Quantitative MR Markers in Non-Myelopathic Spinal Cord
Compression: A Narrative Review

J 2022

Quantitative MR Markers in Non-Myelopathic Spinal Cord Compression: A Narrative Review

VALOSEK, Jan, Petr BEDNARIK, Miloš KEŘKOVSKÝ, Petr HLUSTIK, Josef BEDNAŘÍK et. al.

Basic information

Original name

Quantitative MR Markers in Non-Myelopathic Spinal Cord Compression: A Narrative Review

Authors

VALOSEK, Jan (203 Czech Republic), Petr BEDNARIK (203 Czech Republic), Miloš KEŘKOVSKÝ (203 Czech Republic, belonging to the institution), Petr HLUSTIK (203 Czech Republic), Josef BEDNAŘÍK (203 Czech Republic, belonging to the institution) and Alena SVATKOVA (203 Czech Republic)

Edition

Journal of Clinical Medicine, BASEL, MDPI, 2022, 2077-0383

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30210 Clinical neurology

Country of publisher

Switzerland

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 3.900

RIV identification code

RIV/00216224:14110/22:00128326

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.3390/jcm11092301

UT WoS

000794815500001

Keywords in English

non-myelopathic cervical spinal cord compression; degenerative cervical myelopathy; diffusion magnetic resonance imaging; quantitative magnetic resonance imaging

Abstract

V originále

Degenerative spinal cord compression is a frequent pathological condition with increasing prevalence throughout aging. Initial non-myelopathic cervical spinal cord compression (NMDC) might progress over time into potentially irreversible degenerative cervical myelopathy (DCM). While quantitative MRI (qMRI) techniques demonstrated the ability to depict intrinsic tissue properties, longitudinal in-vivo biomarkers to identify NMDC patients who will eventually develop DCM are still missing. Thus, we aim to review the ability of qMRI techniques (such as diffusion MRI, diffusion tensor imaging (DTI), magnetization transfer (MT) imaging, and magnetic resonance spectroscopy (H-1-MRS)) to serve as prognostic markers in NMDC. While DTI in NMDC patients consistently detected lower fractional anisotropy and higher mean diffusivity at compressed levels, caused by demyelination and axonal injury, MT and H-1-MRS, along with advanced and tract-specific diffusion MRI, recently revealed microstructural alterations, also rostrally pointing to Wallerian degeneration. Recent studies also disclosed a significant relationship between microstructural damage and functional deficits, as assessed by qMRI and electrophysiology, respectively. Thus, tract-specific qMRI, in combination with electrophysiology, critically extends our understanding of the underlying pathophysiology of degenerative spinal cord compression and may provide predictive markers of DCM development for accurate patient management. However, the prognostic value must be validated in longitudinal studies.

Links

NU22-04-00024, research and development project

Name: Kvantitativní zobrazovací MR parametry jako prediktory průběhu nemyelopatické degenerativní komprese krční míchy: longitudinální studie

Investor: Ministry of Health of the CR, Quantitative magnetic resonance imaging parameters as predictors of outcome of non-myelopathic degenerative cervical cord compression: a longitudinal study, Subprogram 1 - standard

NV18-04-00159, research and development project

Name: Využití pokročilých magneticko-rezonančních technik k odhalení patofyziologie a zlepšení diagnostiky a praktického managementu degenerativní komprese krční míchy

Investor: Ministry of Health of the CR

90129, large research infrastructures

Name: Czech-BioImaging II

Citovat

VALOSEK, Jan, Petr BEDNARIK, Miloš KEŘKOVSKÝ, Petr HLUSTIK, Josef BEDNAŘÍK and Alena SVATKOVA. Quantitative MR Markers in Non-Myelopathic Spinal Cord Compression: A Narrative Review. Journal of Clinical Medicine. BASEL: MDPI, 2022, vol. 11, No 9, p. 1-21. ISSN 2077-0383. Available from: https://dx.doi.org/10.3390/jcm11092301.

@article{2250057,
   author = {Valosek, Jan and Bednarik, Petr and Keřkovský, Miloš and Hlustik, Petr and Bednařík, Josef and Svatkova, Alena},
   article_location = {BASEL},
   article_number = {9},
   doi = {http://dx.doi.org/10.3390/jcm11092301},
   keywords = {non-myelopathic cervical spinal cord compression; degenerative cervical myelopathy; diffusion magnetic resonance imaging; quantitative magnetic resonance imaging},
   language = {eng},
   issn = {2077-0383},
   journal = {Journal of Clinical Medicine},
   title = {Quantitative MR Markers in Non-Myelopathic Spinal Cord Compression: A Narrative Review},
   url = {https://www.mdpi.com/2077-0383/11/9/2301},
   volume = {11},
   year = {2022}
}

TY  - JOUR
ID  - 2250057
AU  - Valosek, Jan - Bednarik, Petr - Keřkovský, Miloš - Hlustik, Petr - Bednařík, Josef - Svatkova, Alena
PY  - 2022
TI  - Quantitative MR Markers in Non-Myelopathic Spinal Cord Compression: A Narrative Review
JF  - Journal of Clinical Medicine
VL  - 11
IS  - 9
SP  - 1-21
EP  - 1-21
PB  - MDPI
SN  - 20770383
KW  - non-myelopathic cervical spinal cord compression
KW  - degenerative cervical myelopathy
KW  - diffusion magnetic resonance imaging
KW  - quantitative magnetic resonance imaging
UR  - https://www.mdpi.com/2077-0383/11/9/2301
N2  - Degenerative spinal cord compression is a frequent pathological condition with increasing prevalence throughout aging. Initial non-myelopathic cervical spinal cord compression (NMDC) might progress over time into potentially irreversible degenerative cervical myelopathy (DCM). While quantitative MRI (qMRI) techniques demonstrated the ability to depict intrinsic tissue properties, longitudinal in-vivo biomarkers to identify NMDC patients who will eventually develop DCM are still missing. Thus, we aim to review the ability of qMRI techniques (such as diffusion MRI, diffusion tensor imaging (DTI), magnetization transfer (MT) imaging, and magnetic resonance spectroscopy (H-1-MRS)) to serve as prognostic markers in NMDC. While DTI in NMDC patients consistently detected lower fractional anisotropy and higher mean diffusivity at compressed levels, caused by demyelination and axonal injury, MT and H-1-MRS, along with advanced and tract-specific diffusion MRI, recently revealed microstructural alterations, also rostrally pointing to Wallerian degeneration. Recent studies also disclosed a significant relationship between microstructural damage and functional deficits, as assessed by qMRI and electrophysiology, respectively. Thus, tract-specific qMRI, in combination with electrophysiology, critically extends our understanding of the underlying pathophysiology of degenerative spinal cord compression and may provide predictive markers of DCM development for accurate patient management. However, the prognostic value must be validated in longitudinal studies.
ER  -

VALOSEK, Jan, Petr BEDNARIK, Miloš KEŘKOVSKÝ, Petr HLUSTIK, Josef BEDNAŘÍK and Alena SVATKOVA. Quantitative MR Markers in Non-Myelopathic Spinal Cord Compression: A Narrative Review. \textit{Journal of Clinical Medicine}. BASEL: MDPI, 2022, vol.~11, No~9, p.~1-21. ISSN~2077-0383. Available from: https://dx.doi.org/10.3390/jcm11092301.

Detailed Information on Publication Record