Radiation-associated angiosarcoma of the breast: An
international multicenter analysis

J 2022

Radiation-associated angiosarcoma of the breast: An international multicenter analysis

MERGANCOVA, Jana, Anna LIEROVA, Oldřich COUFAL, Jan ZATECKY, Bohuslav MELICHAR et. al.

Basic information

Original name

Radiation-associated angiosarcoma of the breast: An international multicenter analysis

Authors

MERGANCOVA, Jana (203 Czech Republic), Anna LIEROVA (203 Czech Republic), Oldřich COUFAL (203 Czech Republic, belonging to the institution), Jan ZATECKY (203 Czech Republic), Bohuslav MELICHAR (203 Czech Republic), Ilona ZEDNIKOVA (203 Czech Republic), Jindriska MERGANCOVA (203 Czech Republic), Anna JESENKOVA (203 Czech Republic), Karel STASTNY (203 Czech Republic), Jiri GATEK (203 Czech Republic), Otakar KUBALA (203 Czech Republic), Jiri PROKOP (203 Czech Republic), Daniel DYTTERT, Marian KARABA, Ivana SCHWARZBACHEROVA (203 Czech Republic), Anna HUMENANSKA (203 Czech Republic), Jindrich SUK (203 Czech Republic), Michal VALENTA (203 Czech Republic), Vladimir MOUCHA (203 Czech Republic), Lukas SAKRA (203 Czech Republic), Ales HLAVKA (203 Czech Republic), Maria HACOVA (203 Czech Republic), Radovan VOJTISEK (203 Czech Republic), Marek SOCHOR (203 Czech Republic), Tomas JIRASEK (203 Czech Republic), Michaela ZABOJNIKOVA (203 Czech Republic), Martina ZEMANOVA, Katarina MACHALEKOVA, Dominika RUSNAKOVA, Eva KUDELOVA and Marek SMOLAR (guarantor)

Edition

SURGICAL ONCOLOGY-OXFORD, OXFORD, ELSEVIER SCI LTD, 2022, 0960-7404

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30204 Oncology

Country of publisher

United Kingdom of Great Britain and Northern Ireland

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 2.300

RIV identification code

RIV/00216224:14110/22:00128320

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.1016/j.suronc.2022.101726

UT WoS

000789993900010

Keywords in English

Radiation; Angiosarcoma; Breast; Multicenter study

Abstract

V originále

Introduction: Radiation-associated angiosarcoma (RAAS) is a rare and serious complication of breast irradiation. Due to the rarity of the condition, clinical experience is limited and publications on this topic include only retrospective studies or case reports.Materials and methods: All patients diagnosed with RAAS between January 2000 and December 2017 in twelve centers across the Czech Republic and Slovakia were evaluated.Results: Data of 53 patients were analyzed. The median age at diagnosis was 72 (range 44-89) years. The median latency period between irradiation and diagnosis of RAAS was 78 (range 36-172) months. The median radiation dose was 57.6 (range 34-66) Gy. The whole breast radiation therapy with radiation boost to the tumor bed was the most common radiotherapy regimen. Total mastectomy due to RAAS was performed in 43 patients (81%), radical excision in 8 (15%); 2 patients were not surgically treated due to unresectable disease. Adjuvant chemotherapy followed surgical therapy of RAAS in 18 patients, 3 patients underwent adjuvant radiotherapy. The local recurrence rate of RAAS was 43% and the median time from surgery to the onset of recurrence was 7.5 months (range 3-66 months). The 3-year survival rate was 56%, the 5-year survival rate was only 33%. 46% of patients died during the follow-up period.Conclusion: The present data demonstrate that RAAS is a rare condition with high local recurrence rate (43%) and mortality (the 5-year survival rate was 33%.). Early diagnosis of RAAS based on biopsy is crucial for treatment with radical intent. Surgery with negative margins constitutes the most important part of the therapy; the role of adjuvant chemotherapy and radiotherapy is still unclear.

Citovat

MERGANCOVA, Jana, Anna LIEROVA, Oldřich COUFAL, Jan ZATECKY, Bohuslav MELICHAR, Ilona ZEDNIKOVA, Jindriska MERGANCOVA, Anna JESENKOVA, Karel STASTNY, Jiri GATEK, Otakar KUBALA, Jiri PROKOP, Daniel DYTTERT, Marian KARABA, Ivana SCHWARZBACHEROVA, Anna HUMENANSKA, Jindrich SUK, Michal VALENTA, Vladimir MOUCHA, Lukas SAKRA, Ales HLAVKA, Maria HACOVA, Radovan VOJTISEK, Marek SOCHOR, Tomas JIRASEK, Michaela ZABOJNIKOVA, Martina ZEMANOVA, Katarina MACHALEKOVA, Dominika RUSNAKOVA, Eva KUDELOVA and Marek SMOLAR. Radiation-associated angiosarcoma of the breast: An international multicenter analysis. SURGICAL ONCOLOGY-OXFORD. OXFORD: ELSEVIER SCI LTD, 2022, vol. 41, May 2022, p. 1-8. ISSN 0960-7404. Available from: https://dx.doi.org/10.1016/j.suronc.2022.101726.

