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@article{2249116,
author = {Hacker, U. T. and Hasenclever, D. and Baber, R. and Linder, N. and Busse, H. and Obermannová, Radka and Zdražilová Dubská, Lenka and Valík, Dalibor and Lordick, F.},
article_location = {AMSTERDAM},
article_number = {7},
doi = {http://dx.doi.org/10.1016/j.annonc.2022.03.274},
keywords = {gastric cancer; sarcopenia; mean muscle attenuation; inflammation; modified Glasgow prognostic score; prognosis},
language = {eng},
issn = {0923-7534},
journal = {Annals of Oncology},
title = {Modified Glasgow prognostic score (mGPS) is correlated with sarcopenia and dominates the prognostic role of baseline body composition parameters in advanced gastric and esophagogastric junction cancer patients undergoing first-line treatment from the phase III EXPAND trial},
url = {https://www.sciencedirect.com/science/article/abs/pii/S0923753422006706?via%3Dihub},
volume = {33},
year = {2022}
}
TY - JOUR
ID - 2249116
AU - Hacker, U. T. - Hasenclever, D. - Baber, R. - Linder, N. - Busse, H. - Obermannová, Radka - Zdražilová Dubská, Lenka - Valík, Dalibor - Lordick, F.
PY - 2022
TI - Modified Glasgow prognostic score (mGPS) is correlated with sarcopenia and dominates the prognostic role of baseline body composition parameters in advanced gastric and esophagogastric junction cancer patients undergoing first-line treatment from the phase III EXPAND trial
JF - Annals of Oncology
VL - 33
IS - 7
SP - 685-692
EP - 685-692
PB - ELSEVIER
SN - 09237534
KW - gastric cancer
KW - sarcopenia
KW - mean muscle attenuation
KW - inflammation
KW - modified Glasgow prognostic score
KW - prognosis
UR - https://www.sciencedirect.com/science/article/abs/pii/S0923753422006706?via%3Dihub
N2 - Background: Sarcopenia represents an established adverse prognostic factor in cancer patients. Consequently, different means to counteract sarcopenia have been proposed to improve cancer treatment. Computed tomography (CT)-based measurements, also labor intensive, are well validated for the analysis of sarcopenia. As inflammation plays a key role in the development of sarcopenia, we here studied the role of the modified Glasgow prognostic score (mGPS), consisting of inflammation parameters plasma C-reactive protein (CRP) and albumin, to predicting sarcopenia and adipose tissuerelated body composition (BC) parameters at baseline and their changes during treatment and to analyze its prognostic role in conjunction with BC parameters. Patients and methods: CT measurements of BC parameters were carried out at baseline and week 12 in patients with advanced gastric or esophagogastric junction cancer from the phase III EXPAND trial, undergoing first-line platinumfluoropyrimidine chemotherapy. mGPS was calculated from baseline CRP and albumin plasma levels. Pearson correlation and Cox regression analyses were carried out. Results: mGPS is strongly prognostic for overall survival (OS). Baseline mGPS is significantly correlated with baseline mean muscle attenuation (MA; P < 0.0001). Baseline mGPS did not predict a decline in muscle or adipose tissue parameters during 12 weeks of treatment and a decline in muscle or adipose tissue parameters was not prognostic for OS. MA lost its prognostic role for OS when mGPS or CRP was entered into the Cox models. Eastern Cooperative Oncology Group performance status together with CRP or mGPS remained the sole baseline prognostic factors for OS. Conclusions: Our findings support a model where tumor-mediated inflammatory response represents a strong prognostic factor, which is causally related to sarcopenia, but with no direct causal path from sarcopenia to survival. Therefore, therapeutic targeting of systemic inflammation should be further explored as a promising strategy to improve both sarcopenia and the efficacy and tolerability of cancer treatment.
ER -
HACKER, U. T., D. HASENCLEVER, R. BABER, N. LINDER, H. BUSSE, Radka OBERMANNOVÁ, Lenka ZDRAŽILOVÁ DUBSKÁ, Dalibor VALÍK and F. LORDICK. Modified Glasgow prognostic score (mGPS) is correlated with sarcopenia and dominates the prognostic role of baseline body composition parameters in advanced gastric and esophagogastric junction cancer patients undergoing first-line treatment from the phase III EXPAND trial. \textit{Annals of Oncology}. AMSTERDAM: ELSEVIER, 2022, vol.~33, No~7, p.~685-692. ISSN~0923-7534. Available from: https://dx.doi.org/10.1016/j.annonc.2022.03.274.
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