Detailed Information on Publication Record
2022
Assessment of late cardiotoxic effects in patients treated for cancer in childhood
KINCL, Vladimír, Roman PANOVSKÝ, Tomáš KEPÁK, Viera BAJČIOVÁ, Veronika BEDNÁROVÁ et. al.Basic information
Original name
Assessment of late cardiotoxic effects in patients treated for cancer in childhood
Authors
KINCL, Vladimír (203 Czech Republic, guarantor, belonging to the institution), Roman PANOVSKÝ (203 Czech Republic, belonging to the institution), Tomáš KEPÁK (203 Czech Republic, belonging to the institution), Viera BAJČIOVÁ (703 Slovakia, belonging to the institution), Veronika BEDNÁROVÁ (703 Slovakia, belonging to the institution), Lukáš OPATŘIL (203 Czech Republic, belonging to the institution) and Jan MÁCHAL (203 Czech Republic, belonging to the institution)
Edition
Cancer Medicine, HOBOKEN, John Wiley & Sons Ltd. 2022, 2045-7634
Other information
Language
English
Type of outcome
Článek v odborném periodiku
Field of Study
30204 Oncology
Country of publisher
United States of America
Confidentiality degree
není předmětem státního či obchodního tajemství
References:
Impact factor
Impact factor: 4.000
RIV identification code
RIV/00216224:14110/22:00128258
Organization unit
Faculty of Medicine
UT WoS
000761794900001
Keywords in English
late cardiotoxic effects; cancer in childhood
Tags
International impact, Reviewed
Změněno: 25/1/2023 09:24, Mgr. Tereza Miškechová
Abstract
V originále
Background: The most frequent chemotherapeutic regimens used in children's cancer contain anthracyclines, which may have potentially cardiotoxic effects even at a later point in time. Echocardiography including tissue Doppler imaging is well-proved noninvasive method to assess cardiac function. Objectives: To assess the late cardiotoxic effects in young adults treated for various cancer types in childhood. Methods: Ninety-eight young adults who were treated for childhood cancer (CCS), median time 12.1 years after finishing the therapy, were comprised into study. All subjects underwent echocardiographic examination including tissue Doppler imaging. The echocardiographic parameters were compared to 57 healthy age-matched subjects. The CCS group also underwent 24-h ECG Holter monitoring to reveal any arrhythmias. Results: The subjects in CCS group had lower E' velocities from lateral (15.6 vs. 17.6 cm/s) and septal part (12.2 vs. 14.4 cm/s) of mitral annulus (p for both <0.001) and also lower S' velocity from the tricuspid annulus (12.4. vs. 13.3 cm/s, p = 0.013) and tricuspid annulus peak systolic excursion (TAPSE; 22.2 vs. 23.9 mm, p = 0.017). There were no significant differences in left ventricular systolic velocities or ejection fraction. The occurrence of arrhythmias did not differ among subgroups of CCS with or without anthracycline therapy. Conclusion: Childhood cancer survivors had subclinical cardiac impairment in comparison with healthy controls, particularly in left ventricular diastolic function.
Links
| MUNI/A/1685/2020, interní kód MU |
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