@article{2250039,
   author = {Mergancova, Jana and Lierova, Anna and Coufal, Oldřich and Zatecky, Jan and Melichar, Bohuslav and Zednikova, Ilona and Mergancova, Jindriska and Jesenkova, Anna and Stastny, Karel and Gatek, Jiri and Kubala, Otakar and Prokop, Jiri and Dyttert, Daniel and Karaba, Marian and Schwarzbacherova, Ivana and Humenanska, Anna and Suk, Jindrich and Valenta, Michal and Moucha, Vladimir and Sakra, Lukas and Hlavka, Ales and Hacova, Maria and Vojtisek, Radovan and Sochor, Marek and Jirasek, Tomas and Zabojnikova, Michaela and Zemanova, Martina and Machalekova, Katarina and Rusnakova, Dominika and Kudelova, Eva and Smolar, Marek},
   article_location = {OXFORD},
   article_number = {May 2022},
   doi = {http://dx.doi.org/10.1016/j.suronc.2022.101726},
   keywords = {Radiation; Angiosarcoma; Breast; Multicenter study},
   language = {eng},
   issn = {0960-7404},
   journal = {SURGICAL ONCOLOGY-OXFORD},
   title = {Radiation-associated angiosarcoma of the breast: An international multicenter analysis},
   url = {https://www.sciencedirect.com/science/article/pii/S0960740422000196?via%3Dihub},
   volume = {41},
   year = {2022}
}

TY  - JOUR
ID  - 2250039
AU  - Mergancova, Jana - Lierova, Anna - Coufal, Oldřich - Zatecky, Jan - Melichar, Bohuslav - Zednikova, Ilona - Mergancova, Jindriska - Jesenkova, Anna - Stastny, Karel - Gatek, Jiri - Kubala, Otakar - Prokop, Jiri - Dyttert, Daniel - Karaba, Marian - Schwarzbacherova, Ivana - Humenanska, Anna - Suk, Jindrich - Valenta, Michal - Moucha, Vladimir - Sakra, Lukas - Hlavka, Ales - Hacova, Maria - Vojtisek, Radovan - Sochor, Marek - Jirasek, Tomas - Zabojnikova, Michaela - Zemanova, Martina - Machalekova, Katarina - Rusnakova, Dominika - Kudelova, Eva - Smolar, Marek
PY  - 2022
TI  - Radiation-associated angiosarcoma of the breast: An international multicenter analysis
JF  - SURGICAL ONCOLOGY-OXFORD
VL  - 41
IS  - May 2022
SP  - 1-8
EP  - 1-8
PB  - ELSEVIER SCI LTD
SN  - 09607404
KW  - Radiation
KW  - Angiosarcoma
KW  - Breast
KW  - Multicenter study
UR  - https://www.sciencedirect.com/science/article/pii/S0960740422000196?via%3Dihub
N2  - Introduction: Radiation-associated angiosarcoma (RAAS) is a rare and serious complication of breast irradiation. Due to the rarity of the condition, clinical experience is limited and publications on this topic include only retrospective studies or case reports.Materials and methods: All patients diagnosed with RAAS between January 2000 and December 2017 in twelve centers across the Czech Republic and Slovakia were evaluated.Results: Data of 53 patients were analyzed. The median age at diagnosis was 72 (range 44-89) years. The median latency period between irradiation and diagnosis of RAAS was 78 (range 36-172) months. The median radiation dose was 57.6 (range 34-66) Gy. The whole breast radiation therapy with radiation boost to the tumor bed was the most common radiotherapy regimen. Total mastectomy due to RAAS was performed in 43 patients (81%), radical excision in 8 (15%); 2 patients were not surgically treated due to unresectable disease. Adjuvant chemotherapy followed surgical therapy of RAAS in 18 patients, 3 patients underwent adjuvant radiotherapy. The local recurrence rate of RAAS was 43% and the median time from surgery to the onset of recurrence was 7.5 months (range 3-66 months). The 3-year survival rate was 56%, the 5-year survival rate was only 33%. 46% of patients died during the follow-up period.Conclusion: The present data demonstrate that RAAS is a rare condition with high local recurrence rate (43%) and mortality (the 5-year survival rate was 33%.). Early diagnosis of RAAS based on biopsy is crucial for treatment with radical intent. Surgery with negative margins constitutes the most important part of the therapy; the role of adjuvant chemotherapy and radiotherapy is still unclear.
ER  -

MERGANCOVA, Jana, Anna LIEROVA, Oldřich COUFAL, Jan ZATECKY, Bohuslav MELICHAR, Ilona ZEDNIKOVA, Jindriska MERGANCOVA, Anna JESENKOVA, Karel STASTNY, Jiri GATEK, Otakar KUBALA, Jiri PROKOP, Daniel DYTTERT, Marian KARABA, Ivana SCHWARZBACHEROVA, Anna HUMENANSKA, Jindrich SUK, Michal VALENTA, Vladimir MOUCHA, Lukas SAKRA, Ales HLAVKA, Maria HACOVA, Radovan VOJTISEK, Marek SOCHOR, Tomas JIRASEK, Michaela ZABOJNIKOVA, Martina ZEMANOVA, Katarina MACHALEKOVA, Dominika RUSNAKOVA, Eva KUDELOVA and Marek SMOLAR. Radiation-associated angiosarcoma of the breast: An international multicenter analysis. \textit{SURGICAL ONCOLOGY-OXFORD}. OXFORD: ELSEVIER SCI LTD, 2022, vol.~41, May 2022, p.~1-8. ISSN~0960-7404. Available from: https://dx.doi.org/10.1016/j.suronc.2022.101726.

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