Detailed Information on Publication Record
2022
Mineral Water Vincentka and its Influence on Mucosal Ulcers
BUDÍNSKÁ, Xenie, Jaroslav NÁDENÍČEK, Tibor STRAČINA, Michal HENDRYCH, Ondřej PÍREK et. al.Basic information
Original name
Mineral Water Vincentka and its Influence on Mucosal Ulcers
Authors
BUDÍNSKÁ, Xenie (203 Czech Republic, guarantor, belonging to the institution), Jaroslav NÁDENÍČEK (203 Czech Republic, belonging to the institution), Tibor STRAČINA (703 Slovakia, belonging to the institution), Michal HENDRYCH (203 Czech Republic, belonging to the institution), Ondřej PÍREK (203 Czech Republic, belonging to the institution), Anna BARTÁKOVÁ (203 Czech Republic, belonging to the institution), Magdaléna ŠUDÁKOVÁ (703 Slovakia, belonging to the institution), Vojtěch SVÍZELA (203 Czech Republic, belonging to the institution), Zuzana NOVÁKOVÁ (203 Czech Republic, belonging to the institution), Marie NOVÁKOVÁ (203 Czech Republic, belonging to the institution) and Petr BABULA (203 Czech Republic, belonging to the institution)
Edition
Physiological Research, Praha, Akademie věd České republiky, 2022, 0862-8408
Other information
Language
English
Type of outcome
Článek v odborném periodiku
Field of Study
30105 Physiology
Country of publisher
Czech Republic
Confidentiality degree
není předmětem státního či obchodního tajemství
References:
Impact factor
Impact factor: 2.100
RIV identification code
RIV/00216224:14110/22:00128244
Organization unit
Faculty of Medicine
UT WoS
000924861700010
Keywords in English
Mineral water Vincentka; Gastric ulcer; Oxidative stress
Tags
International impact, Reviewed
Změněno: 30/11/2023 12:24, Mgr. Tereza Miškechová
Abstract
V originále
Gastropathy is one of the most common diseases of the human gastrointestinal tract. Apart from its consequences in the stomach, it is also manifested in other parts of the digestive tract, particularly in the duodenum. The aim of this pilot study was to verify on animal model the empirically observed alleviation of gastropathy symptoms in patients who underwent a drinking treatment of Vincentka natural mineral water during their spa treatment. Sixteen male Wistar rats were included in the study. The animals were randomly divided into two groups: experimental group (E; n=8) and control group (C; n=8). The experimental protocol consisted of three phases: (1) handling phase (7 days); (2) mineral water (E)/tap water (C) administration (7 days); (3) acute gastritis induction (1 day). Twenty-four hours after the induction of acute gastritis, the animals were sacrificed. The collected tissues (stomach and duodenum) and blood were examined by standard histological microscopy, and by immunohistochemical and biochemical methods. Histopathological analysis revealed significantly reduced damage to the gastric mucosa in the experimental group. Significantly different values of blood plasma antioxidant capacity, oxidative stress parameters and blood plasma biochemical parameters were also found. Based on these results, we conclude that the mineral water Vincentka has a positive impact on development and symptoms of acute gastric ulcers.
Links
| MUNI/A/1133/2021, interní kód MU |
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