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@article{2250049,
author = {Morando, Nicolas and Vrbová, Eliška and Melgar, Asunta and Rabinovich, Roberto Daniel and Šmajs, David and Pando, Maria A},
article_location = {Berlin},
article_number = {1},
doi = {http://dx.doi.org/10.1038/s41598-022-20410-5},
keywords = {Nichols-like strains; Treponema pallidum; macrolide resistance},
language = {eng},
issn = {2045-2322},
journal = {Nature Scientific Reports},
title = {High frequency of Nichols-like strains and increased levels of macrolide resistance in Treponema pallidum in clinical samples from Buenos Aires, Argentina},
url = {https://www.nature.com/articles/s41598-022-20410-5},
volume = {12},
year = {2022}
}
TY - JOUR
ID - 2250049
AU - Morando, Nicolas - Vrbová, Eliška - Melgar, Asunta - Rabinovich, Roberto Daniel - Šmajs, David - Pando, Maria A
PY - 2022
TI - High frequency of Nichols-like strains and increased levels of macrolide resistance in Treponema pallidum in clinical samples from Buenos Aires, Argentina
JF - Nature Scientific Reports
VL - 12
IS - 1
SP - 1-10
EP - 1-10
PB - NATURE RESEARCH
SN - 20452322
KW - Nichols-like strains
KW - Treponema pallidum
KW - macrolide resistance
UR - https://www.nature.com/articles/s41598-022-20410-5
N2 - Globally, 94% of Treponema pallidum subsp. pallidum (TPA) clinical strains belong to the SS14-like group and 6% to the Nichols-like group, with a prevalence of macrolide resistance of 90%. Our goal was to determine whether local TPA strain distribution and macrolide resistance frequency have changed significantly since our last report, which revealed that Buenos Aires had a high frequency of Nichols-like strains (27%) and low levels of macrolide resistance (14%). Swab samples from patients with suspected syphilis were collected during 2015-2019 and loci TP0136, TP0548, TP0705 were sequenced in order to perform multilocus sequence typing. Strains were classified as Nichols-like or SS14-like. The presence of macrolide resistance-associated mutations was determined by examination of the 23S rDNA gene sequence. Of 46 typeable samples, 37% were classified as Nichols-like and 63% as SS14-like. Macrolide resistance prevalence was 45.7%. Seven allelic profiles were found, five were SS14-like and two were Nichols-like. The frequency of Nichols-like strains increased between studies (26.8% vs. 37%, p = 0.36). A dramatic increase was found in the frequency of macrolide resistant strains between studies (14.3% vs. 45.7%, p = 0.005). Our results are in agreement with international trends and underscore the need to pursue further TPA molecular typing studies in South America.
ER -
MORANDO, Nicolas, Eliška VRBOVÁ, Asunta MELGAR, Roberto Daniel RABINOVICH, David ŠMAJS and Maria A PANDO. High frequency of Nichols-like strains and increased levels of macrolide resistance in Treponema pallidum in clinical samples from Buenos Aires, Argentina. \textit{Nature Scientific Reports}. Berlin: NATURE RESEARCH, 2022, vol.~12, No~1, p.~1-10. ISSN~2045-2322. Available from: https://dx.doi.org/10.1038/s41598-022-20410-5.
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