recovery are often favorable with prompt immunotherapy. Case presentation This contribution presents a unique case report of a young male patient exhibiting relapsing myelitis with normal spinal cord and brain magnetic resonance imaging. Comprehensive diagnostic assessment revealed myelin-oligodendrocyte glycoprotein-IgG-associated disorder. Conclusion MOGAD is one of the conditions which should be considered in MRI-negative myelitis. The diagnosis, however, may prove difficult, especially if the patient is not exhibiting other neurological symptoms of MOGAD. Conus or epiconus involvement is common in MOGAD; the patient reported herein exhibited incomplete rostral epiconus symptoms which, together with somatosensory evoked potential abnormalities, led to the diagnosis.

Links

MUNI/A/1144/2021, interní kód MU

Name: Diagnostika a patofyziologie neuropatické bolesti a dalších symptomů a komorbidit neurologických onemocnění

Investor: Masaryk University

MUNI/A/1600/2020, interní kód MU

Name: Diagnostika a patofyziologie neuropatické bolesti (Acronym: PNB)

Investor: Masaryk University

Citovat

KOLČAVA, Jan, Aneta RAJDOVÁ, Eva VLČKOVÁ, Pavel ŠTOURAČ and Josef BEDNAŘÍK. Relapsing MRI-negative myelitis associated with myelin-oligodendrocyte glycoprotein autoantibodies: a case report. BMC Neurology. London: Biomed Central Ltd., 2022, vol. 22, No 1, p. 1-6. ISSN 1471-2377. Available from: https://dx.doi.org/10.1186/s12883-022-02837-5.

@article{2249109,
   author = {Kolčava, Jan and Rajdová, Aneta and Vlčková, Eva and Štourač, Pavel and Bednařík, Josef},
   article_location = {London},
   article_number = {1},
   doi = {http://dx.doi.org/10.1186/s12883-022-02837-5},
   keywords = {Demyelinating diseases; Myelin-oligodendrocyte glycoprotein; Evoked potentials; Magnetic resonance imaging; Case report},
   language = {eng},
   issn = {1471-2377},
   journal = {BMC Neurology},
   title = {Relapsing MRI-negative myelitis associated with myelin-oligodendrocyte glycoprotein autoantibodies: a case report},
   url = {https://bmcneurol.biomedcentral.com/articles/10.1186/s12883-022-02837-5},
   volume = {22},
   year = {2022}
}

TY  - JOUR
ID  - 2249109
AU  - Kolčava, Jan - Rajdová, Aneta - Vlčková, Eva - Štourač, Pavel - Bednařík, Josef
PY  - 2022
TI  - Relapsing MRI-negative myelitis associated with myelin-oligodendrocyte glycoprotein autoantibodies: a case report
JF  - BMC Neurology
VL  - 22
IS  - 1
SP  - 1-6
EP  - 1-6
PB  - Biomed Central Ltd.
SN  - 14712377
KW  - Demyelinating diseases
KW  - Myelin-oligodendrocyte glycoprotein
KW  - Evoked potentials
KW  - Magnetic resonance imaging
KW  - Case report
UR  - https://bmcneurol.biomedcentral.com/articles/10.1186/s12883-022-02837-5
N2  - Background Serum antibodies to myelin-oligodendrocyte glycoprotein (MOG) are biomarkers of MOG-IgG-associated disorder (MOGAD), a demyelinating disease distinct from both multiple sclerosis and aquaporin-4-IgG neuromyelitis optica spectrum disorder. The phenotype of MOGAD is broad and includes optic neuritis, transverse myelitis, and acute demyelinating encephalomyelitis. Myelitis is common with MOGAD and typically results in acute and severe disability, although prospects for recovery are often favorable with prompt immunotherapy. Case presentation This contribution presents a unique case report of a young male patient exhibiting relapsing myelitis with normal spinal cord and brain magnetic resonance imaging. Comprehensive diagnostic assessment revealed myelin-oligodendrocyte glycoprotein-IgG-associated disorder. Conclusion MOGAD is one of the conditions which should be considered in MRI-negative myelitis. The diagnosis, however, may prove difficult, especially if the patient is not exhibiting other neurological symptoms of MOGAD. Conus or epiconus involvement is common in MOGAD; the patient reported herein exhibited incomplete rostral epiconus symptoms which, together with somatosensory evoked potential abnormalities, led to the diagnosis.
ER  -

KOLČAVA, Jan, Aneta RAJDOVÁ, Eva VLČKOVÁ, Pavel ŠTOURAČ and Josef BEDNAŘÍK. Relapsing MRI-negative myelitis associated with myelin-oligodendrocyte glycoprotein autoantibodies: a case report. \textit{BMC Neurology}. London: Biomed Central Ltd., 2022, vol.~22, No~1, p.~1-6. ISSN~1471-2377. Available from: https://dx.doi.org/10.1186/s12883-022-02837-5.

Detailed Information on Publication Record