Progression from Subjective Cognitive Decline to Mild Cognitive
Impairment or Dementia: The Role of Baseline Cognitive
Performance

J 2022

Progression from Subjective Cognitive Decline to Mild Cognitive Impairment or Dementia: The Role of Baseline Cognitive Performance

JESTER, Dylan J., Martin VYHNALEK, Ross ANDEL, Hana MARKOVA, Tomas NIKOLAI et. al.

Basic information

Original name

Progression from Subjective Cognitive Decline to Mild Cognitive Impairment or Dementia: The Role of Baseline Cognitive Performance

Authors

JESTER, Dylan J. (guarantor), Martin VYHNALEK (203 Czech Republic), Ross ANDEL, Hana MARKOVA (203 Czech Republic), Tomas NIKOLAI, Jan LACZO, Veronika MATUSKOVA (203 Czech Republic), Katerina CECHOVA (203 Czech Republic), Kateřina SHEARDOVÁ (203 Czech Republic, belonging to the institution) and Jakub HORT (203 Czech Republic)

Edition

Journal of Alzheimers Disease, Amsterdam, IOS Press, 2022, 1387-2877

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30210 Clinical neurology

Country of publisher

Netherlands

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 4.000

RIV identification code

RIV/00216224:14110/22:00128319

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.3233/JAD-215291

UT WoS

000784452600020

Keywords in English

Cognitive aging; immediate recall; subjective memory complaints; verbal memory

Abstract

V originále

Background: Older adults with subjective cognitive decline (SCD) are at an increased risk of progression to mild cognitive impairment (MCI) or dementia. However, few have examined the specific cognitive tests that are associated with progression. Objective: This study examined performance on 18 neuropsychological tests among participants with SCD who later progressed to MCI or dementia. Methods: We included 131 participants from the Czech Brain Aging Study that had SCD at baseline. They completed a comprehensive neuropsychological battery including cognitive tests from the Uniform Data Set 2.0 enriched by the verbal memory test Rey Auditory Verbal Learning Test (RAVLT) and Rey-Osterrieth Complex Figure Test (ROCFT). Results: Fifty-five participants progressed: 53% to non-amnestic MCI (naMCI), 44% to amnestic MCI (aMCI), and 4% to dementia. Scoring one SD below the mean at baseline on the RAVLT 1 and RAVLT 1-5 was associated with 133% (RAVLT 1; HR: 2.33 [1.50, 3.62]) and 122% (RAVLT 1-5; HR: 2.22 [1.55, 3.16]) greater risk of progression to MCI or dementia over 3.84 years on average. Worse performance on the RAVLT 5, RAVLT 1-5, RAVLT 30, and ROCFT-Recall was associated with progression to aMCI whereas worse performance on the RAVLT 1, TMT B, and Boston Naming Test was associated with progression to naMCI. Conclusion: At baseline, lower verbal memory performance was most strongly associated with progression to aMCI whereas lower executive or language performance was most strongly associated with progression to naMCI.

Citovat

JESTER, Dylan J., Martin VYHNALEK, Ross ANDEL, Hana MARKOVA, Tomas NIKOLAI, Jan LACZO, Veronika MATUSKOVA, Katerina CECHOVA, Kateřina SHEARDOVÁ and Jakub HORT. Progression from Subjective Cognitive Decline to Mild Cognitive Impairment or Dementia: The Role of Baseline Cognitive Performance. Journal of Alzheimers Disease. Amsterdam: IOS Press, 2022, vol. 86, No 4, p. 1763-1774. ISSN 1387-2877. Available from: https://dx.doi.org/10.3233/JAD-215291.

@article{2250038,
   author = {Jester, Dylan J. and Vyhnalek, Martin and Andel, Ross and Markova, Hana and Nikolai, Tomas and Laczo, Jan and Matuskova, Veronika and Cechova, Katerina and Sheardová, Kateřina and Hort, Jakub},
   article_location = {Amsterdam},
   article_number = {4},
   doi = {http://dx.doi.org/10.3233/JAD-215291},
   keywords = {Cognitive aging; immediate recall; subjective memory complaints; verbal memory},
   language = {eng},
   issn = {1387-2877},
   journal = {Journal of Alzheimers Disease},
   title = {Progression from Subjective Cognitive Decline to Mild Cognitive Impairment or Dementia: The Role of Baseline Cognitive Performance},
   url = {https://content.iospress.com/articles/journal-of-alzheimers-disease/jad215291},
   volume = {86},
   year = {2022}
}

TY  - JOUR
ID  - 2250038
AU  - Jester, Dylan J. - Vyhnalek, Martin - Andel, Ross - Markova, Hana - Nikolai, Tomas - Laczo, Jan - Matuskova, Veronika - Cechova, Katerina - Sheardová, Kateřina - Hort, Jakub
PY  - 2022
TI  - Progression from Subjective Cognitive Decline to Mild Cognitive Impairment or Dementia: The Role of Baseline Cognitive Performance
JF  - Journal of Alzheimers Disease
VL  - 86
IS  - 4
SP  - 1763-1774
EP  - 1763-1774
PB  - IOS Press
SN  - 13872877
KW  - Cognitive aging
KW  - immediate recall
KW  - subjective memory complaints
KW  - verbal memory
UR  - https://content.iospress.com/articles/journal-of-alzheimers-disease/jad215291
N2  - Background: Older adults with subjective cognitive decline (SCD) are at an increased risk of progression to mild cognitive impairment (MCI) or dementia. However, few have examined the specific cognitive tests that are associated with progression. Objective: This study examined performance on 18 neuropsychological tests among participants with SCD who later progressed to MCI or dementia. Methods: We included 131 participants from the Czech Brain Aging Study that had SCD at baseline. They completed a comprehensive neuropsychological battery including cognitive tests from the Uniform Data Set 2.0 enriched by the verbal memory test Rey Auditory Verbal Learning Test (RAVLT) and Rey-Osterrieth Complex Figure Test (ROCFT). Results: Fifty-five participants progressed: 53% to non-amnestic MCI (naMCI), 44% to amnestic MCI (aMCI), and 4% to dementia. Scoring one SD below the mean at baseline on the RAVLT 1 and RAVLT 1-5 was associated with 133% (RAVLT 1; HR: 2.33 [1.50, 3.62]) and 122% (RAVLT 1-5; HR: 2.22 [1.55, 3.16]) greater risk of progression to MCI or dementia over 3.84 years on average. Worse performance on the RAVLT 5, RAVLT 1-5, RAVLT 30, and ROCFT-Recall was associated with progression to aMCI whereas worse performance on the RAVLT 1, TMT B, and Boston Naming Test was associated with progression to naMCI. Conclusion: At baseline, lower verbal memory performance was most strongly associated with progression to aMCI whereas lower executive or language performance was most strongly associated with progression to naMCI.
ER  -

JESTER, Dylan J., Martin VYHNALEK, Ross ANDEL, Hana MARKOVA, Tomas NIKOLAI, Jan LACZO, Veronika MATUSKOVA, Katerina CECHOVA, Kateřina SHEARDOVÁ and Jakub HORT. Progression from Subjective Cognitive Decline to Mild Cognitive Impairment or Dementia: The Role of Baseline Cognitive Performance. \textit{Journal of Alzheimers Disease}. Amsterdam: IOS Press, 2022, vol.~86, No~4, p.~1763-1774. ISSN~1387-2877. Available from: https://dx.doi.org/10.3233/JAD-215291.

Detailed Information on Publication Record