J 2022

Higher Levels of Serum Ionic Calcium are Associated with Macular Edema in Patients with Diabetic Retinopathy

ANKITA, Ankita, Sandeep SAXENA, Mohammad K AHMAD, Dwividendra K NIM, Abbas A MAHDI et. al.

Basic information

Original name

Higher Levels of Serum Ionic Calcium are Associated with Macular Edema in Patients with Diabetic Retinopathy

Authors

ANKITA, Ankita, Sandeep SAXENA, Mohammad K AHMAD, Dwividendra K NIM, Abbas A MAHDI, Apjit KAUR, Shashi K BHASKER, Pavol VESELY, Jana STEFANICKOVA, Luis RODRIGO, Peter KRUŽLIAK (703 Slovakia, guarantor, belonging to the institution) and Vladimir KRASNIK

Edition

Clinical Laboratory, Heidelberg, Clin Lab Publications, 2022, 1433-6510

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30230 Other clinical medicine subjects

Country of publisher

Germany

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

Impact factor

Impact factor: 0.700

RIV identification code

RIV/00216224:14110/22:00128263

Organization unit

Faculty of Medicine

DOI

UT WoS

000749833000001

Keywords in English

diabetic retinopathy; diabetic macular edema; central subfield thickness; cube average thickness; ellipsoid zone

Tags

Tags

International impact, Reviewed
Změněno: 25/1/2023 10:41, Mgr. Tereza Miškechová

Abstract

V originále

Background: The aim was to study the association of serum total calcium, ionic calcium, and magnesium with increases in macular thickness parameters and photoreceptor ellipsoid zone (EZ) disruption in diabetic macular edema (DME). Methods: This study is a tertiary care center based observational cross-sectional study with sixty-six consecutive cases, divided into 3 groups of 22 cases each with no diabetic retinopathy (No DR), non-proliferative diabetic retinopathy (NPDR), and proliferative diabetic retinopathy (PDR) and a control group of 22 healthy controls. Best corrected visual acuity (BCVA) was measured on logMAR scale. Central subfield thickness (CST), cube average thickness (CAT), and EZ disruption were assessed using spectral-domain optical coherence tomography (SD-OCT). Serum total calcium, ionic calcium, and magnesium were measured using standard protocol. Data was analyzed statistically. Results: Significant correlation was found between the increase in CST and the increase in serum total calcium and serum ionic calcium. Increase in CAT was significantly correlated with an increase in serum total calcium, serum ionic calcium, and a decrease in serum magnesium. Grades of EZ disruption and logMAR BCVA were also found to be significantly positively associated with serum total calcium and ionic calcium and negatively with serum magnesium. Conclusions: Increased levels of serum ionic calcium and decreased levels of serum magnesium are associated with an increase in macular thickness and EZ disruption in DME.