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@article{2250015,
author = {Wiedermannova, Hana and Múdry, Peter and Pavlicek, Jan and Tomaskova, Hana and Hladikova, Andrea and Pálová, Hana and Pokorná, Petra and Slabý, Ondřej and Štěrba, Jaroslav},
article_location = {Olomouc},
article_number = {2},
doi = {http://dx.doi.org/10.5507/bp.2022.004},
keywords = {neoplastic disease; epidemiology; risk factors; early-aged period},
language = {eng},
issn = {1213-8118},
journal = {Biomedical Papers, Olomouc: Palacky University},
title = {Risk factors for tumors or leukemia development in the first two years of life},
url = {https://biomed.papers.upol.cz/corproof.php?tartkey=bio-000000-3123},
volume = {167},
year = {2023}
}
TY - JOUR
ID - 2250015
AU - Wiedermannova, Hana - Múdry, Peter - Pavlicek, Jan - Tomaskova, Hana - Hladikova, Andrea - Pálová, Hana - Pokorná, Petra - Slabý, Ondřej - Štěrba, Jaroslav
PY - 2023
TI - Risk factors for tumors or leukemia development in the first two years of life
JF - Biomedical Papers, Olomouc: Palacky University
VL - 167
IS - 2
SP - 246-253
EP - 246-253
PB - Palacky University
SN - 12138118
KW - neoplastic disease
KW - epidemiology
KW - risk factors
KW - early-aged period
UR - https://biomed.papers.upol.cz/corproof.php?tartkey=bio-000000-3123
N2 - Objectives. The objective of this study was to determine the incidence of neoplastic diseases and associated risk factors in the early stages of life. Methods. Data were retrospectively assessed in 730,000 live births between 2000 and 2019. The occurrence of tumors was monitored in the neonatal, infant (1-12 months), and toddler (13-24 months) periods. Risk factors were divided into demographic, internal, and environmental factors. The control group consisted of subjects in the same age category without oncological diseases. Results. A total of 452 neoplastic diseases were diagnosed in the study sample. In total, 24% (110/452) manifested during the neonatal period, 45% (203/452) in infants, and 31% (139/452) at the age of 13-24 months. Any genetic disease (OR 26.68; 95% CI 7.64-93.12) and medications used by the mother (OR 3.07; 95% CI 1.32-7.15) were identified as risk factors. Without adjustment for all factors, asphyxia in the first minute, a younger age of the mother, lower pregnancy, and the presence of a congenital defect manifested themselves as risk factors. Conclusions. The highest risk factors for the development of early childhood tumors were identified as with medications used by the mother before or during pregnancy and genetic diseases.
ER -
WIEDERMANNOVA, Hana, Peter MÚDRY, Jan PAVLICEK, Hana TOMASKOVA, Andrea HLADIKOVA, Hana PÁLOVÁ, Petra POKORNÁ, Ondřej SLABÝ and Jaroslav ŠTĚRBA. Risk factors for tumors or leukemia development in the first two years of life. \textit{Biomedical Papers, Olomouc: Palacky University}. Olomouc: Palacky University, 2023, vol.~167, No~2, p.~246-253. ISSN~1213-8118. Available from: https://dx.doi.org/10.5507/bp.2022.004.
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