J 2022

Progression from Subjective Cognitive Decline to Mild Cognitive Impairment or Dementia: The Role of Baseline Cognitive Performance

JESTER, Dylan J., Martin VYHNALEK, Ross ANDEL, Hana MARKOVA, Tomas NIKOLAI et. al.

Basic information

Original name

Progression from Subjective Cognitive Decline to Mild Cognitive Impairment or Dementia: The Role of Baseline Cognitive Performance

Authors

JESTER, Dylan J. (guarantor), Martin VYHNALEK (203 Czech Republic), Ross ANDEL, Hana MARKOVA (203 Czech Republic), Tomas NIKOLAI, Jan LACZO, Veronika MATUSKOVA (203 Czech Republic), Katerina CECHOVA (203 Czech Republic), Kateřina SHEARDOVÁ (203 Czech Republic, belonging to the institution) and Jakub HORT (203 Czech Republic)

Edition

Journal of Alzheimers Disease, Amsterdam, IOS Press, 2022, 1387-2877

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30210 Clinical neurology

Country of publisher

Netherlands

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

Impact factor

Impact factor: 4.000

RIV identification code

RIV/00216224:14110/22:00128319

Organization unit

Faculty of Medicine

DOI

UT WoS

000784452600020

Keywords in English

Cognitive aging; immediate recall; subjective memory complaints; verbal memory

Tags

Tags

International impact, Reviewed
Změněno: 27/1/2023 11:13, Mgr. Tereza Miškechová

Abstract

V originále

Background: Older adults with subjective cognitive decline (SCD) are at an increased risk of progression to mild cognitive impairment (MCI) or dementia. However, few have examined the specific cognitive tests that are associated with progression. Objective: This study examined performance on 18 neuropsychological tests among participants with SCD who later progressed to MCI or dementia. Methods: We included 131 participants from the Czech Brain Aging Study that had SCD at baseline. They completed a comprehensive neuropsychological battery including cognitive tests from the Uniform Data Set 2.0 enriched by the verbal memory test Rey Auditory Verbal Learning Test (RAVLT) and Rey-Osterrieth Complex Figure Test (ROCFT). Results: Fifty-five participants progressed: 53% to non-amnestic MCI (naMCI), 44% to amnestic MCI (aMCI), and 4% to dementia. Scoring one SD below the mean at baseline on the RAVLT 1 and RAVLT 1-5 was associated with 133% (RAVLT 1; HR: 2.33 [1.50, 3.62]) and 122% (RAVLT 1-5; HR: 2.22 [1.55, 3.16]) greater risk of progression to MCI or dementia over 3.84 years on average. Worse performance on the RAVLT 5, RAVLT 1-5, RAVLT 30, and ROCFT-Recall was associated with progression to aMCI whereas worse performance on the RAVLT 1, TMT B, and Boston Naming Test was associated with progression to naMCI. Conclusion: At baseline, lower verbal memory performance was most strongly associated with progression to aMCI whereas lower executive or language performance was most strongly associated with progression to naMCI.