J 2022

Assessment of late cardiotoxic effects in patients treated for cancer in childhood

KINCL, Vladimír, Roman PANOVSKÝ, Tomáš KEPÁK, Viera BAJČIOVÁ, Veronika BEDNÁROVÁ et. al.

Basic information

Original name

Assessment of late cardiotoxic effects in patients treated for cancer in childhood

Authors

KINCL, Vladimír (203 Czech Republic, guarantor, belonging to the institution), Roman PANOVSKÝ (203 Czech Republic, belonging to the institution), Tomáš KEPÁK (203 Czech Republic, belonging to the institution), Viera BAJČIOVÁ (703 Slovakia, belonging to the institution), Veronika BEDNÁROVÁ (703 Slovakia, belonging to the institution), Lukáš OPATŘIL (203 Czech Republic, belonging to the institution) and Jan MÁCHAL (203 Czech Republic, belonging to the institution)

Edition

Cancer Medicine, HOBOKEN, John Wiley & Sons Ltd. 2022, 2045-7634

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30204 Oncology

Country of publisher

United States of America

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

Impact factor

Impact factor: 4.000

RIV identification code

RIV/00216224:14110/22:00128258

Organization unit

Faculty of Medicine

UT WoS

000761794900001

Keywords in English

late cardiotoxic effects; cancer in childhood

Tags

International impact, Reviewed
Změněno: 25/1/2023 09:24, Mgr. Tereza Miškechová

Abstract

V originále

Background: The most frequent chemotherapeutic regimens used in children's cancer contain anthracyclines, which may have potentially cardiotoxic effects even at a later point in time. Echocardiography including tissue Doppler imaging is well-proved noninvasive method to assess cardiac function. Objectives: To assess the late cardiotoxic effects in young adults treated for various cancer types in childhood. Methods: Ninety-eight young adults who were treated for childhood cancer (CCS), median time 12.1 years after finishing the therapy, were comprised into study. All subjects underwent echocardiographic examination including tissue Doppler imaging. The echocardiographic parameters were compared to 57 healthy age-matched subjects. The CCS group also underwent 24-h ECG Holter monitoring to reveal any arrhythmias. Results: The subjects in CCS group had lower E' velocities from lateral (15.6 vs. 17.6 cm/s) and septal part (12.2 vs. 14.4 cm/s) of mitral annulus (p for both <0.001) and also lower S' velocity from the tricuspid annulus (12.4. vs. 13.3 cm/s, p = 0.013) and tricuspid annulus peak systolic excursion (TAPSE; 22.2 vs. 23.9 mm, p = 0.017). There were no significant differences in left ventricular systolic velocities or ejection fraction. The occurrence of arrhythmias did not differ among subgroups of CCS with or without anthracycline therapy. Conclusion: Childhood cancer survivors had subclinical cardiac impairment in comparison with healthy controls, particularly in left ventricular diastolic function.

Links

MUNI/A/1685/2020, interní kód MU
Name: Nové trendy v diagnostice a terapii kardiomyopatií
Investor: Masaryk University