Other formats:
BibTeX
LaTeX
RIS
@article{2251434, author = {BorgmannandStaudt, Anja and Simon, Michael and Sommerhaeuser, Greta and FernandezandGonzalez, MartaandJulia and Friedrich, Lucia Alacan and KlcoandBrosius, Stephanie and Kepák, Tomáš and Kruseova, Jarmila and Michel, Gisela and Panasiuk, Anna and Schmidt, Sandrin and Lotz, Laura and Balcerek, Magdalena}, article_location = {Basel}, article_number = {8}, doi = {http://dx.doi.org/10.3390/curroncol29080453}, keywords = {childhood and adolescence; cancer; survivor; ART; offspring; health outcome}, language = {eng}, issn = {1198-0052}, journal = {Current Oncology}, title = {The Use of Assisted Reproductive Technology by European Childhood Cancer Survivors}, url = {https://www.mdpi.com/1718-7729/29/8/453}, volume = {29}, year = {2022} }
TY - JOUR ID - 2251434 AU - Borgmann-Staudt, Anja - Simon, Michael - Sommerhaeuser, Greta - Fernandez-Gonzalez, Marta-Julia - Friedrich, Lucia Alacan - Klco-Brosius, Stephanie - Kepák, Tomáš - Kruseova, Jarmila - Michel, Gisela - Panasiuk, Anna - Schmidt, Sandrin - Lotz, Laura - Balcerek, Magdalena PY - 2022 TI - The Use of Assisted Reproductive Technology by European Childhood Cancer Survivors JF - Current Oncology VL - 29 IS - 8 SP - 5748-5762 EP - 5748-5762 PB - MDPI SN - 11980052 KW - childhood and adolescence KW - cancer KW - survivor KW - ART KW - offspring KW - health outcome UR - https://www.mdpi.com/1718-7729/29/8/453 N2 - CCS often wish to have biological children yet harbour concerns about fertility impairment, pregnancy risks and the general health risks of prospective offspring. To clarify these concerns, health outcomes in survivor offspring born following ART (n = 74, 4.5%) or after spontaneous conception (n = 1585) were assessed in our European offspring study by descriptive and bivariate analysis. Outcomes were compared to a sibling offspring cohort (n = 387) in a 4:1 matched-pair analysis (n = 1681). (i) Survivors were more likely to employ ART than their siblings (4.5% vs. 3.7%, p = 0.501). Successful pregnancies were achieved after a median of one cycle with, most commonly, intracytoplasmic sperm injection (ICSI) using non-cryopreserved oocytes/sperm. (ii) Multiple-sibling births (p < 0.001, 29.7% vs. 2.5%), low birth weight (p < 0.001; OR = 3.035, 95%-CI = 1.615-5.706), and preterm birth (p < 0.001; OR = 2.499, 95%-CI = 1.401-4.459) occurred significantly more often in survivor offspring following ART utilisation than in spontaneously conceived children. ART did not increase the prevalence of childhood cancer, congenital malformations or heart defects. (iii) These outcomes had similar prevalences in the sibling population. In our explorative study, we could not detect an influence on health outcomes when known confounders, such as multiple births, were taken into account. ER -
BORGMANN-STAUDT, Anja, Michael SIMON, Greta SOMMERHAEUSER, Marta-Julia FERNANDEZ-GONZALEZ, Lucia Alacan FRIEDRICH, Stephanie KLCO-BROSIUS, Tomáš KEPÁK, Jarmila KRUSEOVA, Gisela MICHEL, Anna PANASIUK, Sandrin SCHMIDT, Laura LOTZ and Magdalena BALCEREK. The Use of Assisted Reproductive Technology by European Childhood Cancer Survivors. \textit{Current Oncology}. Basel: MDPI, 2022, vol.~29, No~8, p.~5748-5762. ISSN~1198-0052. Available from: https://dx.doi.org/10.3390/curroncol29080453.
|