The Use of Assisted Reproductive Technology by European
Childhood Cancer Survivors

J 2022

The Use of Assisted Reproductive Technology by European Childhood Cancer Survivors

BORGMANN-STAUDT, Anja, Michael SIMON, Greta SOMMERHAEUSER, Marta-Julia FERNANDEZ-GONZALEZ, Lucia Alacan FRIEDRICH et. al.

Basic information

Original name

The Use of Assisted Reproductive Technology by European Childhood Cancer Survivors

Authors

BORGMANN-STAUDT, Anja (guarantor), Michael SIMON, Greta SOMMERHAEUSER, Marta-Julia FERNANDEZ-GONZALEZ, Lucia Alacan FRIEDRICH, Stephanie KLCO-BROSIUS, Tomáš KEPÁK (203 Czech Republic, belonging to the institution), Jarmila KRUSEOVA, Gisela MICHEL, Anna PANASIUK, Sandrin SCHMIDT, Laura LOTZ and Magdalena BALCEREK

Edition

Current Oncology, Basel, MDPI, 2022, 1198-0052

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30204 Oncology

Country of publisher

Switzerland

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 2.600

RIV identification code

RIV/00216224:14110/22:00128440

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.3390/curroncol29080453

UT WoS

000845993000001

Keywords in English

childhood and adolescence; cancer; survivor; ART; offspring; health outcome

Abstract

V originále

CCS often wish to have biological children yet harbour concerns about fertility impairment, pregnancy risks and the general health risks of prospective offspring. To clarify these concerns, health outcomes in survivor offspring born following ART (n = 74, 4.5%) or after spontaneous conception (n = 1585) were assessed in our European offspring study by descriptive and bivariate analysis. Outcomes were compared to a sibling offspring cohort (n = 387) in a 4:1 matched-pair analysis (n = 1681). (i) Survivors were more likely to employ ART than their siblings (4.5% vs. 3.7%, p = 0.501). Successful pregnancies were achieved after a median of one cycle with, most commonly, intracytoplasmic sperm injection (ICSI) using non-cryopreserved oocytes/sperm. (ii) Multiple-sibling births (p < 0.001, 29.7% vs. 2.5%), low birth weight (p < 0.001; OR = 3.035, 95%-CI = 1.615-5.706), and preterm birth (p < 0.001; OR = 2.499, 95%-CI = 1.401-4.459) occurred significantly more often in survivor offspring following ART utilisation than in spontaneously conceived children. ART did not increase the prevalence of childhood cancer, congenital malformations or heart defects. (iii) These outcomes had similar prevalences in the sibling population. In our explorative study, we could not detect an influence on health outcomes when known confounders, such as multiple births, were taken into account.

Citovat

BORGMANN-STAUDT, Anja, Michael SIMON, Greta SOMMERHAEUSER, Marta-Julia FERNANDEZ-GONZALEZ, Lucia Alacan FRIEDRICH, Stephanie KLCO-BROSIUS, Tomáš KEPÁK, Jarmila KRUSEOVA, Gisela MICHEL, Anna PANASIUK, Sandrin SCHMIDT, Laura LOTZ and Magdalena BALCEREK. The Use of Assisted Reproductive Technology by European Childhood Cancer Survivors. Current Oncology. Basel: MDPI, 2022, vol. 29, No 8, p. 5748-5762. ISSN 1198-0052. Available from: https://dx.doi.org/10.3390/curroncol29080453.

@article{2251434,
   author = {BorgmannandStaudt, Anja and Simon, Michael and Sommerhaeuser, Greta and FernandezandGonzalez, MartaandJulia and Friedrich, Lucia Alacan and KlcoandBrosius, Stephanie and Kepák, Tomáš and Kruseova, Jarmila and Michel, Gisela and Panasiuk, Anna and Schmidt, Sandrin and Lotz, Laura and Balcerek, Magdalena},
   article_location = {Basel},
   article_number = {8},
   doi = {http://dx.doi.org/10.3390/curroncol29080453},
   keywords = {childhood and adolescence; cancer; survivor; ART; offspring; health outcome},
   language = {eng},
   issn = {1198-0052},
   journal = {Current Oncology},
   title = {The Use of Assisted Reproductive Technology by European Childhood Cancer Survivors},
   url = {https://www.mdpi.com/1718-7729/29/8/453},
   volume = {29},
   year = {2022}
}

TY  - JOUR
ID  - 2251434
AU  - Borgmann-Staudt, Anja - Simon, Michael - Sommerhaeuser, Greta - Fernandez-Gonzalez, Marta-Julia - Friedrich, Lucia Alacan - Klco-Brosius, Stephanie - Kepák, Tomáš - Kruseova, Jarmila - Michel, Gisela - Panasiuk, Anna - Schmidt, Sandrin - Lotz, Laura - Balcerek, Magdalena
PY  - 2022
TI  - The Use of Assisted Reproductive Technology by European Childhood Cancer Survivors
JF  - Current Oncology
VL  - 29
IS  - 8
SP  - 5748-5762
EP  - 5748-5762
PB  - MDPI
SN  - 11980052
KW  - childhood and adolescence
KW  - cancer
KW  - survivor
KW  - ART
KW  - offspring
KW  - health outcome
UR  - https://www.mdpi.com/1718-7729/29/8/453
N2  - CCS often wish to have biological children yet harbour concerns about fertility impairment, pregnancy risks and the general health risks of prospective offspring. To clarify these concerns, health outcomes in survivor offspring born following ART (n = 74, 4.5%) or after spontaneous conception (n = 1585) were assessed in our European offspring study by descriptive and bivariate analysis. Outcomes were compared to a sibling offspring cohort (n = 387) in a 4:1 matched-pair analysis (n = 1681). (i) Survivors were more likely to employ ART than their siblings (4.5% vs. 3.7%, p = 0.501). Successful pregnancies were achieved after a median of one cycle with, most commonly, intracytoplasmic sperm injection (ICSI) using non-cryopreserved oocytes/sperm. (ii) Multiple-sibling births (p < 0.001, 29.7% vs. 2.5%), low birth weight (p < 0.001; OR = 3.035, 95%-CI = 1.615-5.706), and preterm birth (p < 0.001; OR = 2.499, 95%-CI = 1.401-4.459) occurred significantly more often in survivor offspring following ART utilisation than in spontaneously conceived children. ART did not increase the prevalence of childhood cancer, congenital malformations or heart defects. (iii) These outcomes had similar prevalences in the sibling population. In our explorative study, we could not detect an influence on health outcomes when known confounders, such as multiple births, were taken into account.
ER  -

BORGMANN-STAUDT, Anja, Michael SIMON, Greta SOMMERHAEUSER, Marta-Julia FERNANDEZ-GONZALEZ, Lucia Alacan FRIEDRICH, Stephanie KLCO-BROSIUS, Tomáš KEPÁK, Jarmila KRUSEOVA, Gisela MICHEL, Anna PANASIUK, Sandrin SCHMIDT, Laura LOTZ and Magdalena BALCEREK. The Use of Assisted Reproductive Technology by European Childhood Cancer Survivors. \textit{Current Oncology}. Basel: MDPI, 2022, vol.~29, No~8, p.~5748-5762. ISSN~1198-0052. Available from: https://dx.doi.org/10.3390/curroncol29080453.

Detailed Information on Publication Record