Allantoin overaccumulation enhances production of metabolites
under excess of metals but is not tightly regulated by nitric
oxide

J 2022

Allantoin overaccumulation enhances production of metabolites under excess of metals but is not tightly regulated by nitric oxide

DRESLER, Slawomir, Jozef KOVACIK, Ireneusz SOWA, Magdalena WOJCIAK, Maciej STRZEMSKI et. al.

Basic information

Original name

Allantoin overaccumulation enhances production of metabolites under excess of metals but is not tightly regulated by nitric oxide

Authors

DRESLER, Slawomir, Jozef KOVACIK (703 Slovakia, guarantor), Ireneusz SOWA, Magdalena WOJCIAK, Maciej STRZEMSKI, Anna RYSIAK, Petr BABULA (203 Czech Republic, belonging to the institution) and Christopher D. TODD

Edition

Journal of Hazardous Materials, Amsterdam, Elsevier Science BV. 2022, 0304-3894

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30105 Physiology

Country of publisher

Netherlands

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 13.600

RIV identification code

RIV/00216224:14110/22:00128415

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.1016/j.jhazmat.2022.129138

UT WoS

000807244200004

Keywords in English

Antioxidants; Flavonoids; Malic acid; Reactive oxygen species; Ureides

Abstract

V originále

The aln-3 mutant overaccumulating allantoin and respective wild type (WT) strain of Arabidopsis thaliana were exposed to cadmium (Cd) or mercury (Hg) with or without nitric oxide (NO) donor (sodium nitroprusside, SNP) to study crosstalk, metabolic and oxidative changes between these nitrogen sources (organic vs. inorganic). The aln-3 accumulated over 10-fold more allantoin than WT with the effect of Cd and Hg differing in leaf and root tissue: aln-3 contained more ascorbic acid and phytochelatins when treated with Cd or Hg and more Cd in both organs. SNP depleted leaf Cd and root Hg accumulation in aln3 but had a positive impact on the amount of metabolites typically in WT plants, indicating potentially negative relation between allantoin and NO. In agreement, aln-3 roots showed lower NO signals in control or metal treatments, but higher ROS signal, and SNP had more pronounced impact in WT roots. Flavonol glycosides were more abundant in aln-3 and were affected more by metals than by SNP. Malate was the most affected Krebs acid with strong reaction to SNP and Hg treatment. Data indicate that allantoin overaccumulation influences the accumulation of specific metabolites but nitric oxide has a greater impact on the metabolite profile in WT.

Citovat

DRESLER, Slawomir, Jozef KOVACIK, Ireneusz SOWA, Magdalena WOJCIAK, Maciej STRZEMSKI, Anna RYSIAK, Petr BABULA and Christopher D. TODD. Allantoin overaccumulation enhances production of metabolites under excess of metals but is not tightly regulated by nitric oxide. Journal of Hazardous Materials. Amsterdam: Elsevier Science BV., 2022, vol. 436, August 2022, p. 1-10. ISSN 0304-3894. Available from: https://dx.doi.org/10.1016/j.jhazmat.2022.129138.

@article{2251344,
   author = {Dresler, Slawomir and Kovacik, Jozef and Sowa, Ireneusz and Wojciak, Magdalena and Strzemski, Maciej and Rysiak, Anna and Babula, Petr and Todd, Christopher D.},
   article_location = {Amsterdam},
   article_number = {August 2022},
   doi = {http://dx.doi.org/10.1016/j.jhazmat.2022.129138},
   keywords = {Antioxidants; Flavonoids; Malic acid; Reactive oxygen species; Ureides},
   language = {eng},
   issn = {0304-3894},
   journal = {Journal of Hazardous Materials},
   title = {Allantoin overaccumulation enhances production of metabolites under excess of metals but is not tightly regulated by nitric oxide},
   url = {https://www.sciencedirect.com/science/article/pii/S0304389422009281?via%3Dihub},
   volume = {436},
   year = {2022}
}

TY  - JOUR
ID  - 2251344
AU  - Dresler, Slawomir - Kovacik, Jozef - Sowa, Ireneusz - Wojciak, Magdalena - Strzemski, Maciej - Rysiak, Anna - Babula, Petr - Todd, Christopher D.
PY  - 2022
TI  - Allantoin overaccumulation enhances production of metabolites under excess of metals but is not tightly regulated by nitric oxide
JF  - Journal of Hazardous Materials
VL  - 436
IS  - August 2022
SP  - 1-10
EP  - 1-10
PB  - Elsevier Science BV.
SN  - 03043894
KW  - Antioxidants
KW  - Flavonoids
KW  - Malic acid
KW  - Reactive oxygen species
KW  - Ureides
UR  - https://www.sciencedirect.com/science/article/pii/S0304389422009281?via%3Dihub
N2  - The aln-3 mutant overaccumulating allantoin and respective wild type (WT) strain of Arabidopsis thaliana were exposed to cadmium (Cd) or mercury (Hg) with or without nitric oxide (NO) donor (sodium nitroprusside, SNP) to study crosstalk, metabolic and oxidative changes between these nitrogen sources (organic vs. inorganic). The aln-3 accumulated over 10-fold more allantoin than WT with the effect of Cd and Hg differing in leaf and root tissue: aln-3 contained more ascorbic acid and phytochelatins when treated with Cd or Hg and more Cd in both organs. SNP depleted leaf Cd and root Hg accumulation in aln3 but had a positive impact on the amount of metabolites typically in WT plants, indicating potentially negative relation between allantoin and NO. In agreement, aln-3 roots showed lower NO signals in control or metal treatments, but higher ROS signal, and SNP had more pronounced impact in WT roots. Flavonol glycosides were more abundant in aln-3 and were affected more by metals than by SNP. Malate was the most affected Krebs acid with strong reaction to SNP and Hg treatment. Data indicate that allantoin overaccumulation influences the accumulation of specific metabolites but nitric oxide has a greater impact on the metabolite profile in WT.
ER  -

DRESLER, Slawomir, Jozef KOVACIK, Ireneusz SOWA, Magdalena WOJCIAK, Maciej STRZEMSKI, Anna RYSIAK, Petr BABULA and Christopher D. TODD. Allantoin overaccumulation enhances production of metabolites under excess of metals but is not tightly regulated by nitric oxide. \textit{Journal of Hazardous Materials}. Amsterdam: Elsevier Science BV., 2022, vol.~436, August 2022, p.~1-10. ISSN~0304-3894. Available from: https://dx.doi.org/10.1016/j.jhazmat.2022.129138.

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