Risk factors for tumors or leukemia development in the first
two years of life

J 2023

Risk factors for tumors or leukemia development in the first two years of life

WIEDERMANNOVA, Hana, Peter MÚDRY, Jan PAVLICEK, Hana TOMASKOVA, Andrea HLADIKOVA et. al.

Basic information

Original name

Risk factors for tumors or leukemia development in the first two years of life

Authors

WIEDERMANNOVA, Hana (203 Czech Republic), Peter MÚDRY (203 Czech Republic, belonging to the institution), Jan PAVLICEK (203 Czech Republic, guarantor), Hana TOMASKOVA (203 Czech Republic), Andrea HLADIKOVA (203 Czech Republic), Hana PÁLOVÁ (203 Czech Republic, belonging to the institution), Petra POKORNÁ (203 Czech Republic, belonging to the institution), Ondřej SLABÝ (203 Czech Republic, belonging to the institution) and Jaroslav ŠTĚRBA (203 Czech Republic, belonging to the institution)

Edition

Biomedical Papers, Olomouc: Palacky University, Olomouc, Palacky University, 2023, 1213-8118

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30205 Hematology

Country of publisher

Czech Republic

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 0.900 in 2022

RIV identification code

RIV/00216224:14110/23:00130240

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.5507/bp.2022.004

UT WoS

000757422200001

Keywords in English

neoplastic disease; epidemiology; risk factors; early-aged period

Abstract

V originále

Objectives. The objective of this study was to determine the incidence of neoplastic diseases and associated risk factors in the early stages of life. Methods. Data were retrospectively assessed in 730,000 live births between 2000 and 2019. The occurrence of tumors was monitored in the neonatal, infant (1-12 months), and toddler (13-24 months) periods. Risk factors were divided into demographic, internal, and environmental factors. The control group consisted of subjects in the same age category without oncological diseases. Results. A total of 452 neoplastic diseases were diagnosed in the study sample. In total, 24% (110/452) manifested during the neonatal period, 45% (203/452) in infants, and 31% (139/452) at the age of 13-24 months. Any genetic disease (OR 26.68; 95% CI 7.64-93.12) and medications used by the mother (OR 3.07; 95% CI 1.32-7.15) were identified as risk factors. Without adjustment for all factors, asphyxia in the first minute, a younger age of the mother, lower pregnancy, and the presence of a congenital defect manifested themselves as risk factors. Conclusions. The highest risk factors for the development of early childhood tumors were identified as with medications used by the mother before or during pregnancy and genetic diseases.

Links

MUNI/A/1427/2021, interní kód MU

Name: Personalizovaná léčba v dětské onkologii: na cestě k „liquid dynamic medicine“ a „N-of-1 clinical trials“

Investor: Masaryk University

NU20-03-00240, research and development project

Name: Celoexomové sekvenování, sekvenování genomu s nízkým pokrytím a transkriptomu pro účely precizní onkologie u dětských pacientů s vysoce rizikovými a relabovanými solidními nádory

Investor: Ministry of Health of the CR, Whole exome, low-coverage genome and transcriptome sequencing as tools for precision oncology in paediatric patients with high-risk and relapsed solid tumors, Subprogram 1 - standard

90091, large research infrastructures

Name: NCMG

Citovat

WIEDERMANNOVA, Hana, Peter MÚDRY, Jan PAVLICEK, Hana TOMASKOVA, Andrea HLADIKOVA, Hana PÁLOVÁ, Petra POKORNÁ, Ondřej SLABÝ and Jaroslav ŠTĚRBA. Risk factors for tumors or leukemia development in the first two years of life. Biomedical Papers, Olomouc: Palacky University. Olomouc: Palacky University, 2023, vol. 167, No 2, p. 246-253. ISSN 1213-8118. Available from: https://dx.doi.org/10.5507/bp.2022.004.

@article{2250015,
   author = {Wiedermannova, Hana and Múdry, Peter and Pavlicek, Jan and Tomaskova, Hana and Hladikova, Andrea and Pálová, Hana and Pokorná, Petra and Slabý, Ondřej and Štěrba, Jaroslav},
   article_location = {Olomouc},
   article_number = {2},
   doi = {http://dx.doi.org/10.5507/bp.2022.004},
   keywords = {neoplastic disease; epidemiology; risk factors; early-aged period},
   language = {eng},
   issn = {1213-8118},
   journal = {Biomedical Papers, Olomouc: Palacky University},
   title = {Risk factors for tumors or leukemia development in the first two years of life},
   url = {https://biomed.papers.upol.cz/corproof.php?tartkey=bio-000000-3123},
   volume = {167},
   year = {2023}
}

TY  - JOUR
ID  - 2250015
AU  - Wiedermannova, Hana - Múdry, Peter - Pavlicek, Jan - Tomaskova, Hana - Hladikova, Andrea - Pálová, Hana - Pokorná, Petra - Slabý, Ondřej - Štěrba, Jaroslav
PY  - 2023
TI  - Risk factors for tumors or leukemia development in the first two years of life
JF  - Biomedical Papers, Olomouc: Palacky University
VL  - 167
IS  - 2
SP  - 246-253
EP  - 246-253
PB  - Palacky University
SN  - 12138118
KW  - neoplastic disease
KW  - epidemiology
KW  - risk factors
KW  - early-aged period
UR  - https://biomed.papers.upol.cz/corproof.php?tartkey=bio-000000-3123
N2  - Objectives. The objective of this study was to determine the incidence of neoplastic diseases and associated risk factors in the early stages of life. Methods. Data were retrospectively assessed in 730,000 live births between 2000 and 2019. The occurrence of tumors was monitored in the neonatal, infant (1-12 months), and toddler (13-24 months) periods. Risk factors were divided into demographic, internal, and environmental factors. The control group consisted of subjects in the same age category without oncological diseases. Results. A total of 452 neoplastic diseases were diagnosed in the study sample. In total, 24% (110/452) manifested during the neonatal period, 45% (203/452) in infants, and 31% (139/452) at the age of 13-24 months. Any genetic disease (OR 26.68; 95% CI 7.64-93.12) and medications used by the mother (OR 3.07; 95% CI 1.32-7.15) were identified as risk factors. Without adjustment for all factors, asphyxia in the first minute, a younger age of the mother, lower pregnancy, and the presence of a congenital defect manifested themselves as risk factors. Conclusions. The highest risk factors for the development of early childhood tumors were identified as with medications used by the mother before or during pregnancy and genetic diseases.
ER  -

WIEDERMANNOVA, Hana, Peter MÚDRY, Jan PAVLICEK, Hana TOMASKOVA, Andrea HLADIKOVA, Hana PÁLOVÁ, Petra POKORNÁ, Ondřej SLABÝ and Jaroslav ŠTĚRBA. Risk factors for tumors or leukemia development in the first two years of life. \textit{Biomedical Papers, Olomouc: Palacky University}. Olomouc: Palacky University, 2023, vol.~167, No~2, p.~246-253. ISSN~1213-8118. Available from: https://dx.doi.org/10.5507/bp.2022.004.

Detailed Information on Publication Record