Efficacy and safety of higher oral doses of azaperone to
achieve sedation in pigs

J 2022

Efficacy and safety of higher oral doses of azaperone to achieve sedation in pigs

SVOBODA, Martin, Jana BLAHOVA, Martin HOSTOVSKY, Jiří JARKOVSKÝ, Jakub NETOLICKY et. al.

Basic information

Original name

Efficacy and safety of higher oral doses of azaperone to achieve sedation in pigs

Authors

SVOBODA, Martin (203 Czech Republic, guarantor), Jana BLAHOVA (203 Czech Republic), Martin HOSTOVSKY (203 Czech Republic), Jiří JARKOVSKÝ (203 Czech Republic, belonging to the institution), Jakub NETOLICKY (203 Czech Republic), Patrik PREDNY (203 Czech Republic), Ivana SIMKOVA (203 Czech Republic), Jonas VANHARA (203 Czech Republic) and Jan VASEK (203 Czech Republic)

Edition

Veterinarni Medicina, Praha, Czech Academy of Agricultural Sciences, 2022, 0375-8427

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

40301 Veterinary science

Country of publisher

Czech Republic

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 0.700

RIV identification code

RIV/00216224:14110/22:00128412

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.17221/56/2022-VETMED

UT WoS

000868736000001

Keywords in English

behaviour; biochemical indicators; pharmacodynamics

Abstract

V originále

The aim of this study is to evaluate the possibility of achieving more effective and prolonged sedation in pigs by the oral administration of increased doses of azaperone and to evaluate its safety. This was performed through a prospective randomised and double blinded study. A total of 32 weaned piglets were divided into 4 groups (8 in each group). Group A was given 1 ml of saline orally and served as the control group. Group B received azaperone orally at a dose of 4 mg/kg b.w. Group C received azaperone orally at a dose of 8 mg/kg b.w. Group D was given azaperone orally at a dose of 12 mg/kg b.w. The response to the defined stimulus, movement level, degree of salivation, body temperature, respiratory frequency, blood plasma azaperone concentration and biochemical variables were included in the trial. We found that by increasing the dose of the orally administered azaperone, the onset of the sedation is faster, the end of the sedation starts later and the sedation time is longer. However, the use of higher doses of oral azaperone is not suitable for piglets because the doses negatively affect the respiratory rate, body temperature, some biochemical parameters and cause the immobility of the piglets.

Citovat

SVOBODA, Martin, Jana BLAHOVA, Martin HOSTOVSKY, Jiří JARKOVSKÝ, Jakub NETOLICKY, Patrik PREDNY, Ivana SIMKOVA, Jonas VANHARA and Jan VASEK. Efficacy and safety of higher oral doses of azaperone to achieve sedation in pigs. Veterinarni Medicina. Praha: Czech Academy of Agricultural Sciences, 2022, vol. 67, No 11, p. 553-561. ISSN 0375-8427. Available from: https://dx.doi.org/10.17221/56/2022-VETMED.

@article{2251339,
   author = {Svoboda, Martin and Blahova, Jana and Hostovsky, Martin and Jarkovský, Jiří and Netolicky, Jakub and Predny, Patrik and Simkova, Ivana and Vanhara, Jonas and Vasek, Jan},
   article_location = {Praha},
   article_number = {11},
   doi = {http://dx.doi.org/10.17221/56/2022-VETMED},
   keywords = {behaviour; biochemical indicators; pharmacodynamics},
   language = {eng},
   issn = {0375-8427},
   journal = {Veterinarni Medicina},
   title = {Efficacy and safety of higher oral doses of azaperone to achieve sedation in pigs},
   url = {http://vetmed.agriculturejournals.cz/artkey/vet-202211-0001_efficacy-and-safety-of-higher-oral-doses-of-azaperone-to-achieve-sedation-in-pigs.php},
   volume = {67},
   year = {2022}
}

TY  - JOUR
ID  - 2251339
AU  - Svoboda, Martin - Blahova, Jana - Hostovsky, Martin - Jarkovský, Jiří - Netolicky, Jakub - Predny, Patrik - Simkova, Ivana - Vanhara, Jonas - Vasek, Jan
PY  - 2022
TI  - Efficacy and safety of higher oral doses of azaperone to achieve sedation in pigs
JF  - Veterinarni Medicina
VL  - 67
IS  - 11
SP  - 553-561
EP  - 553-561
PB  - Czech Academy of Agricultural Sciences
SN  - 03758427
KW  - behaviour
KW  - biochemical indicators
KW  - pharmacodynamics
UR  - http://vetmed.agriculturejournals.cz/artkey/vet-202211-0001_efficacy-and-safety-of-higher-oral-doses-of-azaperone-to-achieve-sedation-in-pigs.php
N2  - The aim of this study is to evaluate the possibility of achieving more effective and prolonged sedation in pigs by the oral administration of increased doses of azaperone and to evaluate its safety. This was performed through a prospective randomised and double blinded study. A total of 32 weaned piglets were divided into 4 groups (8 in each group). Group A was given 1 ml of saline orally and served as the control group. Group B received azaperone orally at a dose of 4 mg/kg b.w. Group C received azaperone orally at a dose of 8 mg/kg b.w. Group D was given azaperone orally at a dose of 12 mg/kg b.w. The response to the defined stimulus, movement level, degree of salivation, body temperature, respiratory frequency, blood plasma azaperone concentration and biochemical variables were included in the trial. We found that by increasing the dose of the orally administered azaperone, the onset of the sedation is faster, the end of the sedation starts later and the sedation time is longer. However, the use of higher doses of oral azaperone is not suitable for piglets because the doses negatively affect the respiratory rate, body temperature, some biochemical parameters and cause the immobility of the piglets.
ER  -

SVOBODA, Martin, Jana BLAHOVA, Martin HOSTOVSKY, Jiří JARKOVSKÝ, Jakub NETOLICKY, Patrik PREDNY, Ivana SIMKOVA, Jonas VANHARA and Jan VASEK. Efficacy and safety of higher oral doses of azaperone to achieve sedation in pigs. \textit{Veterinarni Medicina}. Praha: Czech Academy of Agricultural Sciences, 2022, vol.~67, No~11, p.~553-561. ISSN~0375-8427. Available from: https://dx.doi.org/10.17221/56/2022-VETMED.

Detailed Information on Publication Record