Detailed Information on Publication Record
2022
Effects of Peroral Hormonal Contraception on Cardiovascular System: Analysis of Selected Cardiovascular Parameters in an Adolescent Cohort; a Pilot Project
PÍREK, Ondřej, Xenie BUDÍNSKÁ and Zuzana NOVÁKOVÁBasic information
Original name
Effects of Peroral Hormonal Contraception on Cardiovascular System: Analysis of Selected Cardiovascular Parameters in an Adolescent Cohort; a Pilot Project
Authors
PÍREK, Ondřej (203 Czech Republic, belonging to the institution), Xenie BUDÍNSKÁ (203 Czech Republic, guarantor, belonging to the institution) and Zuzana NOVÁKOVÁ (203 Czech Republic, belonging to the institution)
Edition
Physiological Research, Praha, Akademie věd České republiky, 2022, 0862-8408
Other information
Language
English
Type of outcome
Článek v odborném periodiku
Field of Study
30105 Physiology
Country of publisher
Czech Republic
Confidentiality degree
není předmětem státního či obchodního tajemství
References:
Impact factor
Impact factor: 2.100
RIV identification code
RIV/00216224:14110/22:00128245
Organization unit
Faculty of Medicine
UT WoS
000924861700005
Keywords in English
Oral contraceptive pills; Arterial stiffness; Pulse wave velocity; Subendocardial viability index
Tags
International impact, Reviewed
Změněno: 2/3/2023 07:43, Mgr. Tereza Miškechová
Abstract
V originále
Oral contraceptive pills (OCPs) have some strong advantages over more traditional types of contraception, including their consistently high contraceptive effect as well as multiple additional positive side effects. OCPs went through decades of intense pharmaceutical development and current formulas are well optimized – however, a handful of their negative side effects remain, including some that affect cardiovascular system, for example higher risk of hypertension, venous thromboembolism and increased arterial stiffness. The gold standard for arterial stiffness assessment is currently applanation tonometry, a method that relies on arterial pulse wave velocity measurement (PWV). Another possible method for arterial stiffness measurement is the use of the VaSera device, which measures cardio-ankle vascular index (CAVI). The aim of this study was to discover the effect of OCPs use on selected cardiovascular parameters related to arterial stiffness. We measured these cardiovascular parameters in the OCPs using group (OCP) and in the control group (CTRL) using applanation tonometer Sphygmocor and the VaSera device. Comparison of the data from both groups showed us significantly increased diastolic blood pressure (DBP) and carotid-radial pulse wave velocity (crPWV) as well as significantly lower subendocardial viability index (SVI) in the OCP. These results imply a negative effect of hormonal contraceptives on the cardiovascular system with most of the negative changes affecting the peripheral arteries. Despite this evidence supporting the hypothesis of OCPs having a negative effect on cardiovascular health, further research is necessary.
Links
| MUNI/A/1133/2021, interní kód MU |
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